Mouse genome revealing which DNA sequences activate human genes
...ces that play an important role in regulating gene expression is the key to the success of this study, just as it has been a key to identifying DNA sequences that code for genes across different species. "If evolution conserved a sequence over the 70-90 million years since mice and humans diverged, it likely h...Researchers identify novel penicillin-resistance gene in pneumonia bacteria
...pe. How exactly the murMN genes contribute to the expression of penicillin is not clear yet. Branched muropeptides may compete with penicillin for a site on the resistant PBPs, or they may perform some yet-to-be-identified signaling function in cell wall synthesis or occupy strategic sites within the cell wall...Nearly identical controls of immune genes in mice and humans hint at new asthma treatment
...ity of this region, we should be able to block the expression of all three genes." Many drugs are now being d...id. Targeting a region of the genome that controls expression of the three genes at once may offer a solution. The demonstration that the human genes for IL-4, 5...New genes protect trees from insects, disease
... plant signals and determine the symbiosis-related expression of genes. If we can combine a specific gene with ...ol of symbiosis-related gene promoters, then their expression will be limited to mycorrhizal roots and thus will not cause any unintended expression of these gene...'Obesity gene' causes cancer of fat tissue, Schepens scientists find
... is likely that therapeutic agents which block the expression of the HMG I-C would be effective in the treatment of these two major clinical problems ," said Santa J. Ono, Ph.D., Associate Scientist at The Schepens Eye Research Institute and Associate Professor at Harvard Medical School. Ono and his colleagues ...Gene tug-of-war leads to distinct species
... easily changeable control elements that alter the expression of genes, but do not affect their DNA sequence. An epigenetic theory of speciation is attractive to some researchers because the gradual accumulation of genetic mutations that is needed to produce distinct species is considered by some to be too slo...New genes and old genes contribute to personality traits
...r regulatory regions, one might speculate that the expression of different isoforms of AP-2 influences mood and personality, not only due to their role during the development of the brain, but also due to their function during adulthood. AUTHORS: M Damberg, H Garpenstrand, J Alfredsson, J Ekblom, K Forslund, G......unday at the University of Tasmania, measured gene expression in two monotremes, the platypus and echidna. Neither animal had imprinted copies of the M6P gene, which did not affect the actions of IGF2. But in the American opossum, a marsupial, M6P does oppose IGF2, and is maternally imprinted as in people, the ......67, 1999). Together with a detailed mapping of the expression of calcium-activated potassium channels (SK channe...d SK3) present partially overlapping, but distinct expression patterns in the rat brain. In the hippocampus, a brain region important for learning, memory consoli...... from clinical studies on the safety, transfer and expression of RPR/INGN 201 (Adenoviral p53) in three Phase I clinical studies for the treatment of bronchioalveolar cell lung carcinoma (BAC), ovarian cancer and recurrent glioblastomas at the 36th American Society of Clinical Oncology (ASCO) Annual Meeting in ...New robotic microarray technology finds novel genes involved in cardiac hypertrophy and recovery
...ivision, Friddle used the technique to monitor the expression of up to 10,000 genes at a time. "Of an estimated...any false positives. The question isn't how big an expression effect is, but whether expression can be replicated." The researchers screened for such factors as g...Genomics project aims to create a "virtual plant"
...r example — how organisms alter their genetic expression in response to the environment. "Plants more than almost any other organism change their development in terms of their environment," she said. "And since they are an easily manipulated system, we can begin to ask some very fundamental questions abou......fourth, the bacterium doesn't appear to alter gene expression in response to iron-limiting conditions. Finally, by using mass spectroscopy and radioactive iron transport techniques, they found that the levels of iron inside the cells of B. burgdorferi are 1,000-fold less than those measured in other pathogenic...McGill launches Centre for Bioinformatics
...ful analysis by accumulating accurately timed gene expression data. This work will identify novel control points to target pharmaceuticals. 3. Structural biology: A key problem is to figure out the structure and function of biomolecules based on the sequence information, and to rationally design new drugs...Targeted genetics presents promising data from cystic fibrosis clinical trial
...ve that the good safety profile and long-term gene expression properties of our AAV vectors make them a promising approach to treat a variety of chronic diseases such as CF, hemophilia and rheumatoid arthritis. Our strong intellectual property portfolio in the area of AAV vectors for delivering the CFTR gene c...Targeted Genetics presents data on arthritis gene therapy
... "We believe that the safety profile and long-term expression properties of our AAV vectors make them a logical approach to developing a gene-based delivery system for this important therapeutic protein. Local delivery of AAV-TNFR:Fc to arthritic joints may allow patients to be dosed every few months while mai...Scientists issue telomerase caution
...ly extended the life-span of the cells. Telomerase expression was immediately recognized as a useful strategy fo...oratories had indicated that the use of telomerase expression to extend the life-span of cultured cells did not appear to transform these cells into a hyperprolif...Gene identified that may play role in psychological disorders
...parated into two groups based on each individual's expression of the 5-HTT gene. The researchers analyzed blood samples to determine how each subject expressed the gene. These subjects were considered "super-normal," because none had a history of psychiatric or medical disorders. "When studying a risk fact...Modified HIV may be effective for delivering and regulating gene therapy
...s that doctors may someday be able to control gene expression in people who are treated with gene therapy vector...owth hormone. And if adverse affects develop, gene expression can be curtailed. The new study was led by Tal Kafri, Ph.D., assistant professor of microbiology a......nt these processes in humans," Prolla says. "Gene expression changes observed with aging in the two brain regions can be used to measure the aging process on a tissue-specific and molecular basis," Weindruch says. "This should facilitate the development of interventions -- drugs, dietary modifications -- to re...