UCSD team determines cellular stress within body is critical
...ear factor of activated T cells 5 (NFAT5)/tonicity enhancer binding protein (TonEBP). This NFAT5/TonEBP protein is the only known mammalian transcription factor that is activated by hyperosmotic stress. Steffan N. Ho, M.D., Ph.D., a UCSD assistant professor of pathology and senior author of the paper in PNAS...Fox Chase discovery may help physicians diagnose, treat devastating childhood disease
...lex neuronal network needed by the intestine. "The enhancer sequence we have discovered is important for regul...s laboratory has studies in progress to locate the enhancer specific to the EDNRB pathway in pigment-producing cells (melanocytes), from which the serious skin ...Domesticated tree crops may be the 'future of forestry'
...e been used in any type of tree, he said. Gene and enhancer trapping are alternatives to classical approaches ...anging from decades to hundreds of years. Gene and enhancer trapping remove the need to produce mutant plants and instead identify genes based solely on their a...Study is another step in determining if curry can protect against Alzheimer's
...nd popular cooking additive, could be an effective enhancer of an enzyme that protects the brain against oxidative conditions. This research is an important first step in determining whether curry could be preventive agent against acute neurodegenerative conditions, or reducing the progression of chronic and...Bioreactor boosts chemical fermentation by 50 percent: study
...ic acid is often used as a preservative and flavor enhancer for a wide variety of cheeses and baked goods. In the chemical industries, it's used as an ingredient for dyes, perfumes, pharmaceuticals, herbicides, rubber, and plastic. With today's growing emphasis on organic or "all-natural" produ...Major boost for European zebrafish research
... Green Fluorescent Protein (GFP) controlled by the enhancer sequences of specific genes. Under UV light, tissues of these fish will light up indicating wherever the respective gene is active. A facility to knock-out genes that will provide European researchers with zebrafish mutants for specific genes on dema...JCI table of contents, 15 October, 2003
...tes recruitment of Groucho homolog/Transducin-like enhancer of split-1 (TLE1). The authors present functional analyses demonstrating the mutation-induced disruption of HESX1/TLE1 interaction and transcriptional repression in cultured cells. These results provide a striking example of a clinical disorder assoc...Rockefeller scientists identify 'natural' proteins that push stem cells to produce hair, not skin
...th a transcription factor known as Lef-1 (lymphoid enhancer factor). A transcription factor is a protein that can combine with other proteins (in this case, beta-catenin) so that it can turn certain genes in the cell's DNA on or off. The Fuchs lab found that in mice, Lef-1 is expressed (produced) in stem cell...Making sense of Marfan syndrome
...the result of the disruption of an exonic splicing enhancer (ESE), a DNA sequence within the FBN1 gene that increases splicing efficiency. The scientists discovered that other types of mutations that also disrupt the ESE can cause exon 51 skipping. The authors therefore conclude that FBN1 exon 51 skipping is ...Protein may play role in sex chromosome inactivation
...ight act as an insulator, blocking an unidentified enhancer from attaching to the Xist gene, preventing it from inactivating the chromosome. According to Lee, discovery of CTCFs involvement opens the way to understanding how the developing embryo chooses which X chromosome to inactivate. The next step is to ...Enzyme is crucial for production of plant growth hormone
...into the Arabidopsis genome DNA sequences called enhancer sequences that promote gene activity," said Chory, who is at The Salk Institute for Biological Studies. "Specifically, we were looking for mutants in the light-responsive pathway. One measure of the light-responsive pathway in plants is the length of...Caffeine in colas: 'The Real Thing' isn't the taste
...addicting and said it was added merely as a flavor enhancer for cigarettes. The same is being said for caffeine."In 1998, Americans guzzled 15 billion gallons of sodas, the equivalent of 585 cans for every man, woman and child. Consumption of soft drinks has more than doubled since 1975 and more sodas are c...UF researcher unlocks secrets of popular supplement creatine
...he side effects associated with the popular muscle enhancer creatine. Muscle cramping, heat illness and even kidney problems have long been rumored to be associated with taking the supplement, but previous studies couldn't explain these problems. Now, in a study funded by one of the largest grants ever awa...Mayo Clinic study shows dietary supplement may help fight heart disease
...arginine -- touted by the supplement industry asan enhancer for everything from athletic to sexual performance -- improves chestpain symptoms in patients with early heart disease. "Our study showed that patients who took an L-arginine pill every day for sixmonths had significantly less chest pain and improved...Jackson Laboratory Researchers Identify Neuromuscular Degeneration Gene
...rotein-2), GF1 (glial factor 1), RIP1 (rat insulin enhancer bindingprotein 1), or Catf1 (cardiac transcription factor 1), the new findings are thefirst indication of an essential role for the protein in motor neuron functionand survival. Proteins in the DNA helicase/ATPase family to which SMBP2 belong...... transmitter release sites. There it acts as an enhancer of the release process, as U. Ashery and J. Rettig, two electrophysiologists in the group of Erwin Neher at the Max Planck <font face="Times New Roman">Institute for Biophysical Chemistry, Gö<font face="Times New Roman"&#......that neurotrophins are not simply a general growth enhancer for neurons, but represent a sort of chemical "language" that specifically regulates how different kinds of neurons develop. In their experiments, the scientists provided different neurotrophins -- NGF, BDNF, NT-3 or NT-4 -- to slices of infant ferre...