Telomere Loss Spells Trouble for Aging Mice
...at either end of DNAstrands -- are produced during embryonic development. They crumble away as cellsmature and divide, suggesting telomere erosion might somehow control aging. Butthe process had been studied only in cultured cells. By knocking out one of the genes for a telomere-making complex,telomera...New Gene May Help Scientists Understand More About How the Body Grows
...establishment of the head-to-tail orientation. The embryonic events that Dr.Sive studies happen very early in development; in human terms, they take placewithin the first three weeks after conception--before most women even know theyare pregnant. Finding the genes that participate in this process in allverteb...Statement Of The DFG Concerning "Questions Of Human Embryonic Stem Cells"
... and passed a statement concerning issues of human embryonic stemcells. In the last weeks this paper had been c...mbryo is prohibited in Germany. The preparation of embryonic stemcells (ES cells) from blastocysts is carried out for reasons other than thoseaimed at preserving......g their tissues develop from two primary layers of embryonic cells. Incontrast, tissues of the more complex "triploblasts" develop from three primarylayers of embryonic cells. Because information from the pre-Cambrian is sosparse, researchers don't know yet the details...Osiris Therapeutics Reports Key Findings in SCIENCE Verifying Existence of Adult Stem Cells
...ear difference between adult stem cells and either embryonic stem cells or stem cells derived from fetal tissue -- our stem cells are readily available from a small sample of patient-derived or donor-derived marrow. Burns continues, "We are developing multiple products based on adult mesenchymal stem cells. In...University Of Chicago To Host 'Evo-Devo' Symposium
... known as "evo-devo" studies thegenes that control embryonic development in different organisms to answerquestions about evolution. "This is a new field that has generated a lot of data that can allow usto go back and reexamine old questions we thought we knew the answers to," saysGregory Davis, a th......a place, where no expression is foundduring normal embryonic development. After several days of development,molecular and morphological analysis of the developing structures revealesinsights into the functions of those genes during normal develpoment. The results provide further insights into the genetic path...Researchers Discover Mechanism Of Cleft Palate Development
...artment of Anatomy, demonstrated that duringnormal embryonic development, docking of the molecule TGF-a with the EpidermalGrowth Factor Receptor (EGFR), results in the production of a class of proteinscalled matrix metalloproteinases (MMPs). Using "genetic knock-out" mice specially bred without the EGFR, the r......'s Hospital. The researchers placed brain cells of embryonic chickens into a culturecontaining only a small amount of magnesium. After five days, they added anothermeasured amount of magnesium, analyzing the cells 24 hours later for overallviability (the ability to live, grow and develop), apoptosis (disintegr...UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
...ase, but it is switched off in normal cells,except embryonic cells, so the enzyme is not manufactured. It is switched on intumor cells allowing them to divide uncontrollably and be immortal. The same investigators published a related paper describing the rules forattacking DNA targets with PNAs. That study app...Mouse Map Leads Way To Human Disease Exploration
...use's cells. Indeed, the error can even be seen in embryonic mouse cells,holding the promise of developing cures that could one day be carried out infetuses with Down Syndrome so that babies would be born without the disease. "We are quite excited," said Dr. Korenberg. "These are keys to the secrets ofhow huma...The mother of all cells makes an excellent lab guinea pig
...gy company in California believes that cultures of embryonic stem(ES) cells could screen out excessively toxic experimental pharmaceuticalsbefore they are tested on animals or people. ES cells have the potential to develop into any of the body's tissues.This has led some researchers to suggest that the...Gene triggers formation of sensory cells in the ear
... has discovered the generesponsible for triggering embryonic cells in the inner ear to develop intosound- and m...ation. "So, we went back to the earliest point in embryonic development, when thefirst hair cells begin to differentiate, and we found absolutely no hair cells,...Scientific team identifies gene critical in embryonic development
...entified a gene which appears to be criticalduring embryonic development. The gene, called SIL, governs formati...lectric current to insert a piece ofDNA into those embryonic stem cells. The added portion of DNA integrated withthe cells' own genetic coding, causing the loss ...Brown University research team finds keys to liver development
... mechanisms that initiate these unspecialized embryonic cells to beginliver formation. The researchers developed the techniques to sift through tiny fragments of tissue to identify the relevant signaling factors. In doingso, they found that the growth factors FGF1 and FGF2, and to some e...Schizophrenia possibly linked to early brain development
...lsexactly where to position themselves to form the embryonic forebrain. This isthe front part of the brain from which the cerebral cortex and adjacent brainregions arise. These regions include the basal ganglia, which controls movement;the hippocampus, which is important for memory; and the olfactory bulb. ...Jefferson scientists create first transgenic mouse model of hepatitis B-based liver disease
... immune system sees the virus as -- self -- during embryonic development. To solve this problem, Dr. Feitelson used severe combinedimmunodeficient (SCID) mice as viral hosts. These SCID mice lack critical immunesystem elements that normally would fight the virus. When the mice arereconstituted with a n...Transplant cells show capacity for mending nervous system
...Wisconsin-Madison. The work was accomplished using embryonic stem cells, ephemeral cells that arisewithin days ...lly. "This is the first study showing that embryonic stem cells can be used for brainand spinal cord repair in an animal model of a human neurological di......e used for research on human stemcells-- including embryonic stem cells that have already been isolated inlabor...t can give rise tomultiple tissue types-- include embryonic stem (ES) cells , embryonic germ (EG)cells , and adult stem cells . For years, hematopoietic ...Researchers develop first potential schizophrenia genetic animal model
... the mice in Chapel Hill by altering genes inmouse embryonic stem cells, implanting the cells in new embryos and thentransferring the embryos into foster mothers where they developed. They thenbred successive generations of the mice and showed that about 25 percent carriedthe mutation and displayed schizophren...