Single isolated mouse skin cell can generate into variety of epidermal tissues
...ndicates a single skin stem cell can generate both epidermis and hair, even after propagation in the lab," Fuch...s compartment that have the capacity to regenerate epidermis in wounding, and to regenerate hair follicles in the normal hair cycle, but it hasn't been clear whe...Genuine stem cells found in skin might treat hair loss, wounds
...ncy required to differentiate into all lineages of epidermis and hair," said Elaine Fuchs, cell biologist at Ro... follicle with each hair cycle and to generate new epidermis during wound repair, the team explained. Using new avenues to probe the cellular architecture of ste...Skin stem cells give hairless mice hair
...f stem cells -- some of which could repopulate the epidermis and others that could produce hair follicles. "The second major question was whether these cells were capable of undergoing self-renewal. And of particular interest to clinicians was whether they could undergo division in a lab dish and still have t...Possible new cure for psoriasis
...inhibitors can normalise the increased tendency of epidermis cells (keratinocytes) to divide, which is the caus... In this incurable disease the regeneration of the epidermis is speeded up enormously: whereas it normally renews itself in just under four weeks, this period is...How wounds heal Clues from flies
..., but epidermal spreading to regenerate the intact epidermis was either blocked or defective. In contrast, larvae with defects in a gene required for the generation of crystal cells--a type of blood cell implicated in processes linked to scab formation--could not properly form scabs. In these scabless wounds, ...From lung to gut the Wnt signaling pathway transforms cell fate
...pment. Wnts also control cell fate in cells of the epidermis and hair follicle. "These results show that hyperactive Wnt signaling in lung progenitor cells can induce a dramatic shift in lineage commitment and the generation of intestinal cell types," write the authors. Understanding the mechanism by which the...JCI table of contents, 1 June 2004
...t in the disease. ECM1 is a protein present in the epidermis and dermis, and appears to be involved in epidermal differentiation and in protein-protein interactions within the skin. John McGrath and colleagues, from St. Thomas' Hospital in London, have now characterized the portions of EMC1 that are targeted b...The skinny on diagnosing skin disease
...t in the disease. ECM1 is a protein present in the epidermis and dermis, and appears to be involved in epidermal differentiation and in protein-protein interactions within the skin. John McGrath and colleagues, from St. Thomas' Hospital in London, have now characterized the portions of EMC1 that are targeted b...JCI table of contents, February 2, 2004
...l stem cells The outermost layer of the skin the epidermis is a rapidly renewing tissue and relies on the re...ogenitor cells, could also form a fully stratified epidermis under appropriate microenvironmental conditions. The authors also demonstrated that the regenerative...Skin regeneration not isolated to epidermal stem cells
The outermost layer of the skin the epidermis is a rapidly renewing tissue and relies on the re...ogenitor cells, could also form a fully stratified epidermis under appropriate microenvironmental conditions. The authors also demonstrated that the regenerative...New method of identifying and isolating stem cells developed
...e mysterious cells are able to replenish both skin epidermis and hair, and what nutrients may help stem cells p...pplications, such as improved regeneration of skin epidermis for burn victims and new understanding of what prompts skin stem cells to grow new hair. "And this ...How tea works against skin cancer
...hat polyphenols inhibited both targets compared to epidermis from mice in the control group. Working with cultured human and mouse epidermal cells, they found a similar pattern. The researchers suggested that polyphenols in tea can interfere with signaling pathways inside cells that may "order" cells to divid...Splitting hairs: GATA-3 function in hair follicle development
...l as their whiskers appeared, the remainder of the epidermis of these pharmacologically rescued GATA-3-null mice appeared to function properly. When Dr. Fuchs and colleagues grafted dorsal skin from pharmacologically rescued GATA-3-null mice onto GATA-3-normal mice, and thereby allowed the hair follicles more...New target for skin cancer confirmed
... sun for a few minutes, the activity of JNK in the epidermis rises," said Dong. "If you go out for a few minutes, JNK activity doesn't stay elevated. But it looks as though if a person gets too much sun exposure, JNK activity becomes permanently elevated and cancers develop. This study indicates that some form...JCI table of contents, 16 June 2003
... transgenic mice overexpressing viral IL-10 in the epidermis AUTHOR CONTACT: Richard D. Granstein Cornell Univesity, Weill Medical College, New York, New York, USA. Phone: 212-746-7274 Fax: 212-746-8656 E-mail: rdgranst@med.cornell.edu View the PDF of this article at: https://www.the-jci.org/press/15722.pd...Green tea linked to skin cell rejuvenation
...surprised." The skin consists of three layers: the epidermis (outer layer), dermis (mid-layer) and hypodermis (...CG, the old cells found in the upper layers of the epidermis appear to start dividing again," Dr. Hsu said. "They make DNA and produce more energy. They are reac...Laser micro-scalpel yields biological insights into tissue dynamics
...ssue involved in knitting the closure; the lateral epidermis is the tissue layer that ultimately forms the flys...e-string along the boundary contracts, the lateral epidermis cells are stretched, and the two sheets of lateral epidermis along those purse-strings are zipped to...Rockefeller scientists identify 'natural' proteins that push stem cells to produce hair, not skin
...lly programmed to develop into either hair or skin epidermis is emerging with mouse embryos as models for human... cells at the body surface are forming either skin epidermis or hair, other stem cells in the embryo are differentiating in a similar way, migrating away from th...... lackanchoring fibrils that ensure adhesion of the epidermis to the dermis anddevelop subepidermal blisters in response to minor mechanical stress. Thecurrent lack of treatment is an impetus to develop gene therapy strategiesthat will restore anchoring fibrils. Paul Khavari and colleagues havefocused on fibrob......und in all epithelia including the hair, nails and epidermis of humans, as well as the fur, feathers and hooves of animals. Of the nearly thirty keratin genes expressed in hair follicles, Dr. Coulombe and colleagues found that a deficiency in just one keratin 17 causes temporary baldness in mice. Dr. Coulom...