Tag: "dose" at biology news

Old drug shows promise for helping treat advanced lung cancer

...and his colleagues wanted to figure out the proper dose of suramin to give to patients...that they could tailor suramin dose levels to individual patients based on the patient's weight and gender. Very low...

Highly specific biological agents attack mechanisms of treatment resistance

... began to regrow four to six weeks after the final dose of Herceptin-DM1, but regressed again when retreat...ival signals to cells. The effect was dependent on dose and schedule. 17-AAG appears to act on pathways in cancer not addressed by approved agents current...

Alternative to hormone replacement therapy shows promising results

...sed by 9.5 percent in the group receiving the high dose of tibolone, 4.5 percent in the PremPro group, and 4.3 percent in the Premarin group. PremPro and Premarin both reduced coronary atherosclerosis by 62 percent, while tiboline had no effect. The Premarin and PremPro groups both had increased cell gr...

Ritalin may cause long-lasting changes in brain-cell function, UB researchers find

...o be short-acting," said Baizer. "When the active dose has worked its way through the system, they consid... group sweetened milk containing a relatively high dose of methylphenidate (20 mg/kg). Considering the differences in metabolism between rats and humans, t...

Biomedicines presents promising results from phase II trials of omega interferon for the treatment of hepatitis C

... As a result, we were able to continue raising the dose level, producing progressive anti-hepatitis C effe...lerability and antiviral activity of six different dose levels of omega interferon in previously untreated patients with chronic hepatitis C. In this open-...

Study shows that aspirin and warfarin are equally effective for stroke prevention

...ical activity. The investigators used an aspirin dose of 325 mg/day and a warfarin dose specifically tailored to each individual patient, and a double-blind plan in which neither the treat...

Science: nanoscale 'Trojan Horse' attacks cancer cells from within

...t of radioactive decay. A single, nontoxic, larger dose injected into mice with prostate and lymphoma tumors caused tumors to shrink and prolonged the mice's survival by several months in some cases. Although it's too early to know what doses might be optimal in treating human cancers, "the doses will pro...

Oral administration of estrogen replacement therapy suppresses the biological actions of growth hormones in GH-deficient women

...ring the second month of each estrogen phase, at a dose of 0.5 IU/day (0.17 mg/day) for the first week, on...sponse study except that patients received a daily dose of growth hormone from weeks four to six during each estrogen phase. On the basis of the IGF-I data ...

Testosterone dose-repsonse relationships in healthy young men

...ipids, and bone metabolism. However, testosterone dose dependency of various hormonal dependent functions... is whether testosterone effects on the muscle are dose dependent, or the nature of the testosterone dose-response relationships. Animal studies suggest th...

Low doses of radiation in nature may pose more risk

...blic health Dr. Tom K. Hei, the study found that a dose that strikes as few as one in 10 cells has nearly the same mutagenic (mutation-causing) effect as a dose that strikes every cell. The added damage occurs, the researchers say, because of what is called the...

Durable responses reported with Bexxar

...reby mediating an immune response and delivering a dose of Iodine-131 radiation to tumor cells. Bexxar is the only investigational NHL therapy that is precisely dosed based on individual drug clearance rates, resulting from such factors as tumor size and metabolism. Patient-specific dosing allows for a ...

Iron supplements help African children learn to walk and talk

... priority for future research. "Although the best dose and duration remains to be clarified, long-term treatment with oral iron may be an important component in the optimal treatment and follow-up of severely anemic children, " said Stoltzfus....

Scientists milk animals for malaria vaccine

...t protected four out of five animals from a lethal dose of the malaria parasite. If the process can be scaled up to larger animals such as goats -- and early experiments indicate it can -- livestock might prove to be inexpensive, high-yield malaria vaccine factories. A vaccine must not only be effective,...

Right better than left in asthma medication for children

...or racemic albuterol three times a day. The lowest dose of levalbuterol (0.31 milligrams, half the recomme...) improved lung function more than the recommended dose of racemic albuterol (2.5 milligrams), which is eight times as large and contains four times as much...

Scientists find alcohol, drugs boost endorphins in key forebrain region

...cotine, but we dont know why. It could be that the dose of nicotine we used was too low or that nicotine does not cause this same effect and instead acts in some other way." Additional research will show whether nicotine increases beta endorphin in the nucleus accumbens or whether it acts on different s...

New research may lead to more effective treatment of asthmatic attacks

...disperse aerosols could open the way to reduce the dose emitted from metered or dry powder inhalers by 80 percent without losing any clinical effect. The means to produce monodisperse or narrow size-ranged steroid aerosols are limited. Present systems, like the spinning-top generator, are cumbersome in th...

LabNotes -- research highlights from Pacific Northwest National Laboratory

...and refine a chemical exposure model to assess low dose exposures, and establish a non-invasive (i.e., saliva) sampling process ideal for use with children. Researchers expect to be able to modify the model in order to assess aggregate and cumulative exposures....

Gene for neat repair of DNA discovered

... Mice with a inactivated Snm1 gene died at a lower dose of mitomycin than mice with an intact Snm1 gene. This was probably because the mice with a inactivated Snm1 could not adequately repair the cross-links. Future research in patients who strongly react to chemotherapy must demonstrate whether this also...

Growth factor receptor signaling critical to intestinal tumor development, studies show

...rastic reduction in tumor growth, depending on the dose they gave the mice, Roberts said. That showed the approach definitely holds promise for using these drugs to treat human cancers. How well our results in mice wind up correlating with human treatment remains to be seen, but at this point were excited...

Scientist: motion sickness drug scopolamine should be tested as new nerve agent treatment

... kilogram of body weight -- a significantly higher dose that would kill all untreated mice six times over, atropine did not boost survival at all. By contrast, 71 percent of mice given scopolamine and 85 percent of mice given scopolamine plus methscopolamine survived. At relatively low but lethal doses o...

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