Unnatural light-dark cycles expose duelling circadian clocks
...om jet lag or rotating work schedules might not be due to the desynchronization between the central brain pacemaker and downstream oscillators in the body, but rather from the uncoupling of oscillators within the central pacemaker itself....Molecular mechanism found that may improve ability of stem cells to fight disease
...at therapeutic potential for a variety of diseases due to their ability to replenish diseased cells and tissue. While they are unique in this ability, it remains a challenge to effectively treat disease long-term with stem cells because of our inability to grow them in the laboratory. Defining the molecu...Setting the gene expression base-line for breast cancer research
...ples, and discriminate between the genetic changes due to cell type differences and genetic changes due to cancer."Another important finding from the study was the identification of differences between lu...Solving the mystery of the dancer mice, and cleft lip too
... their heads abnormally, and have balance problems due to inner-ear damage caused by the mutation. For more than 35 years it's been known that these mice are also more susceptible than normal mice to being born with cleft lip and palate, while mice with two copies of the mutation are always born with the...UCSD finds genetic time bomb in heart that leads to heart failure in some patients
...e heart failure and in certain cases, sudden death due to cardiac electrical problems."One of these patie...d there is excessive expansion of the heart muscle due to BMP-10 expression, the small AV node is unable to keep up with the growth. The result is a misma...Experimental smallpox DNA vaccine protects primates from lethal monkeypox
...combinations of IMV and EEV immunogens are used is due to the targeting of different forms of the virus at different stages of infection and by different mechanisms. Hooper's colleagues on the study included Elizabeth G. Thompson, Catherine L. Wilhelmsen, Michael S. Zimmerman, Mohamed A. Ichou, Scott E...Tracking cystic fibrosis with mice
... unclear if all results are transferable to humans due to the difference in lung structure between mice and humans. Marcus Mall was funded with a DFG Research Fellowship in 2000 and is presently employed at the University of North Carolina in Chapel Hill. His current research results are published in th...Only half of recalled meat and poultry is recovered, study finds
..." he said. But the bigger, faster recalls are also due to more sensitive, more rapid tests developed in recent years. Hooker conducted the study with graduate student Ratapol Teratanavat. Their results appear in the April issue of the journal Food Control. The new regulations, called the Pathogen Reducti...Researchers discover cold virus can 'hit and hide'
...ildren who have suffered from bronchiolitis may be due to virus hidden in the lung. Professor Openshaw says: "Some people may be 'carriers', able to act as a source of new outbreaks in children. If RSV is a 'hit and hide' virus, this could explain where this virus goes in the summer and where it comes f...U.S. President's budget proposal means 5-year cuts 'well below historic levels'
...NIH's $27 billion portfolio will see a modest rise due to increases in biodefense research. But funding for non-biodefense programs will fall by seven percent. Many R&D funding programs face steep cuts over the next five years: Department of Energy (DOE) programs will see dramatic decreases such as: ...Scientists correct cystic fibrosis defect in mice with turmeric extract
...hich thick mucous clogs the lungs and the pancreas due to problems with the secretion of ions and fluid by cells of the airways and gastrointestinal tract. Normal secretion depends upon the function of a protein called CFTR (cystic fibrosis transmembrane conductance regulator), which was discovered at Th...Genome-wide screen reveals new tricks of old genes
...f not many, of the genes from this screen would be due to problems other than faulty cohesion, the researchers knew. "We had to do something else to get a manageable starting point," says Warren. So, using a technique she developed to identify whether a gene's loss causes the genetic material to become ...Risk of preeclampsia rises sharply with increased pre-pregnancy body mass index
...bout half of the increased risk of preeclampsia is due to two factors that have long been suspected to play a role in its development: a heightened inflammatory response often associated with high body mass and elevated lipid values in the blood related to being overweight. Dr. Bodnar says understanding ...Sick Kids researchers look at viral triggers for multiple sclerosis in children
...ore easily, as children have fewer viral exposures due to their young age," said Dr. Brenda Banwell, the study's principal investigator, a Sick Kids neurologist and associate scientist, and an assistant professor in the Department of Paediatrics at the University of Toronto. The research team found that ...A multi-institutional study may offer clues for the treatment of some autoimmune diseases
...ts may be related to differences in the dGuo pools due to variation of cell turnover in these individuals. The plasma terminal half-life of BCX-1777 was 11.7 hr, but the half-life of the inhibition of erythrocyte PNP was much longer. In vitro experiments indicated that it might be as long as five days. ...New research explores 'early bird' and 'night owl' sleep patterns
...asures, strongly suggesting that the findings were due to genetic differences. The authors of "Circadian ...en strains. This suggests that these findings are due to genetic differences. Furthermore, the inverse relationship between the percentages of slow wave ...Vanderbilt's John Oates wins clinical research award
...creasingly recognized. This is in no small measure due to the leadership and vision of Dr. Oates and those he trained." Oates' distinguished career at Vanderbilt began in 1963, when he joined the faculty of the School of Medicine as an assistant professor of Medicine and Pharmacology. He served as direc...Colorectal cancer rates in African Americans equal with insurance parity
...ce coverage is equal, racial differences in deaths due to colorectal cancer in blacks and whites disappear. The new study, which appears in the March issue of Cancer Causes and Control, examined the effect of race on colorectal cancer outcomes in elderly Tennesseans with identical health care coverage a......ation of blood flow, and inflammatory disturbances due to sepsis. Treatments may address any of these potential causes that are modifiable in the ICU setting, he said....