Adding vitamin C to certain drugs may help treat Alzheimers, other brain disorders
...e their transport across these receptors and their entry into the brain. To test their theory, the researchers studied three different compounds that are used to treat brain disorders ranging from epilepsy to Alzheimers but are known to have difficulty crossing the blood brain barrier. Those compounds ar...... of Cellzomes approach include: Identifying novel entry points for drug discovery that are based on the in vivo isolation of molecular machines under various experimental conditions Providing a platform on which to load other data and information to power an in-silico based approach to experimental desig...Protein study suggests ways to help humans thwart viruses
... to the receptor used for viral entry. By blocking entry to the virus, the protein shuts down the virus' ab... such a gene into cells would protect cells at the entry step and, if virus happened to make it in, it would reduce the infectivity of new viruses manufactur...Genetic protection against fetal alcohol syndrome?
...l entry. Some FAS children may never reach school entry because of major birth defects. Two, FAS is the tip of the iceberg. Thus, the number of school children with fetal alcohol effects is likely exceedingly high." The term fetal alcohol effects (FAE) is used to describe individuals known to be expose...UNC-Chapel Hill gene therapy center awarded $9.2 million from NIH
...rcoming inefficient gene delivery related to virus entry into cells and the persistence of expression of the transferred gene. These studies are aimed at generating new knowledge about the safety and biological efficacy of gene delivery, which will be of importance to the design of future clinical trials. ......n register the movement of fish through a point of entry to a wetland. It consists of three electrodes running across the waterway. As a fish passes over them, the electric field between them is affected, revealing the direction and speed of a fish's movement as a trace on a monitoring computer screen. ......eled with only one dye molecule, on its infectious entry pathway into a living cell," explains researcher C...ed. Clearly, however, the virus was trying to gain entry to the cell. In 13 percent of all approaches having membrane contact (43 of 339 trajectories) the vi...UI researchers and colleagues identify genetic changes in bacterial biofilms
.... These include genes for proteins that hinder the entry into cells of aminoglycosides, a particular class of antibiotics. The ability to hinder antibiotic entry to cells is a major resistance mechanism used by P. aeruginosa. In addition to these, the list conta...Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved
...viral proteins that hijack these receptors to gain entry into cells. There are many different types of integrin receptors, all with similar structural motifs. Some of these play important roles in other diseases, such as stroke, heart attack, diabetes, and rheumatoid arthritis. "This work will help resear......o-receptors that the virus must latch onto to gain entry into a cell. Hildreth believes that in the absence of cholesterol, a rigid substance, these receptors lose their shape, become unstable and are destroyed. Cholesterol's stiffening quality is actually responsible for the name "lipid raft." This fatty ...New mutant mouse repositories established for biomedical researcher community
...the MMRRCs to give the research community a single entry point to the network through the MMRRC Web site at www.mmrrc.org. This site provides information about submitting candidate strains. By late 2001, the site will also provide detailed phenotypic and genotypic information to researchers interested in ...Research team unlocks secrets of the firefly flash
...photocytes they also act as gatekeepers for oxygen entry into the cell interior. Mitochondrial respiration prevents oxygen from reaching the light-producing chemicals which are sequestered in the photocyte interior. The situation changes dramatically when a nerve signal arrives and stimulates cells to beg......nternalin interacts with E-cadherin to promote the entry of Listeria into intestinal cells. Listeria ca...lled cavity that surrounds the bacterium after its entry into the cell. A pair of enzymes, PI-PLC and lecithinase, also help free Listeria from the vacuole...Scientists record extraordinary sounds made by minke whales
...calls it the "star-wars" vocalization; his logbook entry after first hearing the sound, which resembles a laser-gun sound effect, was simply "Star Wars!!??" Gedamke and Costa, a professor of ecology and evolutionary biology at UC Santa Cruz, worked with Andy Dunstan, a scientist on the research and ecoto......ve proven effective in preventing HIV from gaining entry into human cells. The research will expand upon the discovery that using an HIV coat protein could be valuable in creating a vaccine for HIV. The partnership announcement comes on the 20th anniversary of the first identified HIV cases by the Centers ...... molecular pores in cells. These pores control the entry and exit of substances such as sodium, potassium a...ngs suggest that ADP-ribose is able to control the entry of sodium and calcium into cells that have LTRPC2 channels. This finding holds potential medical sig......hat may help explain the different timing of their entry into inflamed tissues. Now, Panina-Bordignon and coworkers have studied the expression of chemokines and chemokine receptors in the inflamed airways of asthmatic subjects. They find that two Th2-restricted chemokine receptors, CCR4 and CCR8, are upre...University of Washington professor's new book seeks to rewrite understanding of cell biology
... How, for example, can channels that allow the entry of large molecules exclude all smaller ones? And pumps require energy. Sodium concentrations are lower inside cells than outside, for instance, and scientists have proposed a sodium pump to help maintain that equilibrium. But the sodium pump alone...Janet Ginsburg receives microbiology communications award
...gy (ASM) Public Communications Award. Her winning entry "Bio Invasion," an article on the potential threats of foreign disease that appeared September 11, 2000, examines the dangers when deadly pathogens, expanded global trade and travel are mixed with limited inspection and surveillance. Halting trade a...Hopkins' Young Investigators' Day winners shine in the spotlight
..., C. elegans. Specifically, he's shown that sperm entry into an egg triggers formation of microtubules in the embryo that, in turn, direct the rearrangement into a definite head and tail end of the developing animal. Clifford R. Weiss has shown the potential for magnetic resonance imaging in pinpointin...