Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF)....... According to a new study published in the August 15, 2004 issue of the journal Cancer Research, administration of cannabinoids significantly lowered VEGF activity in laboratory...Two-pronged attack targeting EGF receptor hinders cancer cell growth
Hitting the epidermal growth factor receptor (EGFR) both high and low with a combination of drugs for targeted cancer therapy curbs cancer cell growth more effectively than using the drugs each by themselves, researchers from the University of Wisconsin-Madison reported in the August 1 issue of the journal . ...... EGFR drives unregulated growth in many types of cancer, and the new molecular can...Expression of Rb2/p130 and VEGF could serve as potential liver cancer prognosticators
The expression of the tumor-suppressing gene Rb2/p130 and the protein Vascular Endothelial Growth Factor (VEGF) in hepatocellular carcinoma (liver cancer) could serve as important independent prognostic markers in determining the aggressiveness of the cancer, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine in the Center for Biotechnology at Temple Unive...EGFR: A molecular lab rat let loose in systems biology
SAN FRANCISCO -- Epidermal growth factor and its receptor system, or EGFR, is well-trodden territory in molecular biology. And it's no wonder. This is one critical community of proteins, responsible for everything from the development of insect eyes and the mouse brain to human heart and skin. When EGFR breaks down, cancer and other diseases crop up. ...... EGFR is the veritable lab rat of mol...VEGF gene transfer fails to help peripheral arterial disease patients
CHICAGO A gene-transfer study aimed at easing the pain and disability caused by blocked leg blood vessels -- via the injection of a gene to encourage the growth of new capillaries does not improve symptoms more than placebo, new results show.... ...But University of Michigan cardiologist Sanjay Rajagopalan, M.D. says that related strategies now being tested hold the potential to fulfill expecta...Blocking VEGF can enhance radiation therapy
.Blocking the action of vascular endothelial cell growth factor (VEGF), a.substance that encourages the growth of new blood vessels, can dramatically.increase the anti-tumor effects of radiation therapy report medical researchers.from the University of Chicago and Harvard medical schools in the July 15th.issue of Cancer Research. .This report adds to the mounting enthusiasm for combining drugs t...Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
. . .FREMONT, Calif., March 15, 1999 -- Abgenix, Inc. (Nasdaq: ABGX) reported today.in Cancer Research (Volume 59, Issue no. 6), encouraging results of preclinical.studies with its proprietary fully human monoclonal antibody, ABX-EGF. Developed.using the company's XenoMouseTM technology, ABX-EGF targets the receptor for.human epidermal growth factor (EGFr) which is overexpressed on many major h...