Tag: "epidermal" at biology news
A popular Japanese plum, now available in the US, may help prevent the onset of cardiac disease
...entific community has previously reported that the epidermal
growth factor (EGF) receptor transactivation and subsequent extracellular signal-regulated kinase (ERK/MAP kinase) activation play central roles in signal transduction and gene expression of the AT1 receptor that leads to abnormal growth of vascular ...
Findings give insight into how colon cells transform into precancerous polyps
... Sciences. The signalling pathway involves the epidermal
growth factor receptor and the "ligands" that bind to it. The receptor sits across the cell surface, much like a satellite dish. The ligand fits into the receptor to transmit signals into the cell that prompt its growth. Scientists are focused on thi...
$13 million grant to fund research into molecular targets for colorectal cancer
...nd their leaders are: Project 1 will focus on the epidermal
growth factor receptor as a target for therapy in colorectal cancer (Coffey and Dr. Mace Rothenberg). This project will include a clinical trial using Iressa, an investigational EGF receptor-blocking agent. Project 2 will evaluate combinations of d...
Growth factor receptor signaling critical to intestinal tumor development, studies show
...mice, the researchers found that a molecule called epidermal
growth factor receptor (Egfr) is necessary for most intestinal tumors to form. Their work also suggests that a drug or genetic manipulation that inhibits the receptors chemical signaling machinery should help treat advanced colorectal cancers in huma...
Protein may be target for new cancer drugs
...ar communication. The scientists demonstrated that epidermal
growth factor receptor (EGFR) and Torso tyrosine kinase receptor remained switched on constantly in the mutant flies, because they depend on Hrs for inactivation. When they analyzed the Hrs protein, the scientists determined that it could bind specif...
Reining in cancer
...reast cancer. Another growth factor receptor the epidermal
growth factor receptor (EGFR) - is involved in an average of 70% of breast cancers. Iressa is designed to block the chemical pathway that the EGFR uses to promote uncontrolled cell division. The drug is currently being tested as a single agent in com...
UCSD biologists visualize protein gradient responsible for dividing embryo into nervous system, epidermis
...uent development into neural and distinct forms of epidermal
tissue. Their experiments provide final confirmati...Neural inducers also have an effect on the kind of epidermal
tissue, which forms next to the nervous system. Consistent with Turings model, some scientists beli...
Molecular insight into wound healing
...esponse to inflammation. Upon injury, specialized epidermal
cells called keratinocytes receive inflammatory signals that induce keratinocyte differentiation and migration to the site of injury, where they initiate the wound healing process. Dr. Wahli and colleagues have discovered that these inflammatory sign...
University of Pittsburgh researchers define precursors to cells that control the immune response
...urgh researchers have identified the precursors of epidermal
Langerhans cells (LCs), cells that reside in the s...the immune response, the cells differentiated into epidermal
LCs. When cultured in granulocyte macrophage-colony-stimulating factor, a protein that promotes the ...
Making new veins
...usly express the human HIF-1a gene specifically in epidermal
cells, and therefore always have high levels of active HIF-1 in their skin. Under normal oxygen conditions, these HIF-1a transgenic mice display such a marked increase in skin capillary formation that it is noticable to the naked eye (see figure). A...
Writing in Nature, scientists identify genes key to differentiating top from bottom in plant leaves
...ich is less densely packed with cells and has many epidermal
pores, is a plants main interface for the exchange of gases and water with the environment." In plants mutant in KANADI, Poethig and his colleagues found that the bottoms and tops of leaves were more or less identical. While the groups research sugg...
Disconnect between skin cells implicated in common skin cancer
... cell-cell junctions." The organization the skin's epidermal
layer depends on cell-cell connections formed by two types of intercellular structures: adherens junctions and desmosomes. The molecule alpha-catenin plays a role in adherens junctions and connects these junctions to a dynamic structural framework in...
Team identifies first drug therapy for rare, precancerous stomach illness
...basic research into the role in the stomach of the epidermal
growth factor receptor and one of the factors that... EGF receptor called C225. GFa is a cousin to the epidermal
growth factor whose discovery won Vanderbilt's Stanley Cohen, Ph.D., a Nobel Prize in Medicine. EGF ...
Skin and hair spring from the same stem cells, researchers find
...eration. But when a severe burn destroys the skin, epidermal
cells are found to emerge from any remaining hair ...cles of re-growth. The precise origin of those new epidermal
cells had never been established. Lavker and Suns theory that bulge stem cells were the source of ...
Hair follicles provide the stem cells for the skin's entire epidermis
...es. Instead, there is only one entity, an ultimate epidermal
stem cell that is capable of forming skin or hair....t certain types of skin cancer probably arise from epidermal
stem cells found in the bulge, because these cells and their progeny are located near the skin's sur...
Tailoring new cotton genes for industry
... answers to questions such as why only one in four epidermal
cells elongates," said Dr Orford. The project, which began in 1992, is funded by the Cotton Research and Development Corporation (CRDC), and aims to improve cotton fibre quality by genetic engineering. It is a challenge which means not only identifyi...
Study links two important cellular systems; increases prospects for new drugs for cancer, heart disease
...tuation in a system that links actin filaments and epidermal
growth factor effector proteins. That gave him an added advantage in seeing the importance of this latest discovery. "It is a different pathway from the one 10 years ago but it seems ...
Factor for acquiring skin barrier function identified
.... The skin is continuously regenerating, with new epidermal
cells emerging from anunderlying proliferative layer and migrating through several upper layers beforereaching the skin surface. When underlying cells reach the granular layer, theymake a specialized protein coat called the cornified envelope, which...
Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
...ells inculture, they found that a protein known as epidermal
growth factor receptor, orEGF-R, triggers the sequence of chemical steps. EGF-R is not common in theairways but another molecule, known as tumor necrosis factor alpha, stimulatesproduction of EGF-R in airway epithelial cells. Once present, EGF-R is a...
Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
... technology, ABX-EGF targets the receptor forhuman epidermal
growth factor (EGFr) which is overexpressed on many major humantumor types including renal, prostate, colorectal, head and neck, and breast. As reported in a paper titled, "Eradication of Established Tumors by a FullyHuman Monoclonal Antibody to the ...
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