Mice Lacking Gene Show Reduced Alcohol Preference And Sensitivity
...s lab is now workingon generating mice in which D2 expression can be regulated. "D2 is expressed inmany parts of the brain. In some areas the receptor is important for locomotion,in others D2 receptors regulate the synthesis and release !!of dopamine itself. Continuing work will focus on isolating the location ...Researchers Make Breakthrough In Gene Transfer
...Sinai School of Medicine, says that the "long-term expression offoreign proteins in a noncytotoxic manner may bl...cloned the mutant RNAsfor use as noncytotoxic gene expression vectors. They also made vectors thatcould be launched from DNA copies of the RNA. "The basic idea is...New Hypothesis Proposed For Cause Of Chronic Fatigue Syndrome
...7;Our data suggests that stress may be causing the expression of certain viral proteins and that these proteins may be modulating the body’s immune response, turning it on or off,” Glaser said. CFS was first characterized by researchers in the mid-1980s who described it as a combinat...Cedars-Sinai Scientist Finds Malignancy Gene In Tumor Cells
... Dr. Ljubimova explained, "theresult of looking at expression of another gene (c-met proto-oncogene) in normalan...s of 30 liver and five brain disease cases for MAG expression hasindicated its potential importance in liver and brain neoplasia. The absence ofMAG expression in ...Viral Vector Delivers Dystophin Gene To Mouse Muscle
... reported the vector's ability to induce long-term expression of thefull-sized dystrophin protein in an immuno-deficient strain of adult mice withDuchenne muscular dystrophy. At this year's meeting, Giovanni Salvatori, Ph.D.,post-doctoral research fellow in Chamberlain's lab, reported the same results inmice w...UNC Researchers Reduce Arthritis Severity By Turning Off Molecular Switch
...for NF-kappa B inarthritis because it controls the expression of numerous inflammatory genes, andwe knew that it's activated within the arthritic synovium. Around that time, ourcollaborator, Dr. Al Baldwin, published his pioneer study demonstrating thatactivated NF-kappa B is needed to protect cancer cells in v......e, the repressor fallsoff the DNA strand, allowing expression of agene that goads the bacterium into attacking its host's cells. "Until now, nobody knew just how bacteria translated a shortage of iron into aheadlong assault on the body's tissues," Ringe says. This chain of events is part of the battle our immun...First Derivation Of Human Embryonic Stem Cells Reported In Science
...nd tissues in the body; and, consistent with their expression of telomerase, self-renewing, a potentially limitless source of cells. "Geron is focused on developing products to treat age-related degenerative diseases. The availability of hES cells opens extraordinary opportunities for tissue transplantation, a...EMAP II: A Cytokine Regulated By Apoptosis
...cell death. Little was known about the expression of EMAP II or the regulation of its cleavage. S...gical Research in Bad Nauheim have analyzed the expression pattern of the EMAP II gene during embryogenesis of the mouse and found that the EMAP II messenge...Counting X Chromosomes To Determine Sex
...sthat gene's expression. SEX-1 may prevent xol-1 expression by simplygetting in the way of factors that permit that pivotal gene to be turned on. Still, SEX-1 is just one signal. Other X signals need to accumulate—andmay even cooperate—to inhibit XOL-1 activity enough for normalhermaphrodite develo...When One Gene Has Two Roles, Its Second Function May Be Missed
...ital system." The researchers conclude that GATA-2 expression in developing genitourinarytissues must be governe...d how these elements work." Derangements of GATA-2 expression could underlie any of a wide range of humanconditions. The researchers note that developmental abnor...Molecular Mission Unveils New Genetic Link To Common Birth Defect
...emice from death--the DNA sequences accounting for expression of the gene in thekidneys, ureters, and bladder we...controlelements--specifically, those governing the expression of the gene in tissuessuch as the genitourinary system--must reside hundreds of thousands of basepai...Penn Researchers Awarded $10 Million Grant To Study Link Between Genes And Hormone-Related Cancers
... toevaluate the effect of hormone exposures on the expression ofspecific genes. The innovative combination of population-basedstudies and basic science studies into a single project couldprovide insight into multiple aspects of hormone-related cancers. While many women may be exposed to hormonal compounds that...Two Brandeis Scientists Shed Light On The First Photoreceptor Known To Set Circadian Rhythms
...geneticmachinery that allows the clock to regulate expression of a variety of genes,"says Hall, a professor of biology. "We now have a pretty good idea of how thefirst of these three parts works." Rosbash and Hall fingered the clock-setting cryptochrome protein and itsaffiliated gene, cry, in work with...Duke Study Finds More Genes May Be Affected By Toxic Cadmium
...31 "unique C. elegans gene products whoselevels of expression (mRNA production) increased following cadmium expo...ow that there may be 22 novel geneswhose levels of expression increase in response to cadmium," he added. Because different genes are activated at differe...Molecular Mechanism For Evolution Described
...f the paper inthe November 26 issue of Nature. The expression of these variations depends on a protein called heatshock protein 90 (Hsp 90) which normally keeps certain inherent geneticvariations in a population silent, but can reveal them during times ofstress, such as climate change. All organisms make heat s...Shedding Light On Circadian Rhythms
...circadianpacemaker in mammals. They also knew that expression of the Cry1 gene within theSCN follows a circadian...ice to measure whether the absence ofCRY2 affected expression of another gene, called mPer1, that is known tooscillate in a circadian manner. In mice that lacked ...Researchers Externally Regulate Gene Implanted In Brain
...its analogstriggers the fusion protein to suppress expression of a gene delivered by thevirus. The viral vector was then injected directly into the brains oflaboratory rats. The protein expressed by the reporter gene served as abiochemical marker that the gene had been transferred successfully. Subsequ......ctions. Lipscomb's laboratory designed an expression system so the scientistswould have enough of the proteins to study. They used a common expression systemusing a bacterium called E. coli to serve as a host to the proteins, which areexpressed as the......tion in the MMP-1 gene thatinfluences its level of expression is important to our understanding of how thisenzyme modulates extracellular matrix metabolism, " said Brinckerhoff. Thecontinuous production of the enzyme, she adds, could be a factor in tumorinvasion and metastasis. Other team members included DMS ...