New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs
... chromosome must be unraveled. If the machinery is duplicating the chromosome, the process of unraveling must continue along the entire molecule. St. Jude investigators modified the top and bottom ends of the C-shaped enzyme so that the tips of the open ends of the enzyme were pulled together and locked Top 1 i...Yeast helps researchers better understand Parkinson's mystery
...painstaking research, scientists have succeeded in duplicating the disease's most critical features in the most readily manipulated model organism in existence. In research published in this week's issue of the journal Science, a team from Whitehead Institute for Biomedical Research used common baker's yeast as ...Purdue developing less costly model for studying human disease
... knockouts are only possible in mice. Successfully duplicating the process in zebrafish would require much less time and money for researching gene function. "The big problem in producing knockouts in species other than the mouse has been that it's been impossible to keep stem cells viable so that they contribu...UGA scientists discover gene that maintains genome integrity by limiting DNA replication
...censing protein by removing it from cells that are duplicating their DNA. When CDT-1 is not degraded in replicating cells, its presence causes the re-initiation of DNA replication. The University of Georgia team used a technique called RNA-mediated interference (RNAi) to probe the function of CUL-4. The basis ...Cadmium studies suggest new pathway to human cancer
...umbers enough to replace dying cells. However, in duplicating the DNA mistakes are made with a frequency that organisms would not be able to tolerate, if uncorrected. Luckily, most organisms do correct these mistakes by efficient mechanisms akin to a computer's 'spellcheck.' One of these correctives is post-re...Researchers suggests a potentially damaging effect of extremely low frequency electromagnetic fields
...the next. The checkpoint in G1 prevents cells from duplicating their DNA if conditions are unfavourable, whilst the checkpoint in G2 stops cells from dividing when damage has occurred to the chromosomes (DNA). These checkpoints effectively police the process of cell division so that risk of damaged cells replica...Purdue to help NASA create life-supporting ecosystem in space
...ing, dish washing and other sources. "It's exactly duplicating what happens on earth," Mitchell said. "But to make sure that things cycle fast enough, you need some physical and chemical processes to help along the biological systems." Perhaps people will be living in such "biospheres" on Mars or the moon withi...NSF grant to grow methane-producing microbes in lab
...cidic bogs." If the Cornell researchers succeed in duplicating the carbon-rich, anaerobic, acidic conditions where the methanogens thrive, Zinder says, the hard-working bugs could have a future in bioengineering -- perhaps in bioremediation of contaminated sites or in the controlled production of methane. Among ...UCSF-led study points to pivotal, early event in cancer development
...an active cell cycle for several weeks -- growing, duplicating their DNA and then dividing - and then entered a placid state, or irreversible senescence, characterized by low DNA replication, lack of cell death (indicative of a cell in senescence) and genomic integrity. The epithelial cells also progressed th...... strand. Upon encountering damaged DNA, this duplicating enzyme usually stops in its tracks which is where...nstruction process, explains Livneh. The sloppy R1 duplicating enzyme may prove pivotal in this respect due to its ability to tolerate damaged genetic material. ...Review article highlights tiny motors driving cell division
... muscle, skin, branch and flower -- are constantly duplicating themselves. In that process, gene-bearing chromosomes inside each cell must separate into identical sets to form two daughter cells. A misstep in chromosome division can result in birth defects, such as Down's syndrome; developmental defects, such as..."Remote control research" a first for the U of L and National Research Council
... to his satisfaction. Siminovitch said the cost of duplicating such a state-of-the-art facility locally would be in excess of $2 million. The technology that he can now access is a direct benefit NRC's broad-based mandate to bring more research services to more institutions in a very innovative way. "Knowing ......middle-wave (MW) and long-wave (LW) opsin genes by duplicating anancestral MW/LW gene into a tandem gene array some 40 million years ago, anevent that conferred trichromatic vision on all Old World primates. In the Julyissue of Genome Research, Kanwaljit Dulai, David Hunt (both at the UniversityCollege London),......e sequences of geneticmaterial that are capable of duplicating and randomly reinserting themselvesinto the genome. Protein-coding sequences of retrotransposons are quite similarto some bacterial sequences, so are thought to be very old and therefore alsoimportant from an evolutionary standpoint. Based on dat...