Required activation 'cascade' identified for p53 tumor-suppressor protein
...ficiency as a transcriptional activator and almost entirely abrogated its ability to arrest the cell cycle," says Wistar staff scientist Nickolai A. Barlev, Ph.D., lead author on the Molecular Cell study. "This was the first direct evidence that acetylation is critical for p53's function." "While we saw no ef...Prizes awarded in the 2002 Gottfried Wilhelm Leibniz Programme
...of folklore and linguists. But he has also entered entirely new research terrain, including urbanity research, technology research and examinations on the culture and history of semi-luxury foods and tobacco. Not only is Thomas Hengartners work consistently interdisciplinary, but he also makes an effort to pr...Introducing the biology of the future
...networks of protein interactions. The result is an entirely new catalogue of the enormously complex relationships between over 1,400 yeast proteins about a third of the genome. The researchers discovered 232 multi-protein machines, 134 of which were totally new. They also found new components lurking in near...Researchers find gene involved in pain relief
... involved in pain modulation that could lead to an entirely new approach to pain control. The results of their...o-oxygenase. The DREAM gene, however, works in an entirely different way by binding directly to DNA and regulating the expression of a protein in the endogenou...URI oceanography models migration and foraging strategies of North Atlantic right whales
...ournal of Cetacean Research and Management devoted entirely to right whales, copepod densities of that magnitude have rarely been measured in the North Atlantic. Although the actual extent of such high-density zooplankton patches in the western North Atlantic is very poorly known, some of the highest densitie...Other highlights in the Jan. 16 issue of JNCI
...n in the United States, 2 million of which are not entirely normal. Most Pap tests that are not clearly normal show equivocal (aytpical squamous cells of undetermined significance [ASCUS]) or mild (low-grade squamous intraepithelial lesions [LSIL]) abnormalities. Only about 5% of women with ASCUS and 10% of ...Images reveal how body regulates salt uptake in cells
...17, 2002, issue of the journal Nature , reveal an entirely new type of protein architecture designed to be an...ein subunits that make up the channel are arranged entirely differently in the two types of channels. In the potassium ion channel, four protein subunits contri...What remains to be discovered in Central American forests
...thing to have a collection, and it's another thing entirely to use it to learn about the past, present and the future of the forest. A collection of coins hold many secrets, the mix of metals used to mint a penny tells you about metal availability, wars and shortages, new supply sources. Likewise, a plant c...Growth factor receptor signaling critical to intestinal tumor development, studies show
...sentially normal lives, Roberts said. Rodents with entirely dysfunctional Egfr die within two weeks of birth, which shows the gene is essential for life. Related work conducted in Coffeys laboratory at Vanderbilt involved placing human tumors in mice and then treating the mice with Egfr tyrosine kinase inhib...Folding upon binding: unique protein activation mechanism found by scientists at TSRI
...that have either large unstructured regions or are entirely unstructured and yet are biologically functional, and there is growing evidence that much of biology is carried out by these "intrinsically unstructured proteins." The structure, solved by Wright and his colleagues through nuclear magnetic resonance...High tech movies reveal information transfer within cells
...of fusion. "We see that yeast vacuoles fuse by an entirely different mechanism than what had been postulated," said Wickner. "There does not appear, as many assumed, to be a single expanding diaphragm between two vacuoles which might have allowed the contents to flow together as the diaphragm opens. Rathe...Merck/AAAS announce 2002 winners for Undergraduate Science Research Program
...957 by Merck & CO., Inc., the foundation is funded entirely by the company. The mission of the foundations is to advance biomedical science training and education and to improve health care worldwide. Since its inception, more than $254 million have been contributed by the Foundation to support biomedical e...Study suggests gum disease, cardiovascular disease link common phenomenon in developed countries
...edicine and lead author on the study. "This is an entirely different population with a different genetic profile."But we found the same bacteria, which supports our earlier studies indicating that oral infection plays a role in atherogenesis. " The study of pathogenic burden involved samples from seven parti...Enzyme once thought harmful to Alzheimers patients now appears key to future treatment
...uld cause increased release of ACh, which would be entirely consistent with the effects of nerve growth factor on cholinergic function. An important consequence of the findings presented here relates to the development of galanin antagonists, which have been promoted as a possible treatment option for AD. Ou...Experimental Biology 2002, Translating the Genome
...h scientists armed with the viewpoint and tools of entirely different disciplines. The seven sponsoring societies for Experimental Biology 2002 are: The American Physiological Society, American Society for Biochemistry and Molecular Biology, American Society for Pharmacology and Experimental Therapeutic...Researchers discover new mechanism that targets and destroys abnormal RNA
...mediated decay. We found that nonstop decay was an entirely new mRNA turnover mechanism that had none of the properties of nonsense-mediated decay, or of normal mRNA turnover in the cell, said Dietz. Additional experiments showed that the same nonstop decay mechanism found in yeast was also conserved in mamma...Researchers develop blood test to diagnose Alzheimers-type changes in mice
...to 20 years before symptoms arise. For reasons not entirely understood, potentially dangerous amounts of a protein called amyloid-b (Ab) begin to build up in these individuals. If enough Ab clumps together in the brain, it forms amyloid plaques, a key feature of Alzheimers disease. Brain plaques are somewhat...Forging a link between brain and bone
...asts the genesis and control of osteoporosis in an entirely new light....New method used to transfer genes into mouse
...ified mouse. "This is a new type of technology, an entirely different way to make genetically modified animals," said David Largaespada, Ph.D., an assistant professor in the university's department of genetics, cell biology and development and director of the University of Minnesota Cancer Center's Genetic Me...Scientists find they can tap gene-silencing process to reveal parts of genetic machinery
... the mechanism. Once that process is mostly or entirely understood, scientists should be able to turn off gene expression at will, including genes responsible for cancer and various genetic disorders....