Images of 'tail' of protein needed for cell multiplication suggest anticancer drug targets
...to set off a cascade of biochemical reactions that eliminates the molecular brake controlling cell replication. In the absence of this brake, cell replication accelerates, and if left unchecked, could cause cancer. Until now, the function of the E2 tail was unknown, according to Brenda Schulman, Ph.D., an assis...Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal model
... of every 3,500 newborn boys. The genetic disorder eliminates production of the dystrophin protein, which is necessary for the structural support of muscle. Without this protein, muscles weaken to the point where the victim cannot survive. "By giving one single injection of this AAV vector car...Chemical Society announces EPA awards for environmentally friendly technology
... cultures saves energy, improves worker safety and eliminates tons of waste. Buckman Laboratories International, Inc. (Memphis, Tenn.) Recycling can be a sticky business when lingering adhesives on envelopes, magazine binding and other materials gum up the machines used by paper mills to turn recycled waste ....... Adding an entirely separate chromosome, however, eliminates this risk. And rather than being limited to one or two small genes, vast chunks of DNA can be added if desired. "For certain diseases it could be very useful to have the ability to deliver multiple therapeutic genes," says Gil Van Bokkelen, chief exe...UCLA scientists decipher how the brain retrieves and stores our oldest memories
...th a mutant form of a gene called kinase II, which eliminates the ability to recall old memories. The animals were trained to recognize a cage, then tested for their memory of the cage at one, three, 18 and 36 days after training. "We found that the mutant mice recognized the cage for up to three days after ...World's oldest modern hummingbirds described in Science
...s hummingbirds to hover in front of the flower and eliminates the need for a perch. "The remainder of the skeleton is also very hummingbird-like," Mayr said. Mayr noted, however, that today's hummingbirds have even more specialized hovering design. These ancient hummingbirds grew to about the size of the Rufou...Cells from adult bone marrow can be converted into brain stem cells for transplantation
...rom adult human bone marrow, called stromal cells, eliminates the ethical and logistical issues that arise with ...rted and transplanted into the same person's brain eliminates ethical issues and immune-system problems that can arise when the body rejects cells from an outside...Scientists seek cause for what makes good cell go bad
...ually meet their experimental needs. But averaging eliminates much of the information scientists need to understand individual variability. Like biologists, physicists also encounter widely fluctuating data in some of their experiments. This "noise" actually helps physicists determine the basic characteristics ...Research on inherited eye disorders uncovers new information about blood-vessel formation
...mpair vision at all to a severity of scarring that eliminates vision completely," said Nathans. FEVR is known to arise from defects in a gene known as Frizzled-4 , which codes for a protein receptor (Fz4). Although Nathans and his colleagues had studied the Frizzled-4 gene and the Fz4 protein, they did not k...New DVD 'virtual' microscope at UNC-Chapel Hill
...ccount support personnel. "The virtual microscope eliminates that need," Petrusz said. With about 160 medical students and 10 to 20 faculty, UNC's histology course needs nearly 200 slides of the same structures and of good quality. "This is a practical impossibility," Petrusz said. "But in the new system, ever...Despite confinement, crop genes can spread fast to wild
...reactions inside the plant cell that pulls out and eliminates the transgene once the plant no longer needs it. Another technique involves inserting the artificial gene near a gene that's bad for the plant under wild conditions, making it unlikely that the transgene, should it escape, will spread in the wild pop...Tumor cell-specific therapy shows preclinical promise
...toring p53 protein function in mouse cancer models eliminates tumors and dramatically increases survival of the animals. While past efforts to restore tumor suppressor function in cancer cells have focused on gene therapy, Dowdy and colleagues introduced modified p53 peptides (parts of the protein) into cancer...Mice cloned from olfactory cells
... genes. According to Axel, the cloning achievement eliminates one potential mechanism and narrows the possible ways in which a cell chooses one of thousands of receptor genes. The findings also demonstrate that the developmental changes are reversible. Axel said that the cloning technique should be broadly appl...K-State professor to give paper on potential impact of ag bioterrorism
...s not going to be a perfect system that completely eliminates risks. That's not possible. So we have to be prepared." Stack said the system will also be able to detect natural out breaks in plants such as karnal bunt of wheat or Southern wilt of solanaceous plants caused by the bacterium Ralstonia solanace...New reactor puts hydrogen from renewable fuels within reach
...ducts. The reaction takes only 50 milliseconds and eliminates the flames and soot that commonly accompany ethanol combustion. In a typical ethanol-water fuel mixture, one could ideally get five molecules of hydrogen for each molecule of ethanol. Reacting ethanol alone would yield three hydrogen molecules. So f...Online calculator improves analysis of chemical data
...those used to study the functions of proteins; and eliminates errors or bias that might be introduced by manually translating mass spectrometry peaks into final chemical results. For example, by using Mass Spectator's automated calculations, law enforcement agencies can increase confidence in chemical analyses ...Space technology in new technique to fight breast cancer
...stems. This dynamic process quickly highlights and eliminates conflicts already in the system at top-level design. In addition to the support obtained from ESA's in-house medical expertise, ESI also assisted Brunsveld van Hulten by organizing an international workshop, under the auspices of ESA, to consult ou...'Suicide proteins' contribute to sperm creation
...tosis, a highly controlled sequence of events that eliminates dangerous or unnecessary cells, contributes to a wide variety of developmental and physiological processes--in a developing embryo, apoptosis creates the space between fingers and adjusts nerve cell populations to match the number of cells they targe...Major mutations, not many small changes, might lead way to new species
...e the species of monkeyflowers distinct and nearly eliminates crossbreeding in the wild. In an experiment funded by the National Science Foundation, the researchers changed the region of a chromosome, thought to be a single gene, that affects the concentration of yellow pigment in petals of monkeyflowers. M. l...Imperial researchers show novel flu treatment eliminates symptoms in mice
...irus, they show in mice that their novel treatment eliminates symptoms by reducing the response of active T white blood cells by a third. Flu A is the type of influenza responsible for pandemics such as the 1919 outbreak of 'Spanish flu', which globally killed more than 20 million people. Unlike current attemp...