First genetic toggle switch engineered at Boston University
...e researchers were able to successfully switch the expression of genes between stable on and off states by apply... a synthetic bistable on/off switch to control the expression of a gene - a switch that can be generalized to a variety of genes in many different organisms, incl...Scientists develop most efficient mouse cloning strategy to date, create transgenic clone
...bryonic stem cells need less reprogramming of gene expression (i.e. turning back of the developmental clock) than somatic cells. This and other information from ES cell cloning will help researchers maximize cloning efficiency. Finally, this study points to a new way of making transgenic animals that could ......cells need for signaling, gene expression and cell division: the Smads. ... of the Smad proteins to promote gene expression is strongly enhanced," he said. "If you strengthen the microtubules, they then ...Photoreceptor gene mutations cause degenerative eye disease
... Sheffield and his colleagues also found that the expression of NR2E3 is specific to the nuclear layer of the...tions than answers. If signaling mistakes in the expression of NR2E3 are the cause of ESCS, how might this happen? One hypothesis is that cone cells become bl...Life on land tied to gene expansion
...s. "So you get expansion of gene expression--not expression of a new gene--just expansion to a new area," says... were true, a defect in the promoter should affect expression in the brain as well as the skeleton. But the researchers found that while mutant mice carrying such......r example, provide valuable information about gene expression -- when, where, and to what extent specific genes are active. This information is critical to understanding a gene's biological function. But gene chips, like genomic sequencing technology, produce enormous amounts of data that can only be analyzed a...Gene transfer improves function of aging hearts in animals
...this study is the first to show that altering gene expression could improve the more common heart abnormalities ...thor. "The knowledge that increasing SERCA2a gene expression might improve function of the aging heart gives us a target for therapies that might prevent people ...Protein that stimulates blood vessel growth also helps repair broken bones
...owth. The VEGF-injected mice also had much higher expression of the gene Cbfa1, which is thought to help stimulate formation of new osteoblasts. Although more research is necessary, VEGF treatment could help to give a happy ending to the tragic stories of patients who suffer from non-bony healing, said Ted ......ne of the first few studies that has looked at the expression of metallothionein in the brain," said Michael Aschner, professor of physiology and pharmacology at Wake Forest University School of Medicine. "There are different types or forms of metallothioneins in the body, and we don't know exactly what they'r...Bitter taste receptors identified
...t there was even better news. "If you look at the expression of this new family, you find that every cell that expresses one of these receptors is a gustducin-expressing cell," says Zuker. Next, the researchers screened libraries of mouse genes in a search for the mouse versions of the new gene family. Mice a...Purdue researcher finds space fertile arena for gene transfers
...rol group showed the trait. "The rate of transient expression in a space environment was more than tenfold over the success rate of a comparable terrestrial experiment," Vierling says. Those experiments seem to indicate that space may be a better environment for conducting gene transfers. "Genes were transferre...How a hormonal henchman triggers death
... found that a puzzling burst of protective diap2 expression occurred right before reaper and hid were activated. "This burst of activity does support models that diap2 normally holds back the death response," said Thummel. "But we still don't know why the salivary gland really cares that it's only got ...Cockroach birth control from gene discovery
...cockroaches, while subsequent tests found the gene expression only in male adults, and finally, only in the male...y the hormone or other protein that is produced by expression of the insect's P450 gene, and then develop chemical inhibitors of the proteins that would be includ......apping but clearly distinct anatomical patterns of expression in the brain," said Rosenfeld. "Also, previous research had found that Crhr2 also responds to a different chemical trigger, called eucortin. "So, we set out to differentiate the potential distinct roles of the Crhr2 receptor by creating a mouse in w...The genetics of aging: New study says cell division errors may be the common link
...oduct is a new cell. As we get older, altered gene expression results in cells with diminished function." Dr. Le...re Key Errors in cell division lead to the altered expression of a collection of key genes in the cells. Altered gene expression gradually causes the loss of tiss...Unique study reveals new details on how genes are transcribed
...observations provide new insights into how genetic expression in cells may be regulated. Carlos Bustamante, a bi...has direct implications for the mechanisms of gene expression in both bacteria and eukaryotes." The genetic messages stored within the DNA inside the nucleus of ...Exisulind (Aptosyn™) and other SAANDs compounds halt prostate cancer cell growth by two mechanisms
...lls by inducing apoptosis. Secondly, they decrease expression of the androgen receptor in the cancerous prostate...er SAANDs, CP461 and CP248, inhibited the cellular expression and secretion of prostate specific antigen (PSA) at the same concentrations that induced apoptosis i......by a mechanism involving the inhibition of a novel expression of cyclic GMP phosphodiesterase (cGMP-PDE). As inh...MP-PDE inhibition by Aptosyn™ through relative expression of various PDE families. Specifically, they noted that Aptosyn™ induced the expression of PDE2 b...UC Berkeley biologist disputes current dogma that genetic mutation is the cause of cancer
...f proteins. They found thousands of proteins whose expression was doubled in cancer cells. "It's not a small num...ssion, but a large number with a small increase in expression that transforms a normal cell into a cancer cell," Rasnick said. Support comes from a number of scie......rmone, their fat cells changed the profile of gene expression in a distinct way, indicating that at least part of the effects of leptin are due to a regulation of gene expression. Many genes appeared that were known to be regulated by a protein named SREBP-1, including SREBP-1 itself. SREBP-1 is known to play a...