Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
...e enzyme than the sulfa-drug binding site. "If the drug binds to this part of DHPS, the enzyme would lose the ability to bind to DHPP and help the cell make folate," White said, "and if the enzyme mutated enough to avoid the antibiotic, the change in shape of this critical part of DHPS would destroy its a...16th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
...al of the first second generation antisense cancer drug - phase II getting under way * Dr Grant McArthur: Award winning researcher reveals potential new role for Glivec in a soft tissue cancer Chairman: Professor Jaap Verweij (EORTC chairman of conference scientific committee) together with scientific co...A novel, safer strategy for regulating gene expression
...'tailor' gene regulation systems to respond to any drug or chemical," says Dr. Richard Mulligan, director ...vating protein that makes the promoter work, and a drug that, in turn, enables the activating protein. Together, these elements turn the gene on and off. H...Study explores gene transfer to modify underlying course of Alzheimer's disease
...ts delivery to brain cells. The active part of the drug is the NGF gene, the human DNA strand that codes f... Neurosurgery is required to precisely inject the drug into the nucleus basalis of Meynert on both sides of the brain. Dr. Roy Bakay, a Rush neurosurgeon a...Experimental drug shown to block mutant protein causing blood disease
...ith a rare blood disorder by using an experimental drug that blocks signals promoting runaway growth of bl...w her symptoms improve. PKC412, like the spotlight drug Gleevec, is a highly specific "targeted" drug that disables a switch in cancer cells that has become...Yale digital diagnostic technology is basis of new company, HistoRx Inc.
...ce the risk of clinical trial failure and move new drug candidates through the development process more quickly. ...Research suggests new avenue for stopping, preventing colon cancer
...ectal tumor growth," the researchers concluded. A drug that blocks PPARdelta has been developed in France... and eat a high-fat diet without gaining weight. A drug that turns on PPARdelta is being tested in patients with fat metabolism disorders. However, when th...Chemical genetics identifies SARS inhibitors
...ed efficiently. With the goal of finding effective drug leads with which to combat SARS, researchers from the University of Hong Kong conducted a chemical genetic screen to isolate compounds with anti-SARS-CoV activity. The group screened an initial library of 50,240 compounds and found that 104 were pote...New way to protect brain from stroke damage
... they showed. Two agents known to block ASICs--the drug amiloride and the tarantula venom called PcTX--protected the nerve cells against acid-induced injury. Cells lacking ASIC1a, the calcium-permeable type of the acid-sensing channels, were resistant to acid injury. To test that activation of ASIC1a is i...Washington University in St. Louis leads group studying aging process
...tective pathways already are drawing interest from drug companies as targets for new therapies."...A liking for sweets, combined with novelty seeking, may predict alcoholism
...ed to a residential treatment program for alcohol, drug dependence, and/or interpersonal problems related to substance-abusing family members. All participants were given a routine medical examination. In addition, on the 24th day after admission, participants were given the Tridimensional Personality Q...First glimpse of DNA binding to viral enzyme
...been solved by other techniques and can be used in drug design." At the National Synchrotron Light Source -- a facility that produces extremely bright beams of x-ray, infrared, and ultraviolet light at Brookhaven Lab -- Einstein's Sayan Gupta, the study's lead author, bombarded different solutions ...Researchers identify distinctive signature for metastatic prostate cancer
...s. Blocking Hedgehog signaling with cyclopamine, a drug discovered by Beachy's group that targets another protein in the pathway, Smoothened, inhibited growth of these cell lines. Furthermore, they showed that when the tumor cells were introduced into mice, cyclopamine caused a permanent regression of t...New dye directly reveals activated proteins in living cells
...iving cell. Currently, automated "high throughput" drug assays are conducted on thousands of cells at a time, but in vitro, in laboratory test tubes. Cdc42, a member of the Rho family of proteins, regulates multiple and sometimes opposite functions within the cell: movement, proliferation, cell death and ...Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
...nd thus introduce a novel therapeutic approach and drug prototype for treatment of IBD."...PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
...ns interact with which human host cells will point drug designers toward quick and effective treatments during an outbreak. To conduct the analysis of these microbial proteins, scientists at PNNL will use proteomics instruments and approaches unavailable elsewhere that simultaneously combine the high-reso...The impact of genetic variations on the treatment of early rheumatoid arthritis
...rexate, 10 milligrams twice weekly of the anti-TNF drug etanercept, and 25 milligrams of etanercept twice ...better responses to treatment, regardless of which drug was used. "Results of the current study suggest that, at least for RA patients with early active d...Final Alert: 16th EORTC NCI AACR Symposium
...: First-time public presentations on new cancer drug research and development from experts in Europe, N... study of first second-generation antisense cancer drug used in patients Trial shows which brain cancer patients benefit from temozolomide genetic predic...'Defensive' action by influenza viruses demonstrated by Hebrew university researcher
...pt to nullify the effectiveness of the anti-viral drug symmetrel (generic name). The revelation can have significant consequences in leading drug researchers to develop new and more effective means to block influenza and other viruses in the futu......versity of California, San Francisco, found that a drug called zoledronic acid was able to halt the progre...ssion and growth. The researchers showed that this drug acted by both decreasing matrix metalloprotease-9 gene expression and inhibiting the activity of any...