Safety of isoflavones in dietary supplements targeted by Illinois initiative
... at the mechanisms at work between isoflavones and estrogen receptors." While most food scientists stress ...influence on the progression of breast cancer from estrogen dependent to estrogen independent tumors. Paul S. Cooke will lead a project focusing on adipo...Select research highlights from current AACR journals
...evels. The inhibitor drugs act by interfering with estrogen synthesis and depleting estrogen concentrations in the blood, according to the study by Goss et al., conducted at the University of T...APS awards more than $140,000 to minority students of physiology
...her lab suggest that uranium acts like the hormone estrogen by eliciting estrogen-sensitive responses in uterine tissue. She plans to investigate the mechanisms through which uranium elicits these responses. "This program has aimed to make careers in physiology accessible to minority students since the 60's ...OHSU-VAMC study sheds light on estrogen's benefit for MS
...he first report that this single, benign compound estrogen can increase regulatory cells," said study co-aut...ese new estrogen-like drugs." The study found that estrogen treatment simulates pregnancy in increasing T cell levels. It also demonstrated that estrogen boosts...Ovarian cancer sheds tumor suppression with loss of estrogen receptor
An important receptor for estrogen in ovarian cells has been shown to suppress tumor ..., however, the number of these receptors--known as estrogen receptor beta (ER beta)--diminishes, encouraging these tumors to advance toward malignancy and metas...Genetic mutation linked to more aggressive breast cancer found more often in African-Americans
...characteristics on histopathology, such as lacking estrogen receptors. Beth A. Jones, Ph.D., M.P.H., from Yale University School of Medicine and her colleagues studied the breast tumors of 145 African-American and 177 white women to further characterize the pattern of alterations of genes known to relate to t...UCI study reveals gene linked to breast cancer can suppress tumors
... The work also provides further evidence about how estrogen helps activate a disease that afflicts thousands o...ancer cells. The gene accomplishes this by keeping estrogen and growth factor molecules from sending chemical messages through specific signaling pathways on th...When male fish hum, females swim in, thanks to hormones, adaptable hearing
...eurobiology and behavior. They also identified the estrogen receptor in the female inner ear where the enhancement begins. "This was especially important since estrogen receptors are also present in the human inner ear but no one know why they might be there. Our study...Hormone helps fish to mate, may affect human hearing
... Bass's colleagues at Cornell, also identified the estrogen receptor in the female inner ear where the enhance...orlano notes: "This was especially important since estrogen receptors are also present in the human inner ear but no one knows why they might be there. Our stud...Animal research suggests plant estrogens in soy do not increase breast cancer risk
... therapy. The most common form of hormone therapy, estrogen plus a progestin, has been shown to increase risk ...t estrogens are thousands of times weaker than the estrogen produced by the body, but may be present in much higher concentrations in the blood. Evidence about ...Donaghue Women's Health Investigator Program awards grants to three at Yale
...ating these women. van Dyck's research focuses on estrogen and serotonin receptors in menopausal women with depression. His study will examine the serotonin-2A receptor in the brain, especially in the prefrontal cortex. This receptor appears to be involved in the regulation of mood and the actions of antid...Other highlights in the June 16 JNCI
...shows that common mutations in genes that regulate estrogen metabolism are not associated with breast cancer r...tide polymorphisms or SNPs, in genes that regulate estrogen metabolism. They found SNPs in two genes that affected estrogen metabolism. However, there was no as...Study investigates breast cancer resistance to tamoxifen and possible way to reverse it
...se with tumors that express the drug's target, the estrogen receptor (ER)--only 40% to 50% actually benefit. S...ound that, in these cells, tamoxifen acted like an estrogen agonist and stimulated tumor growth. However, when the breast cancer cells were treated with the rec...Scientists characterize new breast tumor subtypes with poor clinical outcomes
...at characterize a biologically distinct subtype of estrogen receptor negative breast tumor. Because this tumor...ognized for some time that there were two types of estrogen receptor negative tumors, those with receptors for the HER2 protein and those without it. "But, it w...Synthetic hormone used in contraceptives and HRT produces negative effects in monkey studies
...eived one week each of three different treatments: estrogen only, estrogen plus natural progesterone, and estrogen plus MPA. Monkeys displayed significantly more a...Gene expression ratio identifies risk of recurrence in breast cancer patients receiving tamoxifen
..., which blocks the interaction between the hormone estrogen and its receptor protein, is used to treat breast cancers that express the estrogen receptor. However, only two thirds of these patients have a prolonged response to the drug. "Until n...Molecular marker predicts success of breast cancer treatment
... breast cancer. It works by blocking the action of estrogen on breast cancer cells. Estrogen directs the growth of normal breast cells, but can also stimulate the abnormal and unregulated cell growth associated with breast cancer. Unfortunately, nearly 40% of breast cancer patients fail to respond to tamoxife...Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
...treatment can be mediated by a modification of the estrogen receptor. These results enhance the understanding ...e-quarters of all breast cancers are stimulated by estrogen acting at functional estrogen receptors (ER+), they are most often treated with anti-estrogen compou...Other Highlights in the June 2 JNCI
... mechanisms that increase tumor proliferation, but estrogen may also play a role in the regulation of angiogen...Research in Bethesda, Md., and colleagues show how estrogen may act as an angiogenic switch and allow progression of breast carcinoma. Contact: Susan Johnson, N......lga Weinberg will spend next year at UCLA studying estrogen receptors and growth factor receptors in non-small... study will test the hypothesis that activation of estrogen and associated growth factor receptors enhances growth of NSCLC, possibly offering new therapeutic t...