Disease diagnosis, drug development focus of UH prof's biochip research
... 1, 2004 Leading the way to disease diagnosis and drug development, biochip research at the University of...ations in genetic screening, disease diagnosis and drug development. "The design of biochips depends critically on our understanding of how biological mo...JCI table of contents: 1 September, 2004
...versity of California, San Francisco, found that a drug called zoledronic acid was able to halt the progre...ssion and growth. The researchers showed that this drug acted by both decreasing matrix metalloprotease-9 gene expression and inhibiting the activity of any...Scientists discover proteins involved in spread of HIV-1 infection
...le, the VPS37 proteins are therefore potential new drug targets, though of course many significant hurdles remain to be overcome, such as inhibitor screening and potential problems with cellular toxicity."...Other highlights in the September 1 JNCI
...een used as a treatment for neuroblastoma, but the drug can also make some neuroblastoma cells resistant t...ggest that this pathway may be a target for future drug development. In addition, because fenretinide increased the level of a neuroblastoma cell marker--on...Probing the surface of white blood cells to enhance immune system medicine
...these proteins would provide a specific target for drug therapy. "If there is one key protein involved in this process then there is the potential to basically figure out what chemical you could jam into a site on this protein--sort of like wedging a door open so it doesn't shut," explained Higgs. "And w...MIT team explains yin-yang of ginseng
... formation to the pharmacological behavior of this drug and its structure." MIT's role in the collaboration grew from Sasisekharan's expertise in complex sugars, which turn out to be key to ginseng's activity. "The sites where sugars are attached and how they are attached are unique for each of the molecu...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
...into host CD4 T-cells, are quickly moving down the drug development pipeline. Chief among these therapeuti...vides an exciting window of opportunity for future drug development. The goal is to block the assembly or ensuing action of Vif on APOBEC3G, thereby preserv...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...rsonal care products in the environment, including drug occurrence, monitoring, transport, fate, treatment...many disease states as well as provide targets for drug discovery," adds Beecher. ( ANYL 192 , Wednesday, Aug. 25, 3:50 p.m., Loews, Regency C1, during the ...Study of flu patients reveals virus outsmarting key drug
MADISON - A drug envisioned as a front-line defense for the next fl...dren with influenza and treated with the antiviral drug oseltamivir was conducted by an international team of researchers led by virologist Yoshihiro Kawaok......ersity and co-author of the study. "These emerging drug resistant viruses present a treatment challenge and the existing drug cocktails will need to be tailored accordingly." "Our findings are different than those previously p...Bright idea could doom cancer and viruses, say Purdue scientists
...ubstances they have more control over. If we had a drug we could activate when it reached a certain place in the body - and nowhere else - it would reduce the stress on the rest of a cancer patient's system." Morrison's group experimented with several different chemical complexes that use rhodium, a rare...Tiny molecules have big potential as cancer drugs, Stanford researcher believes
...ward the possibility of a different type of cancer drug small molecules that would home in on the proteins tumors need without poisoning patients. Matthew Bogyo, PhD, assistant professor of pathology, will discuss his studies of some of these molecules at an Aug. 24 talk during the "Genomic Approaches to...Marathoning mice could have Olympian effects on obesity
... his team treated normal mice with an experimental drug called GW501516 that activates PPAR-delta. These m...ained less weight when given a high-fat diet. This drug is now in the earliest stages of being tested on people for its effects on obesity and other disorde...Trojan Horses, xenon imaging and remote controlled genes
...interesting applications, including new agents for drug delivery, templates for forming metal nanoparticles and chemical probes for use in in vivo spectroscopic studies. A Light Switch for Turning Off Genes In order to understand the role of certain genes in embryonic development, the Dmochowski...OneWorld Health compiles comprehensive state of infectious diarrhea treatments, potential solutions
...Health is pursuing safe, effective, and affordable drug candidates for pediatric diarrhea that will reduce stool output and save babies' lives. A new drug may be used in conjunction with oral rehydration therapy (ORT) in the developing world. ORT is the g...No longer just for biology, RNA can now be built into 3-D arrays
...machines into nanodevices for such applications as drug or gene delivery, gears for nano-equipment, and intricate arrays and chips for diagnostic devices, sensors and electronics." Peixuan Guo "This report demonstrates that RNA can be used to form a variety of artificial shapes and that we can assemble t...Anticancer drug zebularine specifically targets tumor cells
LOS ANGELES, August 23, 2004 A novel anticancer drug that inhibits a process known as DNA methylation i...methylation. "This was the first time this type of drug has been able to reactivate silenced genes through oral administration," noted Jones. This new study...Genetically-engineered 'marathon mouse' keeps on running
..., called GW501516, that activates the protein. The drug is being developed by GlaxoSmithKline to treat peo...s and his colleagues found that treatment with the drug produced muscle and metabolic benefits similar to what they saw in the transgenic mice. The researc...Cleaner water, more efficient electricity among UH chemical research
...r potential applications in biomedical devices and drug delivery using carbon nanotubes. P. Shiv Halasyamani, assistant professor of chemistry, will talk about the importance of seeking out mentors at every stage in one's scientific career, as well as discussing the rewarding experience of being a men...New compound could give some types of cancer the one-two punch
...s are working on developing a multi-purpose cancer drug that might one day scale back the number of medica...--------------------------------------------- "One drug with dual activity means that the body only has to deal with a single compound, and that could elimi...