Why some neonates need caffeine
...hanced during caffeine administration, because the drug amplifies the drop in ventilation compared with controls. The same data clearly indicate that the peripheral chemoreceptors' contribution is crucial. Unfortunately, the mechanism of action by which caffeine acts on chemoreceptor activity is unknown....A pathway to blocking autoimmunity
...tem's first responders--Nagy and colleagues used a drug called rosiglitazone to increase PPAR-gamma activi...ting the mechanism in patients. Rosiglitazone, the drug they used to activate PPAR-gamma, is already used in the United States to improve insulin sensitivit...Study yields insights into precancerous condition
... downstream of the mTOR protein. "We knew that the drug rapamycin [commonly used to prevent newly transplanted organs from being rejected] could block mTOR," says Cantley. "These new results suggest that the use of mTOR inhibitors, including rapamycin analogs currently being tested in clinical trials for ...Drug prevents chemotherapy-induced hearing loss, study finds
PORTLAND, Ore. -- A drug used to treat people with Tylenol poisoning preven...r cells. In addition to head and neck cancers, the drug is used to treat cervical carcinoma, lung cancer, neurologic cancers and a wide variety of other mal...Unique partnership between UH, FDA opens path for scientific exchange
...practical experience about the process of having a drug or device approved by the FDA." UH faculty on sa...ientists and facilities, experience the device and drug approval pipeline firsthand, learn how the FDA protects the public health, have an opportunity to pr......on, good quality translational research, efficient drug development and large prospective clinical trials....latform for presentation of the latest findings in drug research and development to around 2,000 international experts in the field. All data at the four-da......h as cancer. However, it is a difficult target for drug intervention because it is a vital component of most cells in the body; curbing its activity could kill all cells, including healthy ones. Verma and his group hope that by pinpointing other molecules that help NF-kB do its job, they may find new ways...'Crack babies' do better when placed with non-family caregivers
...h focused on the potential negative impacts of the drug itself, treating other factors associated with maternal drug use as interfering. However, as researchers accumulated more information, many concluded that focus...Sponge substance works well with yew derivative to thwart cancer cell proliferation
A drug derived from an ocean-growing sponge teams up to e... Cancer Research . Indeed, discodermolide, a novel drug isolated from the marine sponge Discodermia dissoluta, works with paclitaxel to thwart tumor cell gr...New drug shows promise against Gleevec resistance in mice
...s the development and implementation of Gleevec, a drug that virtually halts the progress of chronic myelo... "The identification of this compound as a drug candidate is a direct byproduct of understanding why patients develop resistance to Gleevec," said S...Protective mechanism exploited by tumors may provide new cancer treatment
...mune system. They also found that when they gave a drug to block IDO expression, the immune system rallied...ents. "We have demonstrated that the IDO inhibitor drug is useful in mice," says Dr. Munn. "It's useful in a tumor model that is related to the kinds of pat...New database to help develop AIDS drugs
Researchers who are either developing drug treatments for AIDS or studying the virus that causes the disease have a new resource---an online database of AIDS-related protein structures just unveiled for public use by the National Institute of Standards and Technology (NIST). Developed in c...Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
... by external stimuli such as sensory experience or drug treatment. "Our transgenic mouse is a novel tool t...l diseases and has broad implications for rational drug design in the treatment of schizophrenia as well as many other psychiatric diseases, according to Ba...Acamprosate: potential medication for treating alcoholism
...act," he said, " not enough of this is done during drug development. This is especially true of medications that work on the brain and liver, where alcohol has its major effects. It is important to know whether a medication can alter the metabolism of alcohol, for example, increasing blood alcohol level...Argonne scientists determine structure of staph, anthrax enzyme
...on that will lead to structure-based or "rational" drug design. The problem is that researchers don't know...veral other gram positive bacteria. That means one drug could double up and target a variety of different bacteria. Also significant, the enzyme is found on...Vollum scientists find new form of dopamine transmission
...on of the current, and even levodopa, or L-dopa, a drug converted in the brain to dopamine and which enhanced dopamine stores. L-dopa is used clinically to treat Parkinson's disease symptoms. The study focused on dopamine transmission in the substantia nigra, a part of the midbrain where dopamine cells lo...Findings suggest need for new view of p53 cancer protein's interaction with DNA
...al function, the answer to this question is key to drug development efforts aimed at countering the effect...drugs targeting the activity of p53, because these drug development efforts will require a very detailed understanding of how p53 binds DNA," Halazonetis sa...Vioxx in high doses causes hypertension
...shown to be more effective than lower doses of the drug in relieving chronic pain, and it has been linked ...sk for developing high blood pressure, because the drug could make that condition more difficult to control, Griffin said. However, many other doctors appar...Report outlines steps needed to lessen smallpox threat
... targets for conventional current state-of-the-art drug development. "Level two of the scientific issues w...tions." One of the long-term goals of an antiviral drug development program should be to attract academic researchers to the study of poxviruses. "Poxvirolo...New lower-cost assay system equivalent to flow cytometry for accurate CD4+/CD8+ cell counts
...ts have broad applications in scientific research, drug discovery, cell counting, and optimization of commercial bio-production. The introduction of Guava's technology platform for clinical diagnostic use begins with the CD4/CD8 assays for HIV/AIDS monitoring in developing countries. There is also enormou...