CF Foundation seizes proteomics for drug discovery
BETHESDA, Maryland, May 6, 2002The door to discovering novel cystic fibrosis (CF) drugs just swung wide open as the Cystic Fibrosis Foundation announced its more than $5 million new investment in proteomics research. Cystic Fibrosis Foundation Therapeutics, Inc. (CFFTI), the drug discover...Natural cholesterol-lowerer shows the way
...olesterol-lowering success and possibly opened the door to production of more potent medicines. Dr. David D. Moore, professor of molecular and cell biology, and fourth-year Ph.D. student Nancy L. Urizar discovered that an extract of the resin of the guggul tree - approved as a cholesterol-fighter in India...Peripheral 'Swatch' watches are a powerful force in bodys circadian rhythms
...he bow," said Weitz. "But it potentially opens the door to a kind of complexity that we now have to think about."...Scientists unravel complicated genetic disease in one fell swoop
...cs of an inherited intestinal disease, opening the door to revealing complete genetic pictures of other complex diseases. Their results provide stirring reminders that it's important to consider all parts of a gene, not just those carry instructions for a protein, when looking for contributors to disease....Common microbes survive pressures equal to those found at 50 kilometers inside the Earths crust
...niques developed by Sharma and Scott will open the door for the real time examination of pressure and temperature effects on microbial communities. According to Scott, One of the fundamental questions that needs to be asked now is whether the response exhibited by the bacteria is due to adaptation or sele...Long-distance command sends human growth hormone into action
...ctivation is the equivalent of unlocking the front door of a house from seven buildings away."What we found is surprising because most genes are controlled by a promoter element adjacent to the gene, or within the gene's proximity. But in the case of this human growth hormone, the controlling mechanism i...New mouse model enables studies of heart, brain and spinal cord
...abnormal development of these systems, opening the door to a better understanding of everything from heart defects in children to some cancers to spina bifida. "Now we can say, ‛OK, if this gene is expressed everywhere and is in all these different tissues, can we generate a mouse that will now let...High tech movies reveal information transfer within cells
..., and the two vacuoles become one. This removable door remains intact even as the contents of the two vacuoles mix. "The more we understand how such fusion events occur, the more we have the ability to modulate them. Proteins are conserved from yeast to humans, so the membrane fusion process is very si......b of Reaper, Hid and Grim. Like keys unlocking the door to a dangerous beast restrained behind it, they activate other proteins called caspases to chop up all sorts of proteins, and death ensues." Although scientists understood the mechanics of this cell suicide process, they did not know how it was suppr...Stem cell study provides new clues to origin of Down syndrome
...enes are involved is critical because it opens the door to developing gene and drug therapies that could prevent the onset or development of the syndrome. "I think it is early in the game, but now we can work with a new model for Down syndrome which uses human cells rather than mouse cells," said Svendsen...LabNotes -- research highlights from Pacific Northwest National Laboratory
...and optical sensors track the position of a safe's door and locking mechanism. This information is relayed to an optical sensor mounted at the room's exit point, which sounds an alarm if a worker leaves without fully securing the safe. Secure Safe is being tested at several Department of Energy sites to e...Adding vitamin C to certain drugs may help treat Alzheimers, other brain disorders
...b edition of the journal on Dec. 21. Weve opened a door for a promising new way to improve delivery of drugs into the brain using a natural nutrient, ascorbic acid [vitamin C], says Stefano Manfredini, lead investigator in the study and a professor of pharmaceutical chemistry at the University of Ferrara ...US researchers successfully clone first knockout miniature swine
... the gene that triggers this response, opening the door for further advances. The aggressive (hyperacute) rejection response seen in previous research occurs when human antibodies attach to sugar molecules on the surface of the transplanted pig organs cells. Once they attach, the antibodies kill the cells...A little larceny comes naturally to Northwestern crows
...ble system to study, and we've been able to open a door on crow behavior because we can see what they are doing all the time, what they are feeding on and how they are using their cognitive behavior in the wild. We also can band birds and watch them year after year." The Has are continuing their researc......r study, the receptor, dubbed GCNF, could open the door to new ways of creating embryonic stem cells witho...cells, nerve cells or heart cells. This opens the door to replacing damaged adult cells that are not able to regenerate and may ultimately allow scientists...Molecular basis of mental retardation uncovered
...ecific mRNAsinvolved in the disease has opened the door to new drug targets; it one daymay be possible to manipulate the individual mRNAs, or proteins,responsible for the various symptoms of fragile X as a means to treat thedisease....Gene silencing produces disease resistance in plants
... We're allowing the bacteria in, then slamming the door on them." Analytic tests indicated that there is greater than a 90 percent reduction in gall formation among the genetically engineered tomato and Arabidopsis plants. Other than the lack of galls, however, the genetically engineered plants did not lo...Researchers find gene for rare disorder that paralyzes children's legs
...f their ability to walk - a finding that opens the door to better diagnosis and treatment of the disorder, and to insights into other spinal cord problems. Led by researchers from the University of Michigan Health System who have focused for years on both the childhood and adult forms of the mysterious gr......lusive. The baboons' ability to abstract opens the door to other species' cognitive potential. Fagot et al. state that additional research of non-human animals is necessary before theorists attempt to limit the capability for abstraction only to certain species. They state, "Analogical thinking and its ......e bacterium E. coli is a breakthrough, opening the door for scientists to design a new class of drugs that patients would take in conjunction with antibiotic or chemotherapeutic agents to keep those drugs in the cells and increase their efficacy." MsbA transports lipid A, a component of bacterial cell wa...