JCI table of contents, 15 March 2004
...eoporosis therapy. TITLE: PPAR-gamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors AUTHOR CONTACT: Hiroshi Kawaguchi The University of Tokyo, Tokyo, Japan. Phone: 81-3-3815-5411 ext. 30473 or 33376 Fax: 81-3-3818-4082 E-mail: kawaguchi-ort@h.u-tokyo.ac.jp View...Gene required for formation of blood cells
...d cells during embryonic development. The research enhances our understanding of the genetic pathways that are critical for normal blood cell generation. The results of this study are also likely to provide clues about the genes that play a central role in diseases characterized by pathological overproduction...Scripps scientists describe dangerous cocktail of alcohol, brain peptides, and neurotransmitters
... Previous studies have also shown that alcohol enhances GABA neurotransmission in the amygdala, the so-called pleasure center of the brain. Interestingly, the brain corticotropin releasing factor (CRF) stress system also increases GABA transmission in the amygdala. CRF is a common peptide in the b...Inhibition of insulin-like growth factor receptor-1 as promising anticancer therapeutic
...1R suppresses tumor growth, prolongs survival, and enhances the antitumor effect of chemotherapy in clinically relevant mouse models of multiple myeloma and other hematological malignancies. The researchers also identify two small molecules that are selective inhibitors of IGF-1R and are active anticancer ag...Lake restrictions make lakeshore property more valuable
...t preservation is valuable economically because it enhances the worth of land surrounding restricted lakes. This positive connection between the environment and economics could encourage more people to respond collectively to ecological change in northern Wisconsin, notes Provencher: "Economics is the languag...Small amounts of alcohol or anesthetics may damage the developing brain
...ocess known as long-term potentiation (LTP), which enhances communication between neurons by promoting the movement of the chemical messenger glutamate between brain cells. In normal rats, the stimulus Zorumski used usually produces a lasting 40 to 50 percent enhancement of glutamate transmission. But rats ex...AGU journal highlights - 6 January 2004
...18622, 2003 ------------------- 9. Coastal mixing enhances mercury levels in coastal ecosystems The mixing processes in estuaries may contribute to elevatedconcentrations of reactive mercury in coastal ecosystems. Rolfhus etal. collected multiple samples from the Connecticut River estuaryand found that the...JCI table of contents, January 2, 2004
...in Zhi Huang (YZH) activates a liver receptor that enhances the clearance of bilirubin. YZH was "boiled down" ...hototherapy." TITLE: A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR AUTHOR CONTACT: David D. Moore Baylor Co...A little stress may be good for you
...er accumulation. Mutations or environmental stress enhances protein damage. If misfolded or damaged proteins accumulate beyond a certain critical point, neurodegenerative diseases such as Huntington's, Parkinson's, Alzheimer's and Lou Gehrig's diseases can result. Morimoto and Morley studied C. elegans,...Can EPO prevent loss of brain function in schizophrenia?
..., and (3) peripherally administered erythropoietin enhances cognitive functioning in mice in the context of an aversion task involving brain circuits believed to be affected in schizophrenic humans. First results of the multicenter trial running in Germany will be available in 2004....Unraveling a protein, researchers uncover mechanics of anti-cancer agent
...chemically active groups. Once exposed, anastellin enhances the ability of the proteins to form networks. "The cells use anastellin apparently when it arises in half-unraveled FN-III-1 to strengthen the glue effect of the matrix," said Mu Gao, a doctoral student studying with Schulten at Illinois. "Anastellin...UC San Diego to host two-day conference on 'sustainable development' Dec. 11 & 12
...ise the sources of their materials and markets; it enhances understanding of environmental costs, including the benefits of working toward zero-waste; and it encourages long-term rather than short-term objectives." The first day of meetings, hosted by UCSD's Jacobs School, will focus on expansion of existing ...Study unearths cliques in the food web
...am."Understanding food web stability significantly enhances ourunderstanding of ecosystems which, of course, helps biologists andmanagers in their efforts to protect and improve the system. "With future applications based on this research, we may find thatmanagers should also focus on maintaining compartmen...Social mothers appear to be better mothers
... pecking orders. In many primate groups, high rank enhances reproductive success. Nevertheless, the researchers found that strong social bonds improved infant survival, regardless of the mother's position in the pecking order. Because droughts and other ecological conditions also affect reproductive performan...Estrogen receptor-a disruption and vasodilation in coronary arteries
... disease in healthy postmenopausal women. Estrogen enhances endothelial function of the coronary arteries, and this may contribute to the cardioprotective effects of the female hormone. The precise mechanisms that mediate the beneficial effects of estrogen on arterial endothelial function are incompletely und...Sex a necessary evolutionary commodity, new study shows
...ts that sexual reproduction in the worm C. elegans enhances the developmental flexibility of progeny, allowing them to change their sex and genetic makeup after birth to confer a critical advantage for survival when times are hard. In this species of worm - long a workhorse of modern genetics and developmenta...JCI Table of Contents, November 3, 2003
...ion of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance AUTHOR CONTACT : Terri M. Laufer University of Pennsylvania, Philadelphia, Pennsylvania, USA. Phone: 215-573-2955 Fax: 215-573-7599 E-mail: tlaufer@mail.med.upenn.edu View the PDF of this article at: https...Research finds tumor preventive qualities, damage reversal, in green tea
...effectively inhibits phase I enzyme activities and enhances the phase II enzyme activities," said Jia-Sheng Wang, M.D., Ph.D., of the Texas Tech University System, and lead investigator of the study. "At the same time, we see the value of green tea polyphenols in reducing excretion of 8-OHdG. All of this i...President Bush names Rutgers' Evelyn Witkin for nations highest science honor
...ates at least 40 genes that promote DNA repair and enhances individual and population survival. We now know that humans and many other organisms use the same kinds of DNA repair mechanisms. Witkin came to Douglass College in 1971 and taught in the department of biology for 12 years. She then spent eight ye......ncy in certain transplant recipients. TITLE: IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation AUTHOR CONTACT: Marcel R. M. van den Brink Memorial Sloan-Kettering Cancer Center, New York, New York, USA. Phone: 212-639-5606 Fax: 917-432-2375 Email: vanden...