Mutant mice lead to memory insights
... from the mutant mice and to the mice themselves a drug that inhibits de-acetylation -- thereby maintainin...d to normal, and the mutant mice that received the drug showed a reversal of their memory deficits. "Our study therefore suggests that it might be possible...$5 million grant funds partnership, studies of minority-based issues in reproductive health
...y will examine the effects of a combination of two drug therapies and lifestyle intervention in women with polycystic ovary syndrome, a condition that causes irregular periods, inability to get pregnant and excessive facial and body hair. All three of these studies offer participants compensation for the...Protein believed to control formation of memory identified by Scripps & UCSD scientists
...ere able to correct this defect by administering a drug that restored CBP's function. "This is significa... defect in the animals by administering a leukemia drug called histone deacetylase inhibitor Trichostatin A, which put the acetyl group back on the histones...Jefferson researchers develop microchip to track genetic signature of cancer and normal tissue
...of miRNAs in cancer and provide targets for future drug development. They reported their findings June 21, 2004 online in the Proceedings of the National Academy of Sciences. Dr. Croce explains that miRNAs are thought to play important roles in regulating gene expression during development and cell diffe...Targeted therapy for lung cancer patients shows promise in extending lives
...udy." Targeted therapy is based on the idea that a drug will attack its target without damaging other tissue. This combination therapy is better at focusing on abnormal signals that drive cancer cells, while sparing more of the body's healthier cells. By blocking essential pathways within tumor cells, the...Protein stops blood-vessel growth, holds promise as cancer therapy
...est in recent years, with the first antiangiogenic drug being approved earlier this year. Endothelial cells have been the target of most antiangiogenic strategies. Endothelial cells are specialized cells that develop into blood vessels. Fibulin-5, a member of a family of extracellular matrix proteins that...Researchers show 'clot-busting' at stroke site is viable option
...nted in a large national trial of intravenous (IV) drug treatment for stroke. In all cases, time was an is...e patients using the intra-arterial (IA) method of drug delivery over the time period observed, between 1993 and 2002, but only 36 patients received the med...Harmless virus helps slow HIV by boosting immune proteins
...plication, before it even enters T cells. But this drug costs up to $25,000 per year and must be given by injection twice daily. Other drugs that work similarly are under development. While many HIV patients today are helped by highly active antiretroviral therapy, or HAART, many become resistant to the ...New multidisciplinary research tops chemists' meeting Aug. 22-26
...roteomics, metabonomics may lead to more efficient drug discovery and individualized patient treatment. Chemists will share new results and discuss industry trends. The ACS Divisions of Analytical Chemistry and Chemical Toxicology are sponsoring the symposium. Other symposia and topics on the Philadelphia...Molecule that 'blocks' key bacterial enzyme may lead to new antibiotics
...e stage for the development of novel antibacterial drug designs." To understand how MccJ25 works,... resistant to MccJ25 also showed resistance to the drug in a test tube. In their current work, these researchers used biochemical methods to characterize, i...Researchers make promiscuous animals monogamous by manipulating genes
...evious research linking social bond formation with drug addiction, also associated with the reward center ...ormation of romantic relationships are involved in drug addiction. "The brain process of bonding with one's partner may be similar to becoming addicted to d...Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
...ments are often toxic, and there hasn't been a new drug approved for lupus in 40 years. The Lupus Research Institute is leading the advancement of new science to prevent, treat and cure lupus. More information about the Lupus Research Institute is available at www.lupusresearchinstitute.org ....Small RNA surmounts large cancer problem
...enhance cancer treatment even in a situation where drug resistance has developed. Small interfering RNAs ...generally treated with a commonly used anti-cancer drug called imatinib, which is a small molecule protein inhibitor that blocks the activity of the protein...JCI table of contents, 15 June 2004
...enhance cancer treatment even in a situation where drug resistance has developed. Small interfering RNAs ...generally treated with a commonly used anti-cancer drug called imatinib, which is a small molecule protein inhibitor that blocks the activity of the protein...Breast cancer patients failed by treatment with taxol and taxotere respond to abraxane
...nnual meeting demonstrate that the investigational drug Abraxane TM (albumin nanoparticle paclitaxel), ad...ears that Abraxane allows for more cancer-fighting drug to be given to a patient, more of that drug to actually reach the tumor site in the body, and more o...Existing drug may prevent brain injury and seizures in newborns
An existing drug already approved by the FDA may protect newborns f...drocytes. "The finding that treatment with a drug prevents injury when given after the insult is tremendously significant," says Jensen, of the Depart...UCLA researchers recreate patterns formed by mammalian cells
...terns produced by cells, the researchers added the drug warfarin, which blocks MGP. The result was a double-striped pattern, also predicted by the simulation. This may help explain the known association of warfarin with birth defects. "The abnormal cell pattern resulting from adding warfarin, may give r...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...cterial cell walls. As the result of emergency of drug resistant bacteria, many of these are now under investigation as possible targets for new chemotherapeutic agents. More recently he pioneered in the discovery of the structures of both class I and class II human major histocompatiblity complex antig...NIH launches first center in Nationwide Chemical Genomics Network
...hemical "tools" for use in biological research and drug development. "Providing public-sector researchers ...s an effort to turn public sector researchers into drug developers," said NHGRI Director Francis S. Collins, M.D., Ph.D. "What we are doing is simply giving...Study finds that only half of a commonly used cancer drug is activated in cancer patients
...of gemcitabine to determine what percentage of the drug dose was associated with concentrations that excee...rprised to find that about half of the dose of the drug administered might not be converted into an active form. The implication is that alternative schedul...