Are we mice or men? Gene mutation linked to improving heart failure in mice proves lethal in humans
... failure by"knocking-out" the PLN gene and thereby enhancing calcium cycling. However,the effect of inhibiting PLN in cases of cardiac hypertrophy (which canprogress to heart failure) was unknown. In the first study, the researchers studied two mouse models of cardiachypertrophy in which mice destined to deve...New hints into development of osteoporosis
...osteoporosis, and these effects can be reversed by enhancing a protein called macrophage-colony-stimulating factor (M-CSF), according to research at Washington University School of Medicine in St. Louis. The study appears in the first March issue of the Journal of Clinical Investigation and is published onlin...Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
...ty to focus specifically on targeted cancer cells, enhancing their safety and reducing side effects for the patient. Dr. Bartlett has been developing preliminary data and rationale for the past three years. His next step will be to develop and test these agents in the laboratory to cure ovarian cancer i...Worlds leading journal editors urge self-governance and responsibility ...
...ing technological advances and economic growth and enhancing global stability and security, the editorial group noted. But, long-standing concerns about the risk of good science falling into the wrong hands were brought into clear relief by the events of September 11, 2001. What is potentially dangerous scienc...A decade later, gene discovered by Temple researchers found to be multi-functional
...we are able to promote myogenic differentiation by enhancing the myoD function, says Giordano, who also discovered the tumor suppressing gene Rb2/p130. Our studies demonstrate that in human tissue, cdk9 is a very important player in specialized tissue, such as muscle or lymphoid tissue. Another importan...Targeted immunotherapy eradicates cancer in mice
...levant numbers and extend their viability, thereby enhancing their therapeutic effectiveness and enabling them to eradicate disease, in this case a B cell tumor," said Dr. Sadelain. The researchers also tested the genetically modified human T cells (or lymphocytes) in vivo. They established a mouse mode...New findings confirm male fertility declines with age
...ors. It also included larger numbers of older men, enhancing the ability to detect an association between age and semen parameters. The researchers found that semen volume fell by 0.03ml per year of age, motility decreased by 0.7% per year, progressive motility decreased by 3.1% per year and the total progress...Common pediatric anesthesia drugs cause brain damage and learning and memory problems in infant rats
... glutamate system. Other anesthetic drugs work by enhancing the inhibitory activity of GABA (Gamma Amino Butyric Acid). GABA is the primary inhibitory transmitter in the brain. In related research, Olney and colleagues in Germany demonstrated that when the developing brain is exposed to drugs that block NMDA...Newly discovered cellular process helps cells respond to DNA damage
... contribute to the vast majority of human cancers, enhancing the response of cells to DNA damage could reduce cancer development, Kastan noted. Therefore, the discovery of how ATM is activated could help guide the development of ways to improve cellular responses to DNA damage, including responses to oxidative...UC Riverside receives $1.25 million from W. M. Keck Foundation
...lants, insects, and pathogens that is essential to enhancing the world's food supply." "The award is an important validation of our activities at the Genomics Institute," said Michael Clegg, director of the Genomics Institute and Distinguished Professor of Genetics at UC Riverside, "especially because it comes...Rice develops nanosensor for precision chemical analysis
...erties of nanoshells. Nanoshells are so useful for enhancing SERS and for other applications because of their size and precise structure. Nanoshells are just slightly larger than the size of molecules, measuring just a few tens of nanometers, or billionths of a meter, in diameter. Tuning the properties of nano...Clinical study results published in NEJM show promising data on Antegren (natalizumab)
...ed during the treatment period. A mean of 9.6 new enhancing lesions developed during the treatment period in the placebo group (n= 71) versus 0.7 and 1.1 in the 3 mg/kg (n= 68) and 6 mg/kg groups (n=74), respectively. There was a reduction of approximately 50% in the number of patients experiencing a relaps...URI biologists study predator-prey relationship between sand shrimp and flounder
...irectly influence the physiology of sand shrimp by enhancing metabolic activity and thus increasing their predation of juvenile winter flounder. "Investigating the effects of changes in temperature on population dynamics is increasingly important given the anticipated effects of global warming on marine and e...Children's Hospital Boston researchers regenerate zebrafish heart muscle
...ch isn't proven, but is quite exciting, is that by enhancing human cardiomyocyte proliferation after heart injury, one may be able to enhance cardiac regeneration and reduce cardiac scarring." In the experiments, Keating and co-authors Kenneth D. Poss and Lindsay G. Wilson, also of HHMI and Children's Hospita...Bush signs; ozone treatment for ballast water; wetland restoration template goes national
...stand their watersheds, and develop strategies for enhancing or restoring them. In turn, WSEP has grown into a national Sea Grant program. This joint program of the Oregon, New York and Louisiana Sea Grant programs is making the educational material developed for WSEP available to programs across the country. ...Versatile immunosuppressant drug may have new role in radiotherapy for cancer
...our cell proliferation, may have yet another role enhancing the effectiveness of radiotherapy for cancer patients. Research in mice at the Mayo Clinic in Rochester, Minnesota, has shown that rapamycin boosts the therapeutic effect of radiation by delaying the regrowth of brain tumours after treatment. Their f......f thinning were conducted with a long-term goal of enhancing forest biodiversity." In these research projects, the USGS and OSU scientists contrasted the responses of plants and animals in three types of forest stands in Western Oregon: young stands thinned by commercial techniques 15-20 years ago, young unthi...Pre-clinical studies identify novel ways to enhance effect of chemotherapy
...in tumour stroma cells could be a novel method for enhancing the effect of chemotherapy. If future clinical trials based on these experiments show the same results that we have seen in animal models, then we have identified a new and possibly widely applicable strategy for improving drug treatment for cancer p...World's largest scientific society convenes regional meeting in Charleston, S. C., Nov. 13-16
...sics Presenter will introduce new techniques for enhancing students' interest and excitement in chemistry through the utilization of forensic investigations using gel electrophoresis units designed to run on 9-volt batteries. (Pat Ryan, Carolina Biological Supply Company, Biotechnology/AP Biology, Burlington......ould be treated with therapeutic agents capable of enhancing synaptic plasticity and learning." "In addition," Goodlett suggested, "future human studies might use functional neuroimaging techniques to begin to explore whether children that have had confirmed prenatal alcohol exposure, but who do not meet the d...