What happens when genetic information is not correctly edited in brain cells
...o in certain cells an editing process during their expression as RNA templates for protein synthesis (see figure). Editing of RNA is a rare process that has been observed in mammals only in few cell types. Editing of RNA means that one or a few nucleotides in the RNA become altered. This alteration of nuc...Rosetta Inpharmatics approach enables identification of gene functions
...demonstrating how high quality, comprehensive gene expression analysis data and powerful computational methods c... able to generate a database of comprehensive gene expression profiles of cells with a wide variety of phenotypes and following different chemical treatments thro...Tailoring new cotton genes for industry
...ly identifying but modifying genes that find their expression in fibre cells. "We have isolated the controlling ... are fibre-specific, they can be used to drive the expression of other genes, such as pigment genes," she said. "Manipulation of genes such as these could improve...Canadian scientists find potent antifreeze protein that equips insects to brave winter
...oteins from different sources, and the cloning and expression of their genes to produce recombinant proteins for three-dimensional structural analysis by nuclear magnetic resonance spectroscopy and X-ray crystallography. The rather unusual beta helix structure of the antifreeze proteins of the spruce budworm ...New gene monitors cell division, cancer clinical applications seen
...ines found chfr to be inactivated, through lack of expression or mutation, in four of the eight -- fully half of the cell lines studied. Mitotic checkpoint genes identified in earlier studies had been linked to cancers, too, but mutant versions had been found in only 1 or 2 percent of cancers. "The frequency o...Gene 'shaving' could help doctors predict the efficacy of cancer treatments
...identify distinct sets of genes whose variation in expression could be related to a biological property of the s...eam. "In the present example, finding genes whose expression correlates with patient survival is an obvious challenge." The team used more than 4,500 gene expr...New protein a key to cell shape and movement
... then diminishes later in the cycle. "So again its expression correlates with these very dynamic structural changes," Otey noted. "That's why we think there's clearly a role for palladin from the point of view of the embryo and the point of view of the placenta." Still, as the researcher points out, exactly w...Genetic 'switch' key to biotech patent royalties
...ers a genetic sequence that can turn on or off the expression of genetic traits encoded in sections of DNA. Keller's lab pioneered genetic engineering in the state when the first gene cloning experiments were conducted at UAF in 1987. Recognized as the double-helical structure of heredity, DNA resembles a spi...Dairy scientist advances field of transgenics and knowledge of growth hormones
...ructs, which were put into animals to optimize the expression of proteins in their mammary glands. This led to the successful production of the first transgenic pig in the United States." Aker's research contributions to the Red Cross program, which began in the late 1980s, continues to influence the current p...Virginia Tech teams with US Army on exercise research
...ls the speed of the working muscles, thus allowing expression of more force than free weights over the entire range of motion. The contrasting exercises in the study will be a concentric type (muscles shorten while contracting) or eccentric type (muscles lengthen as contraction occurs due to external force). Th...Molecular switch that inhibits fat cell development found
...es. "We plan to use genetic engineering to direct expression of Wnt 10b to the developing adipocyte," says MacDougald. "Our goal is to create a fat-free mouse."...UCSF researchers identify regulator of critical brain messenger, hinting at therapy
...ht simply involve taking a drug that increases the expression of the gene that produces the protein transporter. The resulting increased expression of the protein would enable nerve cells to store and release more glutamate. "We've never had a drug...'Fat switch' fights flab at the cellular level, Science authors report
...urface to its interior, eventually influencing the expression of genes. Because signal transduction alters gene ...entists examined how the Wnt-1 protein affects the expression of genes that regulate fat. In cells expressing Wnt-1, the two fat-transcription factors were undete...Colorado set to fly biomedical experiments on September shuttle flight
...experiment to demonstrate interactions in the gene expression in kidney cells in low gravity. The kidney-cell e... Tulane researchers want to better understand gene expression in space-cultured kidney cells and develop new applications related to tissue engineering, said Klau...Plant's PICKLE gene may hold clue to cancer
...ch flips the biochemical off-switch that stops the expression of embryo characteristics. The two switches operat...hat protein, it can't throw the off-switch to stop expression of embryo-like traits after seed germination. Because both biochemical switches are in the "on" posi...Science: Prion proteins may signal trouble -- literally
...urface to its interior, eventually influencing the expression of genes. Because signal transduction events can alter gene expression, such processes can control tissue differentiation, cell homeostasis (or cell functions), cell death, and disease. By tracing signaling pathways, many hope to identify strategies ...Researchers discover major diabetes susceptibility gene
... allele of the high-risk version alters calpain 10 expression in the insulin-producing Beta cells of the pancreas, and the other allele alters expression in muscle or fat cells, tissues that either use or store glucose. Because the discovery was so sur...Study appears to show why muscle decays mysteriously in cancer, AIDS, other illnesses
...and turns genes on and off like a switch, prevents expression of a key regulatory protein called MyoD from replenishing muscle tissue as it does in healthy people. A report on the work appears in the Sept. 29 issue of Science. Authors, all of the UNC-CH School of Medicine's Lineberger Comprehensive Cancer Cent...Little-known substance regulates inflammatory response
...mation in multiple tissues. "We found that rapid expression of A20," said Ma, "was absolutely essential for down-regulating the inflammatory response and averting the damage unrestrained inflammation can cause in multiple tissues." Within three to six weeks after birth, mice without the gene for A20 spontaneo......gest that pairing of PGC-1with PPARa specifies the expression of cardiac mitochondrial components. The importance of maintaining tight control over this regulatory system is seen in the phenotype of transgenic mice expressing PGC-1 constitutively in the heart. These animals show a dramatic proliferation of c...