Newly Discovered Gene Halts Cell Division and May Have Cancer Link
... suspicion -- the cell line had low levels of MAD2 expression compared to control cells that were resistant to both drugs. The drugs may be especially effective in the treatment of tumors with a defective checkpoint, Dr. Benezra says. That's because the drugs, coupled with the faulty checkpoint, so completely ...Two Long-sought Diabetes Gene Found
...f. Both were known to be active in regulating gene expression in the liver, kidney and intestine. "This surprisi...unctions of HNF-4-alpha (MODY1) is to regulate the expression of HNF-1-alpha (MODY3). HNF-1-alpha and HNF-4-alpha are members of a regulatory pathway first identi...New Finding Suggests "HATs" Are Key To Gene Activation Puzzle
...ones, the proteins thatcontrol DNA replication and expression cannot access the DNA to do their jobs. It's the job of enzymes known as HATs, orhistoneacetyltransferases, to unwind chromatin. Now, using a unique assay developed at Rochester, Allis and his colleagues have located a new HAT that is part of at...New Study Shows Steps Leading To Colon Cancer
...goes into the cell nucleus and helps regulate gene expression or, in other words, turns genes on and off." In normal embryonic development, by switching genes on and off, the protein tells cells which tissues they should make and directs, for example, development of arms and legs, Peifer said. The process o...... for the first time havesucceeded inpreventing the expression of genes that make bacteria resistant to two widelyused antibiotics -- chloramphenicol and ampicillin -- thus restoring thebacteria's sensitivity to the antibiotics in laboratory cultures. If successfulin animal and human studies, the general method...Evolution Re-Sculpted Animal Limbs By Genetic Switches Once Thought Too Drastic For Survival
... it, in which scientists study thepatterns of gene expression in embryos to peer backward in time. In the past f...gy that mirrored what washappening with respect to expression of the gene. They weren't finding that ininsects, but in crustaceans we show a very striking example...Newly Discovered Human Protein Provides Important Target For Cancer Therapy
...ould explain theregulation of telomerase activity: expression of the genes does not correlatewith observed level...n mortal normal cells. "This suggeststhat hEST2 expression might underlie the activation of telomerase that occursduring cellular immortalization," Dr. Meyerso...Early Menarche Puts Young Girls In Peril
... shape and appearance of their bodies as a primary expression of their individual identity," Brumberg writes. Th...educes them into thinking that the body and sexual expression are their most important projects." The 250-page book begins with a review of the new biological ti...Further Proof That An Altered Rb-2/p130 Gene Leads To Lung Cancer
...cer Research .. The researchers monitored the expression of the Rb2 gene, which is a normal gene and is expressed in all tissues, in normal cells. They showed that two Rb-2/130 proteins, pRb-2/130 and p107 , are ubiquitous throughout the body’s tissues and play vital roles in cel...Genetics Debate Suffers From Misinterpretation, Scholar Says
...ween a gene pool of a particularpopulation and the expression of a certain trait under certain environmentalconditions, Hirsch said. "It is not a measure of so-called nature-nurtureratio -- what proportions of human intelligence are due to nature and tonurture -- though it is widely misinterpreted as such. Heri...Presence Of Protein Extends Life; Potential Aging Mechanism Found
...rains to short doses of nonlethal warmth, inducing expression ofa protein dubbed hsp70. Flies bred to contain ex...at treatment. Only a brief, low level of genetic expression was required to obtain along-term improvement in survival of the flies, said Tatar, now an assistant......cteristics of factors capable of regulating the expression and/or function of other genes. Whether these other genes that are under control of the APECED gene product are specifically expressed in the thymus and in other immunological tissues is still disputable. It is however likely that the APE...Pitt Researchers Construct Novel Delivery System For Gene Therapy Of Liver Disorders
...ose was 50 mg of DNA. Although the highest expression of the gene was found in the liver, geneactivity a...ncorporated in RCRsrestored the high level of gene expression in the liver. Long-term expression of genes is necessary for successful gene therapy. "By ad...Researchers Discover New Genetic Risk For Alzheimer's Disease
...ofAlzheimer's disease. It caused a higher level of expression of APOE, regardlessof whether the APOE gene was th... "So we believe that the higher levels of APOE expression arecontributing to an increase in the risk for Alzheimer's disease," Goateexplained. "And we believe......r Center in Maryland,will discuss her work on gene expression in mice. University of Iowa researcher Val Sheffield will speak about hunting fordisease genes in the human genome. Huntington Willard of Case Western Reserve University in Cleveland, will speakabout artificial human chromosomes, which researche...Genes May Affect The Response To Drugs That Treat Mental Illness
...g for receptor proteins may affect their function, expression orbinding affinities for antipsychotic drugs which may in turn alter the drug'stherapeutic action. This hypothesis was supported by the finding, made byresearchers at The Institute of Psychiatry, University of London, England, of anassociation betwee......ructure of telomeres, and the properties,roles and expression of telomerase discusses the importance of telomeres and telomerase in cancer and ageing, aswell as in DNA repair CONTENTS The telomere and telomerase: how do they interact? E. BLACKBURN, A. BHATTACHARYYA, D. GILLEY, K. KIRK, A. KRAUSKOPF, M. MC...Memorial Sloan-Kettering Investigators
...ranscription factors -- such as RAR -- turn on the expression of othergenes with specific functions, such as con...F-RAR gene fusions turned off,or "repressed," the expression of the cell's genes that normally prompt a cellto mature into a healthy, functioning white blood cel...Fauci: New Findings Help Explain "Rebound" Of HIV In Patients Who Discontinue Triple-Drug Therapy
..., i.e., by deliberately inducing virus expression in the setting of HAART," says Dr. Fauci. NIAID researchers are currently testing this approach in HIV-infected volunteers receiving IL-2 and antiretroviral drugs at the NIH Clinical Center in Bethesda, Md......., the biological consequences of heatshock protein expression in early embryos, and the unpredictability oftempe...'s early embryo is a specific mechanism to prevent expression ofHsp70. This preventer mechanism remains in place only through the most rapidphase of cell division...