Lack of immune system protein prevents lupus-like condition in mice
... may be an ideal target for the development of new drug treatments, scientists said. "What's perhaps most exciting is that normal immune system functions were still largely intact in the experimental mice that lacked SAP," says Stanford Peng, M.D., Ph.D., assistant professor of medicine in rheumatology an...OHSU scientists find gene influencing drug withdrawal
PORTLAND, Ore. -- One of the genes that influences drug physical dependence and associated withdrawal has ...nner throughout the addictive process to influence drug use or abuse. We think that physical dependence on sedative-hypnotic drugs and associated withdrawal...U of T microbiologists achieve results with pattern recognition software
...e researchers used a technique in which adding the drug doxycycline to the yeast cells disables an individual gene. This technique is a reliable alternative to the more common method of causing mutations by radiation, because the mutations are engineered rather than random. The 700 yeast strains develope...University of Chicago scientists pinpoint cellular cause of SIDS
...twork of cells. Researchers found that riluzole, a drug that blocks the cell's sodium channel, could silen... silence the sodium-driven pacemakers but also the drug cadmium to silence the calcium-driven pacemakers. The rhythm stopped, confirming that pacemaker neur...Anti-cancer agent built from anti-inflammatory drug
...s have used a recently developed anti-inflammatory drug as a starting point to construct a possible new, t...tion Development (RAID) program. The potential new drug was developed by researchers at The Ohio State University College of Pharmacy and the OSU Comprehens...Other highlights in the July 7 JNCI
...ose of a phase I clinical trial of a new cytotoxic drug is to determine the side effects associated with increasing drug dose, i.e., determine the dose that produces the maximum effect at which the toxicity can still be t...RICE gets $1.1m from DOD to study neurofibromatosis
...ns that regulate NF in humans. Ultimately, we hope drug companies can use these proteins as targets for ne... so, the molecule, known as PKA, might be a useful drug target. Another aspect of the research involves a search for NF-like tumor growth in dozens of strai...UNC research accelerates discovery of novel gene function
...e system may have clinical applications, including drug design, Kafri added."We could easily modify the li...stically accelerate the process of high-throughput drug design and testing, taking gene candidates from cell culture to the animal model." The technique use...Chemoradioimmunotherapy for advanced breast cancer: hope for the future?
...ent consisted of vinorelbine-tartrate (a cytotoxic drug used in the treatment of breast (and other) cancers), the radiotherapy component was provided through the addition of high energy radioisotopes, whilst the immunotherapy aspect was achieved by attaching an antibody specific to HER-2 to those radioiso...Protein controls acid in cells by direct detection of volume changes, study finds
... NHE1 transporter is a protein of much interest to drug developers investigating ways to prevent cell death, which often accompanies heart attacks and strokes. In ischemia, where the blood supply is cut off to cardiac cells or brain cells, cells become very acidic. As the body's normal metabolism gets goi...Gene alteration points to longevity, thinness
... precursor for fat and cholesterol. "If you find a drug which can block the function of this transporter, it might interfere with the use of citrate for fat and cholesterol synthesis which should help people lose weight and reduce their cholesterol," Dr. Ganapathy says. Drs. Fei and Ganapathy also are wor...Bacterial protein recycling factor possible key to new class of antibiotics
...on mitochondrial protein synthesis. "With rational drug design it is even possible to design anti-RRF which would only influence bacterial RRF," says Kaji. His lab is currently identifying the ribosomal site to which RRF is moved from the currently identified position. "It is from this position where RRF...Bacteria spill their guts to aid researchers in quest for new antibiotics
...of MscL, which may have implications for potential drug therapies designed to kill microorganisms. They al...ailable online. "If you're looking for targets for drug therapy and this protein could possibly be one you need to know what the target looks like and how...Chemical Society announces EPA awards for environmentally friendly technology
...y developed a better route to paclitaxel, a cancer drug used to treat ovarian and breast cancer. Paclitaxel was first isolated from the bark of the Pacific yew tree. Harvesting the bark meant sacrificing the tree, which provides habitat for the endangered spotted owl. Bristol-Myers Squibb designed a semi-...New milestones on the path to conquering HIV drug resistance (AIDS)
...re clearly on the track of solutions to combat HIV drug resistance. Leading a multidisciplinary ensemble o... The two life-saving drugs approach the problem of drug resistance in different ways. Arnold and his colleagues work on drugs that target HIV RT. "We try ...Early dexamethasone exposure has long-term neurodevelopment, neuroendocrine effects
...en human infants are traditionally exposed to this drug in the neonatal intensive care unit. This model was recently used to demonstrate an association between dexamethasone exposure in the neonatal rat pup and changes in LHPA function in the adolescent, including increased anxiousness in the light-dark ...RSV can increase the risk of asthma, UT Southwestern researchers find
...er as adults." Earlier studies have shown that the drug Palivizumab resulted in a 55 percent reduction in ... did not. To determine whether the antibody in the drug was effective against RSV, UT Southwestern researchers infected healthy mice with RSV and monitored ...Mice with hyperactive Wnt10b gene eat all they want, but have half the body fat of normal mice
... in decreasing fatty tissue, but finding the right drug to selectively target this pathway without complications will be a considerable challenge," MacDougald says. "The goal of our research is to learn how fat cell development is regulated, but this work may also improve our understanding of obesity and ...Biologists ID defense mechanism of leading fungal pathogen
... that would give us one more useful target for new drug therapies." Candida is common in humans. It's estimated that 70 percent of people have Candida colonies in their intestines, mouths or on their skin. In most cases, the organism is commensal, meaning it does not harm people, even though it depends up...... the potential for developing a Twist inhibitor, a drug that wouldn't kill a tumor but rather stop its metastatic capabilities. "Something like that would turn cancer into a chronic disease, rather than a deadly one," she suggests. Yang also can see potential to apply these findings diagnostica...