Study reveals first genetic step necessary for prostate cancer growth
...genes in the epithelial cells of the prostate. Our experimental approach allows us to closely mimic what happens in man and gives us a glimpse into the natural history of the disease that we haven't had before." Greenberg developed a widely used genetically engineered strain of mice that develops prostate cancer ...New imaging technology at Joslin shown to detect early signs of type 1 diabetes
...anges, during the development of disease and after experimental or therapeutic interventions aimed at stopping its progression. Further, they point out that the technique already has been used safely and effectively by the MGH group in human clinical trials to detect the spread of prostate cancer to the lymph nod...Disease diagnosis, drug development focus of UH prof's biochip research
...leading academic and industrial researchers in the experimental and theoretical nanosciences, to showcase the role of computational science underpinning and enabling innovations, and to consider specific applications of nanotechnology. Conference proceedings will be published in the international journal, Molecu...NIGMS funds Center for Quantitative Biology
...ex biological systems based on large quantities of experimental data, a systems biology approach. To help spur fur...l research. By bringing together computational and experimental scientists, the center promises to accelerate the pace of scientific discovery and serve as a model ...APS awards more than $140,000 to minority students of physiology
...t State University Through the use of an in vitro experimental model, Mr. Garcia is studying the effects of excess oxygen on electrical signaling in the central nervous system (CNS). This research will help elucidate the neural mechanism that causes CNS oxygen toxicity. CNS oxygen toxicity is a potential healt...Washington University in St. Louis plays key role in sequencing moss genome
...be adapted for use in contemporary crops. Unique experimental features include few and simple cell and tissue types, ease in growing and undergoing sophisticated genetic manipulation including the capacity of this organism to integrate transforming DNA by homologous recombination at frequencies higher than that...Columbia, Stony Brook, Guidant to develop biological pacemaker based on gene & cell therapies
... by an ionic current that stimulates the hearts of experimental animals to generate a heartbeat similar to that of the heart's natural pacemaker, the sinoatrial node. ...Protein fishing in America: The movie
...d real-time interactions of single proteins. Their experimental evidence, reported Thursday at the 228th national meeting of the American Chemical Society, supports the fly-fishing theory of protein communication. "In the past five years, the field of protein-protein interaction dynamics has exploded," said Lu, ...OHSU-VAMC study sheds light on estrogen's benefit for MS
...rotecting mice against a model for human MS called experimental autoimmune encephalomyelitis (EAE). Autoimmune disease has been associated with a deficiency of FoxP3, whose expression is a reliable indicator of the regulatory T cells' function and development. "This is the first report that this single, benign c...Marathoning mice could have Olympian effects on obesity
...pt, Evans and his team treated normal mice with an experimental drug called GW501516 that activates PPAR-delta. These mice also expressed genes for slow-twitch muscles and gained less weight when given a high-fat diet. This drug is now in the earliest stages of being tested on people for its effects on obesity an...Millennia still mean early days for newly identified sex chromosome
...chromosomes begin to form in the first place. Some experimental data from young sex chromosome systems in plants and insects suggest that there are common themes underlying the formation of sex chromosomes. However, to determine if these mechanisms are generally applicable, more examples, particularly from other ...Genetically-engineered 'marathon mouse' keeps on running
...ransformation, the researchers gave normal mice an experimental drug, called GW501516, that activates the protein. The drug is being developed by GlaxoSmithKline to treat people with lipid metabolism disorders. Evans and his colleagues found that treatment with the drug produced muscle and metabolic benefits simi...PCB breakdown in rivers depends on sediment-specific bacteria, find Carnegie Mellon U. scientists
...e-by-side comparison of populations using the same experimental approaches under identical conditions. Despite 30 years of scientific investigation and search for remediation approaches, the contamination of waterways with PCBs remains a pressing environmental challenge. A mixture of 209 related chemicals, PCB...Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
...erapy on myocardial structure and function in this experimental model supports the potential for stem cell-based reparative treatment of myocardial infarction. By regenerating diseased myocardium and promoting cardiac repair, embryonic stem cells provide a unique therapeutic modality that has the potential to red...Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
...tary liver disorder died after participating in an experimental gene therapy trial in 1999. In another case, two young boys who received gene therapy for the severe immunodeficiency disorder known as "bubble boy disease" developed leukemia-like symptoms 30 months after treatment. In this case, the viral vector in...Jefferson Lab detector technology aids development of cystic fibrosis therapy
...s produced when the Lab's electron beam strikes an experimental target. In medical imaging, photons are emitted by a radioactively labeled molecule that has attached to other molecules in the body. This technology allows doctors to image cellular function in areas of interest and has already proved its usefulness...Brain's reward circuitry revealed in procrastinating primates
...y a sustained low rate of errors in performing the experimental task, irrespective of how distant the reward might be," said Richmond. "This was conspicuously out-of-character for these animals. Like people, they tend to procrastinate when they know they will have to do more work before getting a reward." To ma...Excess levels of nitrogen, phosphorus linked to deformed frogs
...He and Johnson poured phosphorus and nitrogen into experimental ponds in Wisconsin and will see if they get a high...the parasites, and deformed frogs when compared to experimental ponds without those nutrients. Johnson and Chase's finding adds to the growing list of wron...Evolvability could be a driving force in drug resistance
... evolvability would help explain a growing body of experimental results including the evolution of drug resistance in bacteria, the fact that some immune system cells mutate much more rapidly than other cells in our bodies, as well as why some bacteria and higher-order organisms have a tendency to transpose or sw...Parasitic cowbirds thrive with a less ruthless strategy than cuckoos
... of the nests were used as sources of eggs for the experimental nests, as controls, or contained cowbird eggs that...average clutch size of five eggs. "This was a very experimental study, combining some specific predictions from the literature with a purely experimental approach,"...