International study findings link acne-like rash to effectiveness of new targeted cancer treatment
...ned to home in selectively on a protein called the epidermal growth factor (EGFR). EGFR is found on the surface of some cells and plays a role in regulating cell growth. Cetuximab interferes with the growth of cancer cells by binding to EGFR. It is approved by the Food and Drug Administration in the USA for us...Single isolated mouse skin cell can generate into variety of epidermal tissues
... to reject the cells, to see if new hair and other epidermal tissue will grow. As part of the Robert and Harriet Heilbrunn Center for Stem Cell Research that was established in August 2004 at Rockefeller, Fuchs' laboratory is among the six on Rockefeller University's campus that now conduct basic research wit...Skin stem cells give hairless mice hair
...sh and still have the capability to perform either epidermal repair or hair-follicle generation." To answer those questions, Fuchs and her colleagues first isolated stem cells from the bulge by fusing antibodies to characteristic cell surface molecules. "An important aspect of this paper was that we found we...APS awards more than $140,000 to minority students of physiology
...y of Arizona The focus of Ms. Clark's research is epidermal growth factor (EGF) and its role in protecting the intestine against a disease that affects premature babies, called necrotizing enterocolitis (NEC). Her lab has shown that supplementing EGF into infant formula reduces the incidence and severity of ...University of Pittsburgh receives $10 million grant for head and neck cancer
...ated in the proliferation of head and neck cancer, epidermal growth factor receptor (EGFR) and members of the G-protein-coupled receptor (GPCR) family. While both types are over-expressed in head and neck cancer, preliminary studies suggest that combining strategies that block both receptor families has a syne...Molecular therapeutics advance fight against brain cancer
...rs. He is currently investigating a variant of the epidermal growth factor receptor that is present in many primary glioblastomas to better understand the development of malignancy in the brain and how it relates to cancer cell division, survival, and movement....Activated signaling pathway may predict lung cancer patients' response to gefitinib
... Gefitinib, a cancer drug that interferes with the epidermal growth factor receptor (EGFR) pathway, is active in approximately 10% of NSCLC patients in whom standard therapy has failed. Although earlier studies have found that the expression of EGFR alone does not predict whether a patient will respond to gefi...Two-pronged attack targeting EGF receptor hinders cancer cell growth
Hitting the epidermal growth factor receptor (EGFR) both high and low with a combination of drugs for targeted cancer therapy curbs cancer cell growth more effectively than using the drugs each by themselves, researchers from the University of Wisconsin-Madison reported i...How wounds heal Clues from flies
...arked by rapid blood clotting and a recruitment of epidermal cells to the injury. When you remove a scab, you'r...erved the familiar blood clotting and spreading of epidermal cells to promote healing. Since this epidermal spreading resembles that seen during a well-studied d...Targeted therapy for lung cancer patients shows promise in extending lives
...th by blocking the action of a molecule called the epidermal growth factor receptor, or EGFR, a protein found in the cell membrane of some cells, but found at an abnormally high rate in cancer cells. The protein triggers cells to divide at an accelerated rate, which allows the abnormal cancer cells to grow and...When combining new oral anti-cancer agents with standard chemotherapy, timing may be crucial
...Gumerlock and his colleagues focused on a new oral epidermal growth factor receptor inhibitor known as erlotinib. Recently, several large clinical trials have compared standard chemotherapy alone to standard chemotherapy plus an oral EGFR inhibitor like erlotinib in the treatment of non-small cell lung cancer....Avastin-Tarceva combo provides 'one-two' punch against lung cancer
...ed tumor growth and spread. Erlotinib inhibits the epidermal growth factor receptor (EGFr), a key player in delivery of signals that prompt the runaway cell growth that characterizes cancers. Increased activity of the EGFr pathway, as well as increased number of tumor blood vessels resulting from VEGF express...RNAi delivery system crosses blood-brain barrier to target brain cancer
...) designed to interfere with the expression of the epidermal growth factor receptor, EGFR, a potent proponent o...to action when it binds a growth factor related to epidermal growth factor, a hormone growth factor that travels outside of cells in the blood. Activated EGFR no...JCI table of contents, 1 June 2004
...pidermis and dermis, and appears to be involved in epidermal differentiation and in protein-protein interactions within the skin. John McGrath and colleagues, from St. Thomas' Hospital in London, have now characterized the portions of EMC1 that are targeted by autoantibodies from the serum of lichen sclerosus ...The skinny on diagnosing skin disease
...pidermis and dermis, and appears to be involved in epidermal differentiation and in protein-protein interactions within the skin. John McGrath and colleagues, from St. Thomas' Hospital in London, have now characterized the portions of EMC1 that are targeted by autoantibodies from the serum of lichen sclerosus ...Gene expression profiling may predict head, neck cancer recurrence
...ted with the worst outcome; this subtype "shows an epidermal growth factor pathway activation signal, and that's potentially important because there are many new drugs in the clinic today that target that pathway," Perou said. Another subtype was associated with a "tobacco exposure signature," showing a high e...Other highlights in the May 19 JNCI
...ates are high, according to two new studies. Human epidermal growth factor receptor 2 (HER2) is overexpressed in the tumors of 20-30% of breast cancer patients and is associated with an increased risk of relapse and death in patients with early-stage breast cancer. In earlier clinical trials, adding trastuzuma...Second generation targeted antibodies - It's all in the binding
The overproduction, or 'overexpression', of the epidermal growth factor receptor (EGFR) is one of the most common aberrations in cancer, and subsequently agents that inhibit EGFR are among the most hotly-pursued potential products in the pharmaceutical industry. Now, just weeks after one of the first anti-E...JCI table of contents, February 2, 2004
...20963.pdf 2. Skin regeneration not isolated to epidermal stem cells The outermost layer of the skin the e...of keratinocytes. Skin grafts using human cultured epidermal cells have been successful in treating patients with severe skin wounds. The notion that the ability......of keratinocytes. Skin grafts using human cultured epidermal cells have been successful in treating patients wi...e notion that the ability to regenerate functional epidermal tissue is an exclusive property of epidermal stem cells is a general assumption in the stem cell bio...