Tag: "enzymes" at biology news
Research Indicates Molecule Sabotage May Slow Brain Cancer
...ogression," says Hockfield."Moreover, blocking the enzymes
that cut BEHAB in half also may be an effectivetherapy." In future work, the scientists plan to test the protein's value as atherapy component. They hope to find methods to block BEHAB's overall function,to reduce its production, and to inhi...
Rapid Progress Reported On New Class Of Anti-Cancer Drugs
...attempt to understand differences betweenthese two enzymes
that might aid development of specific inhibitors. However, still mysterious, say the biochemists, is why FTase requiresmagnesium to function, while geranylgeranyl transferase does not -- a differencethat might also offer clues to new inhibi...
Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers
...ody. The scientists alsostudied various metabolic enzymes
that process chemicals found in tobacco smoke. ...en smoked more heavily, the levelsof some of these enzymes
(CYP1A1 and CYP2E1) increased. CYP1A1 and CYP2E1transform substances in tobacco smoke into dangerou...
MSU Scientists Eavesdrop On Bacterial
... accelerate or slow down growth or to makespecific enzymes
that degrade toxic chemicals. Davies zeroed in on two chemicals, called homoserine lactones, in acommon biofilm maker called P. aeruginosa. P. aeruginosa is the No. 1 cause ofhospital acquired infections, the chief organism in burn and open-w...
Eviction From Scum Home Makes Disease-Causing Microbe Vulnerable
...using molecular biologytechniques like restriction enzymes
or "molecular scissors" tosnip the gene from the bacteria's genetic code. It was in Greenberg's laboratory at Iowa that Pearson, as amaster's degree student four years ago, first solved the chemicalstructure of the Pseudomonas autoinducer. Late...
Researchers Discover How Ulcer Bug Becomes Antibiotic-Resistant
...one, it can be activated by one of the bacterium's enzymes
to produce hydroxylamine, a mutagen and cancer-causing chemical." The collaborators describe their findings in the April 14 issue ofMolecular Microbiology. Hoffman's graduate student, Avery Goodman, is lead author of the paper. ...
Stanford Microbiologist Receives Lifetime Achievement Award
...he chemical structure of the six genes encodingthe enzymes
for protein biosynthesis and identified the precise chemicalinteractions between the regulatory proteins and nucleic acid sequences thatregulate the output of this set of genes. He discovered a regulatory mechanism for controlling gene expression bya...
Environmental Technology Breakthroughs Forecast -- Year 2008
...and biological products such as drugs,proteins and enzymes
for many uses. Producing chemical feedstocks, fue...dustry for theproduction of "extremozymes." These enzymes
expand the range of temperaturesand conditions used in manufacturing biotech products, creating oppo...
Naturally Produced Enzyme May Be Useful In Inflammatory Arthritis
...k-down. In healthy individuals, NEP is one of the enzymes
which controlsthe effects of such peptides, Ward said. Ward and his colleagues tested synovial fluid from the joints of threepatients with rheumatoid arthritis. The researchers then added NEP to thefluid and found that NEP decreased the negati...
Biochemist Solves Riddle Of Collagen Stability
...the molecular level, which makes it susceptible to enzymes
that cause it to degrade. The aging process or geneticabnormalities can cause this unraveling to occur, Raines said. Collagen is created by cells with a complex and repeated chain of amino acids, with different helices performing specialized tasks in...
UCSF Researchers Identify Mutations In Gene Causing Hereditary Form Of Childhood Rickets
...ermined thatthese mutations give rise to truncated enzymes
that are unable to carry outtheir catalytic activity. Six samples of the DNA were from French Canadians, among whom the disease iscommon. The UCSF researchers found that all of these individuals carried thesame mutation in the gene, and they have de...
Hormone Activators Stimulate Skin Growth In Fetal Rats Suggesting Possible Skin Treatment For Premature Infants
...ups lacked a well-defined SC. The activity of two enzymes
involved in theformation of the SC were also increased in fetal rats with activators. Finally, proteins associated with a mature SC and a competent barrierwere present in the rats injected with the activators, but not in the controlgroups....
Interdisciplinary Method Offers New Way To Study Ribozymes
...studies of metal-binding sites in ribonucleic acid enzymes
(ribozymes). "Ribozymes show great promise for gene therapy of viral diseases,such as AIDS, due to their ability to bind and cleave viral RNA targetswith the help of metal ions," said Yi Lu, a U. of I. professor of chemistry. "Studying the structure...
CAK Activation Of Plant Cell Cycle: Scientists Find Another Piece In The Jigsaw Puzzle To Help Explain Why Plants Do Not Develop Cancer Spontaneously
... In all eukaryotes, the cell cycle is regulated by enzymes
called cyclin-dependent protein kinases (CDKs). Plants harbour several different CDKs that are all related to their yeast and animal counterpart. Activation of the cell cycle at various control points requires the phosphoryl...
Mice Lacking The Pax8 Gene Suffer From Hypothyroidism And Fail To FormThyroxin-Producing Cells Of The Thyroid Gland
...es: the exocrine cells or acini, produce digestive enzymes
like amylase, trypsin, nucleases, etc., while the endocrine cells produce insulin, glucagon, somatostatin and other hormones. The generation of mice lacking Pax4 and Pax6, demonstrated that these genes are neede...
Inhibition Of A Novel Gene Involved In Phosphorylating Starch In TransgenicPotato Tubers Leads To The Repression Of Cold Induced Sweetening
...ch introduce the branch points. Other enzymes
are needed to determine the final starch structure... Even though many starch biosynthetic enzymes
are known, it has never been possible to synthesize semi-crystalline glucans in vitro, ...
Plants - Factories Of The Future
...these compounds. We have a good indication of the enzymes
that are needed, and potentially useful genes are ...e oils." This research has revealed a family of enzymes
that perform a range of chemical modifications to fatty acids. This knowledge should enable the te...
Neurogenetics Lab Scan Suggests Genetic Linkage On Chromosomes 4 And 11
...age to alcoholism resistance. One of two principal enzymes
involved in alcohol metabolism, ADH catalyzes the conversion of alcohol to acetaldehyde. High ADH activity produces excessive acetaldehyde, which can cause uncomfortable facial flushing, diminish tolerance, and thereby prevent drinking that might lea...
Gene May Hold Key To Treating Life-Threatening Cholesterol
...ociated with cholesterol tells LXR-alpha to signal enzymes
to increase the rate of cholesterol conversion to bile acid. Without LXR-alpha, this process doesn't occur, and cholesterol accumulates in the liver. Mangelsdorf said scientists have found a perfect drug target in LXR-alpha. He plans to look for w...
UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities
...g half the sperm head. Just before fertilization, enzymes
from the acrosome, activated at the proper time, s...its genetic material to fertilize the egg. If the enzymes
are released too soon, a process called premature acrosome reaction, the sperm is rendered useless. ...
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