Genetic mutations linked to the practice of burning coal in homes in China
... Co-authors of the study include Qing Lan, Ph.D., division of cancer epidemiology and genetics, National Cancer Institute; Wei-Min Gaol, Ph.D., department of internal medicine, University of Michigan, Ann Arbor; Kui-Cheng Zheng, Ph.D., department of environmental and occupational health, University of Pittsb...UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
...n, associate professor of internal medicine in the division of digestive and liver diseases and principal investigator on the grant. "Hopefully, our efforts will provide bigger steps toward understanding the metabolic processes that lead to obesity and some of the metabolic syndromes commonly associated with ...Marijuana use could cause tubal pregnancies
...nction in reproduction," said Dey, who directs the division of Reproductive and Developmental Biology at Vanderbilt. The current study began with the observation that mice commonly used in genetic experiments often fail to deliver pups, even though they become pregnant. Upon flushing the oviducts, the researc...NSF awards 22 new projects for plant genome research
...ize centromeres, which play a central role in cell division and ensure that the newly divided cells each receive a set of chromosomes. A growing challenge is how to handle the massive amounts of data coming out of ongoing genomics projects and to make it readily accessible to the broader community of stude...NSF and AIBS sign cooperative agreement for NEON project office
...," said Elizabeth Blood, program director in NSF's division of biological infrastructure, which funded the award. "These systems change over time and cross all levels of biological organization. To better understand these ecosystems and forecast biological change, ecologists need a new tool to study their s...Experimental drug shown to block mutant protein causing blood disease
...to prod blood cells into an uncontrolled frenzy of division and growth. The overproduction of white blood cell... inside cells, regulating processes including cell division and growth. Abnormal kinases have been discovered to be major culprits in many forms of cancer. Beca...Research suggests new avenue for stopping, preventing colon cancer
...s credited Sudhansu K. Dey, Ph.D., who directs the division of Reproductive and Developmental Biology at Vanderbilt, with maintaining the PPARdelta "knockout" mouse colony that made the study possible. Dey, DuBois and their colleagues previously have demonstrated the importance of PPARdelta in implantation of...Protein is key to fatal disorder and normal cell function
... Institute of Neurological Disorders and Stroke, a division of the National Institutes of Health. Understanding the role of cln3 has implications beyond juvenile Batten disease a rare, untreatable disorder -- because the protein is overproduced by cells in a number of cancers. And the lipid transported by cl...Researchers discover why mutant gene causes colon cancer
...he APC gene did that it regulated cell growth and division but now we know we've been missing a big piece of the picture," reports David Jones, Ph.D., principal investigator of the study and leader of HCI's Colon Cancer Scientific Program. "What we didn't know was that it converts vitamin A into retinoic ac......al BMPs play a role in enhancing the rates of cell division and growth and regulating major developmental events including bone differentiation. Deregulation of BMP pathway activity has also been linked to some tumor growth. To test whether or not BMP4 is indeed a growth mediator, they used techniques from ge...Skin stem cells give hairless mice hair
...erest to clinicians was whether they could undergo division in a lab dish and still have the capability to perform either epidermal repair or hair-follicle generation." To answer those questions, Fuchs and her colleagues first isolated stem cells from the bulge by fusing antibodies to characteristic cell sur...Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
...ncer cells to SUL. Within hours, SUL blocked cell division and disrupted microtubules, which are long, slende... of cancer, such that SUL can suppress the orderly division process in human breast cancer cells. "The findings may be helpful in the development of new breast ...Protein involved in childhood disorder linked to cancer
...on cycle "checkpoint" controls that delay the cell division cycle so that these repair systems have time to work. "Regulation of these protective processes is coordinated through the action of signaling systems that detect DNA damage, interpret and amplify the signal, and call in appropriate repair and chec...Anticancer drug zebularine specifically targets tumor cells
.... In a study of zebularine's effect on the rate of division of cancer cells, Jones and colleagues showed that zebularine slows growth by as much as 68 percent in cancer cells, but only by 21 percent or less in normal cells. These findings were reported in the August 2004 issue of Cancer Cell . Only recently ...New compound could give some types of cancer the one-two punch
...n three days, Li said. "This compound stopped cell division in its tracks," he said. OSU 111 induces apoptosis cell suicide in cancer cells because it keeps key structures called microtubules from working during cell division. Microtubules distribute chromosomes to new cells. OSU 111 also prevents tumor cel...Study suggests cell-cycle triggers might be cancer drug targets
...ving three key proteins believed essential to cell division and growth had little impact on normal tissue deve... environment and, when appropriate, switch on cell division and growth. But when the system is faulty, the cyclins over-respond to the growth signals and can ca...Heartless worms hold clues to cardiac arrhythmias, sudden death
...instructor and Dan M. Roden, M.D., director of the division of Clinical Pharmacology, both at Vanderbilt, to look for evidence that KCR1 impacts acquired long QT syndrome. Using a database of patients who developed acquired long QT syndrome after drug treatment, Yang was able to detect a variant in the KCR1 g...Possible new cure for psoriasis
.... The reason is the greatly increased rate of cell division of the keratinocytes. They form a layer which sepa...effects One of the substances which stimulate the division of the keratinocytes is the proteinsAPPa. It is produced during the decomposition of a larger protei...Emory researchers map structure of anti-cancer molecule
... Taxol already in use. Both drugs work to halt the division of cancer cells by binding to the same site on a protein called tubulin that is involved in cell division. Tubulin is the major component of microtubules, the hollow cylinders that serve as a skeletal system for cells and a scaffold for chromosomes i...Rutgers-Newark biologist links presence of protein to spread of cancerous cells
...nnecting the presence of Rho proteins to this cell division and movement phenomenon, researchers may have begu...searchers' findings identified a link between cell division and a cell's ability to remain associated with its parent tissue. According to Dr. Bonder, researche...