Long-Standing Puzzle Of Immune System Is Solved By UCSF Researchers
...sease. Immunologists previously unearthed evidence indicating that immunecells can even activate mechanisms for producing additional mutations, aprocess dubbed hypermutation. But until now, none of the key molecularplayers used by immune cells to generate these mutations had beenidentified. ...Candidate Regulator Of The Temporal Component Of Neurotransmitter Release Identified
...the groups of Betz and Augustine now have found evidence that the speed of transmitter release itself may be controlled, somewhat ironically, by the evolutionarily highly conserved general fusion protein NSF (for N-methylmaleimide sensitive fusion protein). The groups have synthesized NSF-fragm...Scientists Invent Faster Gene Function Identification System
...thin 24 hours after they hatch. Andthere is strong evidence of genetic similarities between zebrafish and othervertebrates, including humans, Wagner says. "Scientists are learning a lot by the identification of gene sequences,but without information on what those genes do, sequence identification is ...... the first time, scientists have publishedresearch evidence that recombinant protein therapy can create new blood vesselsto increase blood supply to the human heart. The report from German scientistsappears in today's Circulation: Journal of the American Heart Association. FGF-I, a human growth fact...Biologists Map First Gene For Age-Related Hearing Loss In Mice
...a single stretch of Chromosome 10,that was further evidence of the location of the Ahl gene. The researchers used two different techniques to documenthearing loss in the mice. The first is called ABR for auditory-evoked brainstem response which measures the reception andtransmission of nerve signals in the br...Study Links Viruses And Vascular Diseases
...dibilityproblem -- there has never been any direct evidence that viruses can injure humanvessels. Now, thanks to a surprising discovery at Washington University Schoolof Medicine in St. Louis, there is a new reason to reconsider the idea. In arecent issue of Nature Medicine, the researchers reported that a vi...Women Can Inherit Drinking Problem Too, Study Finds
...rnal Psychological Medicine. While there is ample evidence for an important genetic influence on alcoholismrisk in men, the tie between genetics and alcoholism in women has beenuncertain, said the paper's lead author, Andrew Heath, Ph.D., a professor ofpsychiatry at Washington University. The study sought t...Will Global Change Increase Fire Activity In The Mediterranean Basin?
...14-18, 1998. The Science Scientists will provide evidence that several components of global change,namely increased air temperature, reduced precipitation and land use changeshave the potential to worsen wildfires in this region and may already be doingso. Dr. M. De Lus and coworkers (University of Alacan...Will The Loss Of Biodiversity Alter Ecosystem Functioning?
...ity of Minnesota, USA,will review the experimental evidence available on the ecosystem consequences ofa biodiv...ystem function than species number. Experimental evidence also suggests that diversity provides an insuranceagainst extreme events in some cases. Dr. M. Diem...Change In HIV May Precipitate AIDS
...ture Medicine paper, theresearchers present strong evidence that it is a change in the virus itself thatleads to irreparable damage to the immune system. Dr. Margolis and his coworkers showed that, after being infected withT-tropic viruses, the response of the tonsil blocks to immunological challengei...New Sickle-Clawed Fossil From Madagascar Links Birds And Dinosaurs
A new raven-sized fossil bird, showing clear evidence of the closerelationship between theropod dinosaur... The forearm bone of Rahona is long and shows evidence of well-developedfeathers, indicating it was a capable flyer. But unlike most birds, Rahona alsohad...Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
...ins of two children with Canavan disease, based on evidence of nerve myelination and on behavioral studies. They have gained federal Food and Drug Administration approval, Dr. Freese notes, to expand the work into a larger Phase 1 clinical trial. To date, the Jefferson team plans to treat four Canavan disease......odium per day. This recommendation is based on the evidence of anassociation between dietary sodium intake and blood pressure derived from asubstantial number of epidemiological observations and clinical trials of saltrestriction. Reduced sodium intake, however, should be only one component of a comprehensi...Lights, Camera ... Reaction: Charting The Biological Effects Of Light InBillionths Of A Second
...urnal Science, provides thefirst direct structural evidence of how light can be converted into chemicalenergy -- the initial stage of processes as different, and as fundamental, asphotosynthesis and vision. It also may suggest a powerful new mechanism for thedevelopment of optical computers. The ability to re......is of special interest because it provides further evidence in support of thetheory that birds evolved from di...d avery advanced characteristic of birds - to find evidence of this characteristicin such a primitive bird is surprising and indicates that this ability actuall...Gene-Reading Problem Linked To Lou Gehrig's Disease
...hesporadic form. The Hopkins team first found evidence of the mutation in a patient who hadthe inheritedform of ALS and unusually reduced levels of EAAT2. The problem, the researchersdiscovered,was an error in the way the patient's nerve cells were translating the DNA codefor EAAT2 intoRNA. Cells u......"So far our study appears to provide the strongest evidence that highertriglyceride levels are related to increased risk of ischemic heart disease inmen independent of other major risk factors such as total cholesterol and HDL(high-density lipoprotein) cholesterol," says Jorgen Jeppesen, M.D., of theEpidemiol...New Guidelines To Improve Public Understanding
...ut keep reminding people that it's the totality of evidence as it unfolds that warrants their attention." In addition to publication in JNCI (2/4/98), the guidelines were reported in the Journal of the American Medical Association (JAMA, 2/11/98). Reprints of the JNCI article and JAMA report and a booklet ve...Peptides Implicated In Body's Response To Pain
...nses to pain, providing scientists with compelling evidence of thechemical's role in transmission of pain messages. Together with glutamate, substance P is known to stimulate pain receptors, butits precise action is less clear and its function complex. In the currentstudy, release of substance P and neurokin...Chromosomal Abnormalities Key For Prediting Leukemia Outcome
...enetics. “This study provides stronger evidence for the correlation betweencure and a patient’s cytogenetics, and between cytogenetics, survival,and the treatment that patients receive,” said Clara Bloomfield, directorof the Ohio State University's Comprehensive Cancer Center and William...