First gene defect identified for precursor to adult diabetes
... shifting mix of many factors. "While the expression of some diseases like cystic fibrosis arecontrolle... Theselifestyle and related factors can affect the expression of genes."Indeed, the disease has been called "the geneticist's nightmare." In June, at the annual m...Understanding serotonin receptors can speed treatment for depression
Manipulating gene expression levels in rats' brains can help to understand thecauses of clinical depression, according to psychiatric research at HarborviewMedical Center. Depression may stem from low levels of serotonin, caused by malfunctioningcomponents of the serotonin neur...NSF grants provide boost to research on inner workings of plants
...earch in Rockville, Maryland, will study such gene expression on a chromosomeand genome-wide scale. This information will be invaluable in getting the firstsnapshots of how plants develop at the molecular level, researchers believe. Unlike animal cells, plant cells are surrounded by walls largely made ...Millennium and the Whitehead Institute identify novel protein important in fat absorption
...of theseproteins in mice and six in humans. FATP4 expression is very high inenterocytes, while other members of the family are expressed in other tissues. We are excited about the potential therapeutic impact of this gene discovery." "The discovery of FATP, which is currently in small molecule drug discovery a...New technique identifies M. tuberculosis genes
...sis. The SCOTS technique allows us tocompare gene expression in M. tuberculosis in response to differentenviron...ifferent situations where you want to compare gene expression in two differentenvironments."...Genetic on-off switch found at Purdue could turn on gene therapy
...py and other systems where tight control over gene expression iscritical." The on-off switch discovered by Kohlhaw and his co-workers at Purdue consists oftwo main parts. First is a regulator protein (Leu3p) that, by itself, inhibitsthe action of any gene under its control. Second is the inducer(isopropylmalate...Jellyfish protein illuminates active immune cells
..., the two stick together. This meeting alters gene expression in bothcells and triggers an immune response. Mo...T cell's nucleus where molecules that control gene expression arelocated. He had preliminary evidence that suggested that the protein MEKK2concentrated around the......, pig cells aremodified to reduce or eliminate the expression of certain pig sugars which aretargeted by the complement-triggering antibodies. Second, dopamine-producing pigcells are further modified to express a protective shield of human complementinhibitor proteins. Third, the transplant recipient will be ad...Yale and Alexion report advance in spinal cord repair
...they produce pigcells that reduce or eliminate the expression of certain pig sugars which aretargeted by the triggering antibodies. Second, the company designsmyelin-producing transgenic pig cells that are covered by a protective shieldof human complement inhibitor proteins. "This particular study showed that,...Breast-feeding plays second fiddle to work, study finds
...pace and break time for the expression of breast milk could be key to increasing how long and how often a woman breast-feeds. "If women can find a way to balance breast-feeding and work demands, the effect of work on de...New tool for comparative gene studies
...ffects." Previously, the opportunity to study gene expression in non-model organisms was very limited. Technique... molecule which is required for the maintenance of expression of another protein, called 'engrailed' (en). Together, wingless and engrailed direct segment polari...Science and Amersham Pharmacia Biotech award Young Scientist Prize
...entists have an inkling of how a few cases of gene expression relate to certain kinds of cancer, but lack an ove... that SAGE could be used to profile the total gene expression in both tumor and normal cells, so that researchers could compare the two and decide whether changes...A molecule family hinders spinal cord regeneration, UF brain institute team finds
...UF experiments also were the first to look at CSPG expression in cellular transplants. "We were very surprised to see that the CSPGs increased rapidly, not only in the host around thetransplant, but in the transplanted tissue itself," said Dena R. Howland, a research assistantprofessor of neuroscience in UF's ...UroGenesys researchers discover new target antigen for prostate cancers
...ncluding metastatic tumors. Its prostate-specific expression suggests thatdrugs targeted to STEAP may have a fa...ssues. Theresearchers confirmed high cell-surface expression of STEAP in all human prostate cancer samplestested, and further showed that expression of the prote...Zebrafish's powerful heart gene could lead to transplant therapy
...e researchers demonstrated that gata5regulates the expression of a gene known as nkx2.5 which, when mutated inhumans, causes human congenital heart defects and disease. Human geneticistsand cardiologists studying families with heart disease may discover, saidStainier, that a mutated form of the gata5 homologue...Neurosteroids: the missing link?
...s produce their effects over time by altering gene expression in thenucleus of the cell," said Morrow, first author of the symposium proceedings. "This might occur overhours or days. Neurosteroids produce their effects by interacting with neurotransmitter receptors andthen altering neurotransmission, producin...MGH study identifies new inhibitor of tumor angiogenesis and growth
... tumor growth and angiogenesis, it also shows that expression of bothproteins completely stopped growth of the tumors studied in this project. The researchers introduced TSP-2 DNA into cultured cells from human squamous cell carcinomas -tumors that do not normally produce TSP-2 - and injected the cells into th...Consortium focuses on new mouse models of human cancers
...or cancer researchers. Recently, an abnormally low expression of this receptor was recently identified by VICC i...oped mouse models for down-regulated TGFb receptor expression in the breast, prostate and colon, with evidence already suggesting premalignant and malignant chang......he research team found in women an increase in the expression of the gene for gastrin-releasing peptide receptor...vered that nicotine found in cigarettes stimulates expression of the GRPR gene in lung cells. "Our research strongly suggests that women are likely to de...Researchers find new mechanism for growing new blood vessels
...hypoxia-inducible factor (HIF)-1alpha, it turns on expression of multiple angiogenesis-related genes, including ... VEGF and its receptors. Also, PR39 stimulates the expression of receptors for another family of potent inducers of angiogenesis, fibroblast growth factors (FGF)....