With an eye on safety, UF experts explore cellular mechanisms of gene therapy
...is might occur would be if the new DNA was able to effectively switch on a previously silent tumor-causing gene." In studies in people and animals conducted during the past decade, UF scientists have never seen tumor development associated with AAV-delivered gene therapy, but they wanted to make sure that wasn't......his large award," said Mann. "It means that we are effectively helping people find new treatments for a wide variety of medical conditions." "The GCRC provides an engine to foster rapid progression of research into practical applications for improving human health," said Charles E. McCall, M.D., professor and v...Small streams contribute far more than previously thought to cleaning waterways
...greater care to insure that small streams can work effectively to clean the water will reduce the overall nitrogen load that makes its way into larger bodies of water. "It doesn't mean that you can ignore your sewage treatment plants, but if we can do better with our small streams and do some restoratio......led ASK1, a key player in apoptosis. "If we could effectively block the assembly of Nef and ASK1, it could lead ..., helping to "tip the balance in favor of the body effectively dealing with the virus," he said. Identifying such a molecule could lead to the development of a ne...Merlin tells when to grow and when to stop
...lar portion of CD44. This activated form of merlin effectively blocks further cell proliferation. The data presented in this paper has significant implications for the understanding of how merlin deficiency contributes to tumorigenesis. NF2 patients display multiple tumors derived from glial cells. This work sug...Mandatory nutrition labeling reduces high-fat purchases
...ful evidence that mandatory nutrition labeling can effectively change consumer choices, suggesting that it may influence purchases of other high-fat foods as well." By studying the bar-code data from supermarket scanners, he found that before the nutrition labeling law, the high fat, unlabeled salad dressings ac...In gene therapy first, scientists restore vision to dogs born blind
... get a response in a human-sized eye, that you can effectively treat enough of the retina to have an effect on the animal's visual function." Dr. Jean Bennett, a senior author of the Nature Genetics paper and a scientist at the F.M. Kirby Center for Molecular Ophthalmology at Penn's Scheie Eye Institute, said t...Ribosome insight could help combat antibiotic resistance
...ly that bind to and block bacterial ribosomes more effectively than they do human ribosomes. Dr Ramakrishnan continued: "Although these antibiotics were discovered several decades ago, we haven't understood in detail how they work." Recently, several groups of researchers have been developing high resolution...Key step in gene activation discovered
...in the process of rearranging the shape of a gene, effectively unlocking its genetic code. One is a molecule nicknamed "SWI/SNF" and the other is a molecular family nicknamed the "HATs." Like a pack of comicbook superheroes, each with a different power, the team of molecules that control the use of a gene's c...Progenitor cells can have protective effect against brain trauma
...d to date, there is no clinical treatment that can effectively treat the damage."......ailov and others. "Chemical turbulence can be very effectively controlled by our approach." In theory, said Ertl, director of the department of physical chemistry at the Fritz Haber Institute: "It may be possible to increase the selectivity of various reactions, to improve the yield of a desired product. There m...Welch honors Kornberg for insights into DNA transcription
...dge ultimately will allow scientists to apply more effectively the results of the human genome project to better understand disease. Today, The Welch Foundation announced that Dr. Kornberg will receive its 2001 Welch Award, a $300,000 prize given for lifetime achievements in basic chemical research, in recogniti...UF researchers reverse metabolic disorder in mice
...road to a cure: In male laboratory mice, they have effectively reversed the condition with a single treatment of gene therapy. The findings raise the hope that as the science progresses in coming years, people with the disorder will no longer have to shun so much of the typical human diet, including meat, fish, ...AIDS in Africa has potential to affect human evolution, UC Berkeley scientists report
...rcent. The shift in frequency of these genes would effectively lengthen the average latency by one year, from 7.8 years to 8.8 years. The frequency shift is primarily due to the opportunity for continued reproduction during the extra two to four years, allowing those with the resistant version of the gene, or al......predictable odours. Because flytraps need to work effectively in areas with complex combinations of smells, such...erfectly possible to use attractants or repellents effectively in areas where there is already a strong smell. The researchers concluded that using the proposed a...University of New Orleans researcher to head a nine university, three-year, $15.8 million project
... in the project. "This project will also help to effectively train students in a variety of areas pertinent to materials science," said Dr. John B. Wiley, UNO associate professor of chemistry, who is also a member of the AMRI/UNO team. The project will focus on the design and fabrication of electromagnetic m...UT Southwestern researchers show tumor-suppressor genes linked to insulin signaling
...produce and grow so quickly, gene functions can be effectively studied in less time than other animal models. "We found that the TSC genes are negative regulators of the insulin pathway because when we omit the TSC genes, insulin signaling increases, and thus results in larger cells," Pan said. "The opposite is ...Structural studies reveal how potassium channels are inactivated
...so explain why drugs that block potassium channels effectively have structural features that resemble the inactivation gate peptide. The structural resemblance can cause serious side effects. Antibiotics with these features tend to block potassium channels found in the heart and can cause arrhythmias, MacKinnon ...Nuclear waste disposal: A safer solution?
...t be confident that nuclear waste disposal will be effectively dealt with." One of the most common ways to dispose of highly radioactive waste is to use devices similar to water softeners called ion exchangers, which are either inorganic - mineral-type - compounds or synthetically produced organic resins. An ion......eluga sturgeon, which under CITES guidelines would effectively place an international trade ban on beluga caviar. In addition, the three groups are calling on consumers worldwide to avoid beluga caviar and to reduce their consumption of other Caspian Sea caviars during this crisis. If consumers do buy caviar, b...