UCSD researchers are first to demonstrate molecular link between inflammation and cancer
...ch is commonly used to induce colorectal cancer in experimental animals. The second compound was a pro-inflammatory irritant called dextran sulfate sodium salt (DSS), that eroded the intestinal-tract epithelial cells, allowing the entrance of enteric bacteria, with resulting inflammation generated by the body to...Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find
...ng and Dementia. "Our data are among the strongest experimental evidence to support the amyloid cascade hypothesis. We've demonstrated in the lab that removing plaques from the brain can indeed lead to a total clearance of tangle pathology." LaFerla's group is now investigating if combined therapy — one aime...Depression traced to overactive brain circuit
...eals where the brain is active during a particular experimental condition. They randomly gave 27 unmedicated depressed patients-in-remission and 19 controls either pills containing seven essential amino acids, such as lysine and valine, or identical-looking placebo pills. Subjects received either the active pi...Protein vaccine fully protects mice from lethal aerosol challenge with ricin toxin
Scientists have developed an experimental vaccine against ricin, a potential biological threat agent, which fully protected mice from aerosol challenge with lethal doses of the toxin. The study was performed at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). Ricin...JCI table of contents, 2 August, 2004
... ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia AUTHOR CONTACT: Jorge A. Bezerra Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave. Cincinnati, Ohio 45229, USA Phone: 513-636-3008; Fax: 513-636-5581. E-mail: jorge.bezerra@cchmc.org View the PDF of this article at: ...Lehmann lovegrass won't succumb to fire
...es against other options, Geiger set up fifty-four experimental 2.5 acre (one hectare) plots at various locations on the Fort Huachuca Military Reservation near Sierra Vista, Ariz. One-third of the plots contained only native grasses, one-third only non-native grasses, and one-third had a mix. She then as...Iron can have negative side effects on people with kidney disease
...iety of Nephrology, just released findings from an experimental study revealing that intravenous iron therapy admi...ation of the issues raised by the findings of this experimental paper." The study provides support for the concept that parenteral iron formulations are potentially...New glycan arrays discover autoimmunogenic activities of SARS-CoV: concern over monkey vaccine
...oimmunogenic activity." Wang and Lu note that the experimental approaches developed in their research are likely ...rresponding complex carbohydrates. With this novel experimental strategy, they characterized SARS-CoV neutralization antibodies and detected significant levels of I...Firefly compound lights up 'protein dance' in living animals
...which pair of fragments worked best. In a line of experimental mice, scientists genetically fused one member of the best pair of luciferase fragments onto the protein targeted by rapamycin, attaching the luciferase fragment to the specific portion of the protein where rapamycin establishes its bond. They attach...Proteomic research centers target bioterrorism agents, infectious diseases
...ore proteomics information, including source data, experimental protocols, and novel technologies supplied by six Proteomics Research Centers. Free public access to the system and stored information will be provided through a website. Direct queries and client applications will be enabled through VBI's PathPort/T...Study reveals surprising 'remodeling' property of gene regulation process
...n to occur." The study used the yeast genome as an experimental model to determine if chromosomal remodeling actually occurred. "The yeast genome is very simple compared to the human genome, but yeast are quite responsive to their environment," Lieb said. By varying the food source given to the yeast, the authors......lizes in force impact to the lower extremities, an experimental modeling technique in kinesiology that can be appl... system. Musculoskeletal dynamics "Integrating experimental and modeling approaches of studying human movement allows us to understand how the nervous system ta...Researchers find that color perception is not innate, but acquired after birth
Rearing experimental animals under special illumination, researchers have found new evidence that early visual experience is indispensable for the development of normal color perception. The wavelength composition of the light reflected from an object changes considerabl...Long-term heart damage may result from constant confrontation and defeat
...us was present or shortly thereafter. In addition, experimental stress has produced a considerable increase in heart rate. Long-term effects of social challenges on a number of physiological and behavioral parameters have also been reported, mainly involving the daily rhythms of heart rate, body temperature...Tips from the Journals of the American Society for Microbiology
...ease and Potential Biowarfare Agent A new experimental vaccine may protect against brucellosis in humans say researchers from Washington, DC and Silver Spring, Maryland. Their findings appear in the July 2004 issue of the journal Infection and Immunity. Brucella abortus, B. melitensis, and B. suis, ...JCI Table of Contents, 15 July 2004
...his activity. TITLE: Apolipoprotein A-IV inhibits experimental colitis AUTHOR CONTACT: Theodore J. Kalogeris Lo...-- IDO Says Don't to Asthma TITLE: Inhibition of experimental asthma by indoleamine 2,3-dioxygenase AUTHOR CONTACT: Eyal Raz, University of California, San Diego...Sequential signals choreograph embryonic tubule formation
...own in collagen gels and stimulated with HGF. This experimental protocol results in the formation of branching tubules that resemble the development of tubules in many organs in vivo and allows for examination of molecular events that occur during tubulogenesis. "We found that downstream targets of HGF coordinate...Triple-vaccine strategy stimulates strong HIV-specific immune response in monkeys
...recedented levels of CD8+ T cells in monkeys." The experimental vaccines developed by Ertl and her colleagues take advantage of sophisticated bioengineering technologies and the special characteristics of a class of viruses called adenoviruses to create a series of three vaccines that, when given in sequence, bui...Lack of immune system protein prevents lupus-like condition in mice
... system functions were still largely intact in the experimental mice that lacked SAP," says Stanford Peng, M.D., Ph.D., assistant professor of medicine in rheumatology and of pathology and immunology and lead investigator for the study. "Other immune system proteins are potential targets for new autoimmune diseas...Milk consumption and calcium intake associated with lower colorectal cancer risk
...ors. "These data, in combination with the previous experimental studies documenting a salutary effect of calcium supplementation on colonic epithelial cell turnover and colorectal adenoma recurrence, support the concept that moderate milk and calcium intake reduces the risk of colorectal cancer," the authors writ...