A New Molecular Marker For Prostate Cancer
...rundetectable levels of the protein. Decreased p27 expression was strongly associated with an increased rate of tumorrecurrence. Men with the lowest p27 expression had a more than three-foldincreased risk of recurrence, and more than eight-fold increased risk of d......ion of ROI, cytoplasmic rearrangements, and the expression of some infection-related genes. To trigger local cell-wall thickening, the fungal infection tube may have to penetrate the plant cell wall. As soon as the fungal infection tube is in contact the plasma membrane of the plant cell, the eli...Molecular Marker May Identify Bladder Cancer Patients Most Likely To Recur
... p21 protein and alsotested for alterations in the expression of the p53 tumor suppressor protein. Scientists fo...incegenetic changes in p53 may lead to loss of p21 expression and function. This inturn leads to unregulated cell growth, and is thought to contribute to theaggre...Hallucinations In Schizophrenia: Genetic Findings
...5-HTTLPR) produces significantdifferences in 5-HTT expression and function. The authors investigatedwhether 5-HTTLPR is associated with psychosis by genotyping 50 schizophrenicor schizoaffective patients at 5-HTTLPR and conducting double-blind BriefPsychiatric Rating Scale (BPRS) ratings while the patients were...Scientists Discover New Players On The Gene-Activation Team
...moleculespreviously unknown to be involved in gene expression plus unexpected dynamicsamong these molecules, which work together as a team to activate genes. "Gene-activation is a factor in diseases involving cancers, viruses,and hormones, and we now are starting to get a much more detailed understandingof how ......ve research on many fronts. Apoptosis involves the expression of cell-deathgenes inside a particular cell. For example, apoptotic genetic programs causesome types of cancer cells to die. "But in the brain, programmed cell death technically only occurs indeveloping brain cells in utero," explains McInto...The Best Molecular Snapshot Yet Of Cells Affected By Alzheimer's Disease
...at are turned on. Of the 20 genes tested, the expression of five genes --cyclin D1, HSP27, GAD, alpha 1-ACT and wee1 -- differedsignificantly between the healthy brains and the Alzheimer'sbrains. Some of these are cell-cycle genes, regulating celldivision and telling a cell when to die. Many are the same c......rtant, however, the team found that blocking Par-4 expression counteractedthe adverse effects of the presenilin-1 mutations. "These findings suggest that Par-4 plays an important role in both therare early-onset inherited forms of Alzheimer's disease and in the more commonsporadic late-onset forms of th...Study Finds Evidence Linking The Brain's Cognitive Control Regions With Stress Control Regions
...University has pinpointed distinct patternsof gene expression that indicate stress causes selective increases in... There was a significant amount ofstress-generated expression of GAD67 in the hippocampus and hypothalamus. Theinduction was rapid and transient, suggesting an i......es, producing genetic evidence that the lossof p27 expression in prostatic tissue of elderly men may be causally linked toBPH. Memorial Sloan-Kettering Cancer Center is the world's oldest and largestprivate institution devoted to prevention, patient care, research, and educationin cancer. Throughout it...University At Buffalo Team Discovers How The Cell Nucleus Orchestrates Genetic Processes
...ocesses are activated, apparently influencing gene expression andregulation. The work is reported in the current issue of Science (Sept. 4, 1998, Vol. 281,p. 1502-4). Like a conductor waving a baton, the UB team reports, the intricate nuclearstructure somehow orchestrates certain regions or "zones" in the nucl...Hopkins Researchers Discover Key Target In Molecular Pathway That Initiates Colon Cancer
..., have found that the mutated APCgene controls the expression of c-MYC activation. APC was first identified andlinked to colon cancer in 1991 by research teams including those led byVogelstein and Kinzler. Every person carries the c-MYC oncogene, but it remains under control in thecolon until APC inactivatio...Glowing Cyanobacteria Gives Researchers New Clues To Circadian Rhythms
...loop that drives the circadian clock. "The expression of KaiC is critically important for setting the phase ofthe clock," said Golden. The researchers found that the levels of kaiC geneexpression increase during daytime and decrease during nighttime. But anoverabundance of KaiC protein through either ...Loss Of Tumor Suppressor Gene Triggers Colon Cancer
...way. So c- MYC is probably not theonly gene whose expression is controlled by APC. We are working to findthe ot...m plans tobegin screening compounds that can block expression of the c- MYC oncogene through interference with the transcription factors regulatedby APC. In 1991...Hutch Researcher Wins 'Nobel Prize Of Applied Research'
...lso is notedfor its ability to achieve stable gene expression in those targeted cells,potentially yielding long-... of Health, it is the first time a retroviral gene expression kit has been madecommercially available. "It's technology that's been around for a while, but we're...Cubist Pharmaceuticals Describes New VITA™ Technology For Enabling Genomics For Drug Discovery
...t a lethal infection by the regulatedintracellular expression of a peptide inhibitor of an essential target. "Other target validation technologies, such as gene knock-out studies, antisenseinhibition of RNA and ribozyme technologies are indirect methods for assayingthe role of protein targets during an infecti...Gene Therapy In A Liquid May Lead To Quicker, Easier Methods For Treating Disease
...genenoninvasively, we could achieve long-term gene expression through a simple oralroute, and there was enough gene expression to treat a disease such as lactoseintolerance." The work has potential applications for tre...NASA Using Space Incubator To Understand Breast Cancer
...h of the ATM genes, for example, sets a course for expression of a devastating clinical syndrome called ataxia-telangiectasia, or A-T, which includes an approximately 100-fold increased risk of cancer. On the other hand, studies by Dr. Mike Swift and coworkers have shown that when only one ATM gene is damaged (...Virginia Tech Scientists Studying Cells From Extreme Environments
...ne, referred to as high throughput coupled-invitro expression cloning-fluorophore assisted carbohydrate electrophoresis(HTC-IVEC-FACE). The project will involve a diverse range of researchers including graduate andundergraduate students who will be trained in the new developing area offunctional genomics. Potts...Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness
... as you can design a ribozyme that could block the expression of the mutant gene, this approach ought to work," Lewin said. In addition to Lewin and Hauswirth, Kimberly Drenser, a UF student pursuing her medical and doctoral degrees, played a significant role in the study. UF's research has been supported by t...