Babies with DiGeorge syndrome saved by immune supression, thymus transplant
...ashing the rogue T cells with an immunosuppressant drug given for three days immediately before transplant surgery resulted in successful thymus transplants. Five of six infants who underwent the new procedure survived and now live at home; one succumbed to a preexisting respiratory infection. "This reall...Commercialization deal boosts hope for new sickle-cell drug
...CA-17043 is related to clotrimazole, an antifungal drug approved in 1975 and long used to treat vaginal ye...rk, N.C. Icagen, which focuses on ion channels as drug targets, did further chemical work to optimize the drug and sponsored Phase I and Phase II studies. ...Activated signaling pathway may predict lung cancer patients' response to gefitinib
...a specific activated signaling pathway, the cancer drug gefitinib (Iressa) was associated with a better re...chemotherapeutic intervention. Gefitinib, a cancer drug that interferes with the epidermal growth factor receptor (EGFR) pathway, is active in approximately...From science fiction to reality: Nanomedicine brings fresh hope to the medical world
...nd applications of the healthcare sector including drug delivery, drug discovery and development, diagnostics and medical devices. "Nanomedicine holds the promise of site...New technique helps scientists reveal interactions between genes and drugs
...ess of medications. These differences can change a drug that is a lifesaver for some patients into a toxin...y higher numbers of cell deaths in response to low drug doses. The robot also highlighted cell lines with high resistance to the drugs where few or no cells...Clusters of alterations on PIK3CA gene found in brain cancers
...pe and move. Kinases have been the focus of recent drug development strategies, with some tumor-inhibiting compounds such as Gleevec, which is a protein kinase inhibitor already in use clinically to thwart tumor growth. Yan and colleagues pinpointed a cluster of 13 mutations on two particular areas of t...Two-pronged attack targeting EGF receptor hinders cancer cell growth
... proved synergistically more effective than single drug treaent at several levels. "The combination of Er...cess known as apoptosis. And in animal models, the drug combinations limit lung cancer cell growth and tumor development more effectively than any of the dr...Iron can have negative side effects on people with kidney disease
...ment therapies, this study could ultimately impact drug selection by physicians....Firefly compound lights up 'protein dance' in living animals
... regulation of the cell life cycle. An anti-cancer drug is being developed to block the interaction of the... proteins. "We can now monitor the effects of that drug in live animals using the luciferase technique," says Piwnica-Worms. "It's been an exciting developm......ploration of gene function in many basic research, drug discovery, and clinical settings. Until now, however, the identity of the molecular scissors that carry out RNAi-mediated messenger RNA cleavage has not been revealed. Two studies published this week in Science have resolved this mystery by establi...U of T research answers key question in biochemistry
...ely predict protein structure has implications for drug design, as well as for improving commercial products. Understanding the pathway a protein follows will also help scientists understand errors in folding, a problem linked to diseases such as cystic fibrosis and Alzheimer's. ...Misfiring proteins tied to inflammation and sick feeling of type 2 diabetics
...d sickness behavior; Determine if a potential new drug combination could improve neuroimmune function in ...s that combining vanadyl sulfate with rapamycin, a drug used to lower the risk of rejection of transplanted kidneys, might reduce diabetes-associated inflam...NIH renews funding for continued Rb2 tumor suppressing gene research at Temple
...cer in the liver and ovaries, the effectiveness of drug therapies against breast cancer, and as a potential prognosticator of prostate cancer. "The grant from NIH is recognition of our hard and creative work on Rb2/p130 over the past 12 years," says Giordano. "With this funding, we will be able to atta...Colleagues to recognize research leadership in cancer detection, prevention and treatment
...istry, biochemistry or tumor biology as related to drug discovery:AACRBruce F. Cain Memorial Award, established in 1982 by Warner Lambert Company (now Pfizer) to honor Dr. Bruce F. Cain, whose scientific interests involved the design, synthesis and biological evaluation of potential anti-tumor drugs. The...Yale scientists visualize details of how hepatitis C unwinds RNA
... are particularly important because NS3 is a major drug target against HCV and understanding the helicase function will aid in the development of HCV inhibitors. Pyle's results contradict the idea that helicases move smoothly with the continuous action of a snow plow. Instead, NS3 moves with a discontinuo...Good bacteria trigger proteins to protect the gut
...ling. In initial experiments, they gave the mice a drug called DSS, which is toxic to epithelial cells in ...l mice recovered easily from DSS exposure, but the drug severely damaged the intestines of the MyD88-deficient mice. The researchers found essentially the s...New view of leukemia cells identifies best treatment options, Stanford researchers say
... to the next most effective treatment or perhaps a drug still in development. This process is time-consumi...ew technique for getting AML patients on the right drug the first time in the July 23 issue of Cell. Although all people with AML have a cancer of the same...Scientists discover new intricacies in how ulcer bugs stick to stomach
...at infections. In addition, resistance to standard drug therapies is a major problem in these countries. H. pylori can survive in human stomachs for decades, employing many tricks to do so. To avoid being flushed out by digestive processes, the bacteria stick to cells lining the stomach wall, from whi...Researchers uncover surprising degree of large-scale variation in the human genome
...development, and others implicated in leukemia and drug resistant forms of breast cancer. In addition, some CNPs identified genes with known influence on 'normal' human phenotypes including oneneuropeptide-Y4 receptorthat is directly involved in the regulation of food intake and body weight. Accordin......one organochlorine, vancomycin, is the life-saving drug for treating penicillin-resistant bacterial infections in hospital patients. "The first edition in 1996 had about 2,400 compounds," he says. "The new edition will have more than 4,000. As chemists continue to explore terrestrial and marine...