Wistar Scientists Identify New Tumor Suppressor Gene For Breast And Lung Cancer
...laboratory of Dr. Frank J. Rauscher III, encodesan enzyme that helps to regulate levels of BRCA1, a gene known to causehereditary breast and ovarian cancers. Three years ago, scientists in Utah identified the BRCA1 gene, which was alandmark accomplishment in cancer research. The discovery of BRCA1 made itp...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
The proteasome is the central enzyme of the ATP-ubiquitin-dependent proteolytic pathway. It is responsible for the elimination of abnormal proteins, arising from mutations or damage ensuing from adverse external conditions. Moreover, it has important regulatory roles in n...USC Study On Soy's Anti-Cancer Effects
...biochemical toolbecause of its ability to block an enzyme (tyrosine kinase) important in cellgrowth and differentiation. In earlier studies, Lee had found that it could alsoblock the stress response. "But until now the targets of genistein action havenot been well understood. Our work provides a molecular m...Nitrate Reductase: A Magical Enzyme?
... reductase. They want tocreate a 3-D model of the enzyme to gain understanding of how it works. C...tually every plant on earth and is a veryefficient enzyme with an important job in nitrogen metabolism in plants,according to Campbell. The problem is--plants...New fluorescence technique for ultra-sensitive enzyme characterization developed - Screening catalyti...y, precise analytical techniques for monitoring enzyme functions are indispensable tools for the understanding of biological phenomena at the molecul...Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
...he disease is caused by a genetic flaw in which an enzyme fails to be produced. The disease is incurable, re...iruses, to deliver the genetic information for the enzyme into the brain. They have shown that the system works in the lab and in animals. They then showed i...Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat
...E, N.M., March 20 -- Sex-related differences in an enzyme thatbreaks down blood fats -- particularly "bad ch...ed in the past that there are higher levels of the enzyme hepaticlipase in men than in women. We asked the question, does hepatic lipase accountfor these lip...Genetic Make-Up May Determine Response To Cholesterol-Lowering Drugs
...y variations in thegene for lipoprotein lipase, an enzyme that plays a role in cholesterolmetabolism. Other scientists have found the lipoprotein lipase gene is tied toelevated cholesterol, insulin resistance, and severity of coronary arterydisease. Four to five years after entry into the clinical...American Museum Of Natural History Holds Symposium On Biodiversity And Human Health Issues
...y identified thermophilic bacteria that produce an enzyme that isrevolutionizing DNA and RNA research Speakers include: (Overview) Eric Chivian, Center for Health and the Global Environment,Harvard Medical School (Panel Moderator) Bruce Bean, Harvard Medical School Edson X. Albuquerque, Universit...Seeing How the Brain Changes During Aging
...eloped a radiotracer that monitors the level of an enzyme called MAO B thatbreaks down dopamine. Levels of MAO B increase as we age, contributing todopamine deficiency. A drug called L-Deprenyl inhibits MAO B and is used totreat patients with Parkinson's and Alzheimer's disease. Fowler says that thePET stud...Rapid Progress Reported On New Class Of Anti-Cancer Drugs
DALLAS -- An enzyme critical to activating the protein called Ras, whi...s more, the scientists say, drugs that inhibit the enzyme -- calledfarnesyl transferase (FTase) -- are proving in laboratory studies to effectivelyshut down c...Common Mutations Linked To Increased Risk Of Breast Cancer
Women with common variations in the class of enzyme known as glutathioneS-transferase (GST), which detoxify carcinogens, have an increased risk ofdeveloping breast cancer, according to researchers at the Johns Hopkins Schoolof Public Health. The scientists studied three GST genes, and found thatcerta......each mother was a carrier of atleast two 'at-risk' enzyme genotypes." "At-risk" genotypes are defined as variations in the genes coding formetabolic enzymes, resulting in increased activation or decreased detoxificationof cancer-causing toxins. The researchers also found that as women smo...Purdue Research Helps Keep Phosphorus Out Of Surface Water
...gs to absorb. In their tests, pigs fed the phytase enzyme and a low-phosphorus diet gained weight and grew j... manure. Manure from the pigs that ate the phytase enzyme held a balance of nutrients that more nearly matched crop needs, a balance less likely to leach phos...... factor- a <font size="3">-converting enzyme (TACE). TACE is a membrane-bound metal...y cell of the human body. This multidomain zinc enzyme has recently been identified to cleave the membrane-bound precursor of the tumor necrosis fact...Obscure Enzyme May Play Major Role In Heart Disease
...nd HAIFA, Israel, April 14, 1998 -- A little-known enzyme mayplay a significant role in preventing heart att...linical Investigation, reports that paraoxonase,an enzyme present in the blood, prevents the oxidation of low-densitylipoprotein or LDL, the "bad cholesterol"...Researchers Discover How Ulcer Bug Becomes Antibiotic-Resistant
...lori to break down organic nitrogen compounds. The enzyme also happens to convert metronidazole to hydroxylamine, which damages DNA, proteins and other macromolecules and kills the bacterium. So the bacterium changes a harmless chemical into a lethal drug. When the rdxA gene is inactivated by mutation, howe...Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
... treat inflammatory forms of arthritis by using an enzyme naturallyproduced by the human body. Researchers found that the enzyme neutral endopeptidase (NEP) couldreduce some of the effects of inflammatory arthritis, according to ...UCSF Researchers Identify Mutations In Gene Causing Hereditary Form Of Childhood Rickets
...enspecific forms of the mutation and the resulting enzyme activity. Ultimately,they hope to link specific errors in the enzyme to specific clinicalmanifestations in individual patients. "People have different degrees of......cted neuronal tissue. Moreover, the activity of an enzyme called caspase-3 was lower than normal in the BAF-treated rats, whereas it was three-to-five times higher in the control animals. "These results suggest that BAF protects brain tissue by inhibiting caspases and thus preventing apoptosis," Holtzman s...