JCI table of contents, 2 August, 2004
...ed B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease AUTHOR CONTACT: Klaus Ley University of Virginia Health Science Center, Charlottesville, VA 22908, USA Phone: 434-243-9966; Fax: 434-924-2828; E-mail: klausley@virginia.edu View the PDF of this article at...Research finds lawn chemicals raise cancer risk in Scottish terriers
...se this study shows that exposure to the chemicals exacerbates a genetic predisposition in Scotties towards developing TCC, it's likely that only a segment of the human population would be in similar danger. "But we still need to find out who those individuals with the same predisposition are. Until we do, we wo...Link between alcohol consumption and muscle damage in females
...is also some evidence to suggest that malnutrition exacerbates the effects of alcohol on muscle, the mechanisms responsible for myopathy remain elusive. Some studies suggest that acetaldehyde (a toxic intermediate compound formed by the action of alcohol dehydrogenase enzyme during the metabolism of alcohol), ra...When heme attacks: After trauma, the molecule that makes life possible rampages
...eme floods the spaces between and inside cells and exacerbates the damage. It does so by shutting down an important cell membrane channel, an action that kills neurons and constricts blood vessels. While investigating this process, the researchers also determined that a chemical called NS1619 restores the funct...Common gene variant increases risk of atherosclerosis
...y klotho increases the risk of atherosclerosis, or exacerbates the effects of smoking, is still unknown. The klotho gene carries the blueprint for a protein that seems related to enzymes known as beta-glycosidases, but no specific target for the klotho protein has been identified. The KL-VS gene results in two c...How postnatal experience influences brain development and brain function
... properly, than in typical brains. Pathology often exacerbates the mechanisms the brain uses to adapt to the demands of the world, Greenough said in today's session on "The Effects of Early Experience on Brain and Brain Development." "When the circumstances are abnormal, you get abnormal results," he said. "Fro...Collaboration advances potential therapy for autoimmune diseases
...ron, a protein that when overproduced triggers and exacerbates various autoimmune conditions. This work is a major step toward creating a much-improved treatment for certain autoimmune diseases. Until recently, most treatments employed antibodies derived from mice, which were effective but could be used only o......a to flourish and overwhelm the lungs." While HIV exacerbates many diseases, TB poses a particularly dangerous problem because it is so widespread. World health professionals predict that more than one-quarter of the AIDS patients in the world will die from TB this year. Offering a light at the end of the tunne...Oncogene spawns further mutation in breast cancer study
...s have demonstrated that, in living creatures, MYC exacerbates tumor growth in breast cancer by inducing a secondary pathway involving ras mutations. Synergy is a nice trait to find among human endeavors, said Chodosh, But synergy among oncogenes makes my work a little more complex. According to Chodosh, cancer......ffects a different part of the brain in a way that exacerbates the effects of Parkinson's. Researchers at the University of California, Santa Cruz, evaluated the effects of low-level exposure to manganese using rats with a condition that mimics pre-Parkinsonism, an early stage of the disease in which no symptoms...Study: fertilized lakes less stable than previously thought
... to earth in rain, said Cottingham. Urbanization exacerbates the problem as well. When rain falls on cities, it typically flows directly from city streets and storm sewers into lakes and rivers, bypassing the natural filtering process that occurs when rain percolates through soil. While this study only analy...Acid-loving microbe may be a key to mine pollution
...takes place all over the Earth's crust, but mining exacerbates the problem by exposing metal to air and water," she says. Banfield's group has been working at the Iron Mountain Mine for nearly five years, and has gained significant insight into an environment that is extremely hostile to any form of life, an env...Large air pollution center established at NYU School of Medicine
...llness. Other studies will determine whether ozone exacerbates the effects of particulate matter in asthmatics, and whether there are so-called biomarkers, like inflammatory chemicals in the blood, that can serve as indicators of exposure. "Overall, we anticipate that our studies will help establish that ...UI study suggests genetics and gender affect human response to endotoxin
...dust, airpollution and household dust -- causes or exacerbates asthma and other lungproblems in some, but not all, people with respiratory conditions. A recentUniversity of Iowa Health Care study provides evidence that when it comes tohealthy individuals, pulmonary responses to endotoxin can also differ markedly...Nearly half of Earth's land has been transformed by humans; 50 'dead zones' found in oceans
...dings. "The dramatic rise in our populationsimply exacerbates the problems," Lubchenco stated, noting that as of July 17,1999, there are reportedly six billion people on Earth, a doubling in less than40 years. Lubchenco did see hopeful signs in the increasing number of people who areconcerned about the environ..."A Little Bit Here" And "A Little Bit There" Can Add Up To A Big Problem
...s and reducing concrete andasphalt pavement, which exacerbates runoff. In order to reach several different audiences, the research is available inthree formats: a technical paper to be published in the August, 1998 issue ofESA's journal Ecological Applications (available now to journalists); a 20-pagereport wri...