Temple virologist receives NIH grant to continue investigation of HIV dementia complex
...retroviral therapy. This figure might increase if drug therapy begins to fail in patients who are on ther...fection. "When you put an HIV patient on drugs or drug therapy, the virus goes way down to often undetectable levels," notes Rappaport. "But when you take...RNAi delivery system crosses blood-brain barrier to target brain cancer
... do not receive the treatment. "This is the first drug delivery system that demonstrates that by using RNA interference technology, you can prolong life threatened by cancer," said Dr. Pardridge, Professor of Medicine at UCLA. "By solving the delivery problem, powerful molecular tools and therapies such ...Tufts researchers identify a novel target for cancer therapy
...t metastases due to the lack of reliable validated drug targets. Hsp90 recently has gained significant attention as an important target for cancer therapeutics and hsp90 inhibitors are currently in Phase I and II clinical trials. Since hsp90 is also a key protein for normal cell function, there is some c...Clemson researcher receives Komen grant
...ist has synergistic effects with the breast cancer drug Herceptin, which has only 30 percent response rate. Chen will use the Komen Foundation funding to further establish the molecular bases of the combination of PRL antagonist and Herceptin . "We hope that our research results will soon be translated in...Pharmacogenomics could replace 'trial-and-error' with science from the human genome
...ealth care by decreasing the occurrence of adverse drug effects and increasing the probability of successf... to identify the network of genes that govern most drug responses. Second, systems must be developed to assist physicians and pharmacists in interpreting ge......aboratory of then-fellow Peter Jones. Although the drug had initially been envisioned as a chemotherapy ag... than its role in MDS. "This is the first approved drug in a new kind of therapy-epigenetic therapy," Jones notes. "That gives it tremendous potential impor...'Dissecting sleep' by studying the strange phenomenon of cataplexy
...no effect on the histamine neurons. In contrast, a drug that affected the norepinephrine neurons aggravated cataplexy in the animals. The researchers also conducted experiments that indicated how the histamine neurons are activated during cataplexy -- by the reduction in a key neurotransmitter chemical, g...Molecular image of genotoxin reveals how bacteria damage human DNA
... us some ideas for achieving the same thing with a drug molecule," said Stebbins. Armed with an atomic mod...ested to determine how well they interact with the drug target. By screening compounds by computer before physically testing them, drug makers save time and...Wilex & Fox Chase Cancer Center begin trial w/ novel compound targeting tumor invasion & metastasis
...clinical trial to pursue the possible benefit this drug may have in the treatment of breast cancer," said Lori J. Goldstein, M.D., principal investigator of this study and director of Fox Chase's Breast Evaluation Center and leader of the Breast Cancer Research Program at Fox Chase. "The DOD-Wilex-Fox Cha...Institute for OneWorld Health CEO to speak at BIO on leveraging opportunities for global health
...rofits and other public sector groups might enable drug companies to maximize their assets and underutilized intellectual property without compromising their profitability goals. At the same time, such collaborations could demonstrate greater corporate social responsibility and result in affordable new d...Researchers identify gene linked to sperm-producing stem cells in mammals
...tand all the players then maybe we could develop a drug that could block the decision to become sperm a contraceptive that would be reversible." However, Braun stressed that such products are many, many years away and will require considerable research. Researchers also hope to someday be able to reverse...Combination therapy dramatically improves function after spinal cord injury in rats
...esearchers also gave the rats a form of cAMP and a drug called rolipram, which prevents cAMP from being broken down. Treatment with the triple-combination therapy preserved and even elevated cAMP levels in nerve cells after injury. It also preserved many of the myelinated nerve fibers in treated animal...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
...gs and understanding cellular pathways that affect drug response and resistance. The new report concerns ...implicated in acquired resistance of tumors to the drug estramustine, which is used to treat prostate cancer patients," explained Tew, senior author of the ...Stem cells more vulnerable to toxic chemotherapy when protective molecule is disabled
...t normal oxygen levels and given the anti-leukemic drug mitoxantrone, 40 percent survived, apparently because they used BCRP to rid themselves of that drug. However, if HSCs from mice lacking the BCRP gene were exposed to mitoxantrone under the same conditions, none of the cells survived....OneWorld Health completes enrollment, treatment in Phase III India trial
...e form of paromomycin as a 21-day cure for VL. The drug is an off-patent antibiotic which was previously approved by the U.S. FDA and is still marketed in the U.S. as an oral formulation to treat intestinal parasites. Last June, OneWorld Health initiated the Phase III clinical trial in Bihar, India, in c...Drug combo effective in advanced breast cancer
...." Jonsson Cancer Center researchers first tested drug combinations in the laboratory with the goal of translating their results into patients with HER2/neu amplification, a genetic alternation found in 20 to 25 percent of patients that leads to an aggressive form of breast cancer. Lead by researchers Dr...NPS Pharma and VIMAC Ventures locate at MaRS, a major new research and enterprise center in Toronto
...oscience cluster, MaRS is the perfect site for our drug research and development work in Canada," says Dr.... central nervous system disorders. The company has drug candidates in various stages of clinical development backed by a strong discovery research effort. A...Stuart Lipton honored with Jung Prize for Medicine
...otype treatment based on Dr. Lipton's concept is a drug for Alzheimer's Disease. Dr. Lipton was the first to discover a unique mechanism of action for the drug Memantine, allowing it to work only on pathological conditions and not affect "normal" behavior. Th...New screening method turns up potential compound for treating anthrax
... bacterium. The Chicago research aims to develop a drug that could treat anthrax after antibiotics become ...apid screening is an important component in making drug development more economical. It can cost a pharmaceutical company $250 million to develop a drug. Re...New guidelines show significant benefits of FUZEON for wide range of pre-treated HIV/AIDS patients
...ent for the increasing number of patients with HIV drug resistance. By providing clear advice on timing of... guidelines clarify the place of this breakthrough drug in current HIV treatment regimens and will enable more pre-treated patients to benefit," stated Dr M...