Livermore research in accelerator mass spectrometry highlighted at ACS meeting
...r cells, pharmacokinetics and development of novel drug delivery devices. Henderson will present an overview of AMS applications in biological research and the use of AMS to detect a new type of DNA damage in breast cancer cells. Charles Westbrook of the Chemistry and Materials Science (CMS) Directorate w...Heartless worms hold clues to cardiac arrhythmias, sudden death
...ear why some individuals receiving a HERG-blocking drug develop the syndrome, Petersen said. "It's a serio...oblem," she said. "The FDA now requires that every drug be assayed for HERG block before it is approved." Even medicines that might be beneficial for the va...New understanding of the machinery of flinching
...affected. Conversely, the researchers found that a drug that reduced neuronal activity in the polysensory zone selectively reduced the sustained, directed phase of the flinch. The researchers' analysis indicated that the effects on the polysensory zone were partly due to alteration of the muscle response ...Newly discovered protein may be key to muscular dystrophy
...er. Transporters have proven to be important drug targets, McIntire said. Prozac, for example, modulates a transporter that regulates serotonin concentration. Besides carrying messages from nerve cells to muscle cells, acetylcholine triggers communication between neurons in the brain, and is involve...MIT research that stops pain of needle jabs gets FDA approval
...loping new principles and materials for controlled drug delivery and tissue engineering, is a director and chairman of the scientific advisory board of the company. The small, battery-powered device applies a low-frequency, ultrasonic energy to the skin for 15 seconds. The sound waves open small cavities ...When is a mouse like a test tube?
...mful effects in the body, based on use of the AIDS drug AZT (azidothymidine) and phosphine-gold compounds for treating arthritis. Bertozzi figured that if she could attach an azide to a natural sugar and feed it to cells, she could insinuate the sugar into the sugar polymers (oligosaccharides) that decor...Other highlights in the August 18 JNCI
...lencing could be a potential target for anticancer drug development. Contact: Israel Vlodavsky, Bruce Rappaport Faculty of Medicine (Technion, Haifa), 972-4-829-5410, vlodavsk@cc.huji.ac.il Researchers Study Molecular Mechanisms Involved in Medullary Thyroid Carcinoma In a new study of medullary thyr...Institute for OneWorld Health nominated for the 2004 World Technology Awards
...honored to be recognized so highly for our work in drug development to address global health inequities," stated Victoria Hale, Ph.D., Founder and CEO of OneWorld Health. "We are gratified by the confidence our peers have in our ability to deliver on our goal to provide affordable new medicines for peopl...X marks the spot: Vector insertion is viral specific
...t to target is integrase, the object of a new AIDS drug recently tested in rhesus monkeys. "If there is a 'targeting factor' required for efficient replication, then blocking its function might obstruct viral replication," says Bushman. "The clearest way forward is to inhibit the catalytic activity of the...ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
...he advance could have significant implications for drug development by allowing scientists to monitor the ...y said the new AFM method could be significant for drug discovery. "This development opens up the AFM as a research tool," Lindsay added. "The ability to id...'New and better drugs for tuberculosis' goal of UH professor
...off as a mere molecule may soon become a potential drug to treat tuberculosis. Krause, an associate prof...s a protein from tuberculosis that is a target for drug design," Krause said. "We are trying to make a small molecule that will specifically inhibit this e...Story tips from the Department of Energy's Oak Ridge National Laboratory, August 2004
...has broad implications for protein engineering and drug design. Using biomolecular simulations, Agarwal has identified a network of protein vibrations in the enzyme cyclophilin A., which is involved in many biological reactions. These include protein folding and intracellular protein transport. Cyclophili...Emory researchers map structure of anti-cancer molecule
... The researchers have now examined two drug families the epothilones and taxanes, which include the anti-cancer drug Taxol already in use. Both drugs work to halt the division of cancer cells by binding to the same si......e promise of chronotherapy, which seeks to deliver drug treatments at optimal body times. A new study by H...ical treatment may one day allow doctors to tailor drug administration to a patient's body time, which promises to optimize efficacy and reduce adverse effe...Leukemia stem cells identified by Stanford researchers
...e whose cancers were resistant to the chemotherapy drug Gleevec. Beta-catenin is part of a pathway kicked off by a protein called Wnt (pronounced "wint"), which has only recently been found to play a role in helping stem cells continue dividing. Wnt is normally only active in cells that must continually d...New OHSU lab will speed drug discovery process
...will more quickly move benchtop discoveries toward drug discoveries with the help of a new, service-orient...logy, OHSU School of Medicine, will analyze drugs, drug metabolites and other molecules, such as simple peptides, oligonucleotides, lipids and steroids. It ...Jefferson scientists find gene expression pattern may predict behavior of leukemia
...of miRNAs in cancer and provide targets for future drug development....Evolvability could be a driving force in drug resistance
...of experimental results including the evolution of drug resistance in bacteria, the fact that some immune ...ility of the pathogens themselves," Earl said. "In drug design, it is important to consider this and to look for ways to minimize or counteract this driving......? These are big questions in neuroscience and this drug will help us answer some of them." Conducted with scientists at Albert Einstein College of Medicine in New York and funded by the National Institutes of Health, the research offered up an intriguing secondary finding. In rare cases, mefloquine can ca...Outcome for acute lymphoblastic leukemia linked to gene expression patterns
...three of these genes had been previously linked to drug resistance. These new genes represent potential ta...sed) of genes in cells that were resistant to each drug to the level of expression of genes in cells that were sensitive to the same drug. The main study g...