Tag: "familial" at biology news
PDF invites scientists pursuing Parkinson's research to apply for funding
... protein that has been implicated in some cases of familial
PD. To inquire about the IRGP or to request an application form, see the PDF website at www.pdf.org , or contact Sharon Stone, Director of Research and Special Programs, at the Parkinson's Disease Foundation at 212-923-4700 or by email at sstone@p...
Discovery of brain disorder gene paves way for genetic test
...paves the way for a new genetic test for the rare, familial
disease, which typically lies dormant in patients ...ication of this gene will allow more people with a familial
history of the disease to be tested early. If they are found to have the gene, physicians can then c...
Yeast model yields insights into Parkinson's disease
...rlier this year reported that patients with a rare familial
form of PD had too many normal copies of the alpha-synuclein gene, which resulted in a buildup of protein inside brain cells, causing the symptoms of PD. Drs. Outeiro and Lindquist conducted their study by creating one yeast that expresses wild type ...
Baboons identify each other by status and family
...d that humans can classify each other according to familial
or social status, but how did those abilities evol... and documented the existence of stable, long-term familial
hierarchies within the troop. Baboon groups contain a number of adult females arranged in a linear ...
Region of chromosome 1 important in blood pressure regulation
... such as type 2 diabetes and to a condition called familial
hyperlipidemia (in which levels of cholesterol are high). However, this is the first analysis to identify candidate genes for additional study and to offer good evidence that more than one gene in the region is involved in blood pressure regulation, ...
Major new finding on genetics of Parkinson's disease zeroes in on activity of alpha synuclein
Scientists investigating a rare familial
form of early-onset Parkinson's disease have disco...ns in several other genes have also been linked to familial
forms of Parkinson's disease. In this new study, investigators analyzed blood samples from another ...
New model of Alzheimer's enzyme may help refine future treatments
...e between two presenilin proteins and suggest that familial
forms of Alzheimer's disease are caused by inter-molecular interactions between mutant and normal proteins. The team was able to observe that exact phenomenon; however, the finding was fleeting and, thus far, has not been reproducible. "There are m...
Researchers discover new genetic link to common colon cancer
...cation on a human chromosome that can be linked to familial
cases of colon cancer--the type of colon cancer that tends to run in families. Research published today in the Proceedings of the National Academy of Sciences (PNAS article #2286) identifies a specific stretch of DNA on chromosome 9 that houses a ...
New gene for rare inherited paralysis may aid other spinal cord research, too
...is no cure for HSP, which is also sometimes called familial
spastic paraparesis or Strumpell-Lorain disease. T... that develops in early childhood and may resemble familial
cerebral palsy. That discovery, of a gene on chromosome 14 that encodes a protein called atlastin, h...
New study shows why hypertension affects black males disproportionately
...sted English as their primary language, and had no familial
history of HT. In accordance with the Institutional Review Boards, subjects provided written informed consent before being tested. The AA group consisted of 32 males and the NAA group consisted of 29 males. Via self-report, individuals with two pare...
JCI Table of Contents
... It has long been noted that while patients with familial
hypertrophic cardiomyopathy due to cardiac troponi... ACCOMPANYING COMMENTARY: Cardiac troponin T and familial
hypertrophic cardiomyopathy: an energetic affair AUTHOR CONTACT: Ketty Schwartz INSERM U582, Instit...
Researchers identify second gene responsible for rare syndrome associated with skeletal defects
...al conditions including a body-fat disorder called familial
partial lipodystrophy, muscular dystrophy, cardiomyopathy and a premature aging disorder called progeria. "It is likely that minor changes in these genes may predispose individuals to premature aging, a change of body-fat distribution, as well as os...
Pitt researchers find genes for depression; Play role in mood disorders, shorter lifespan
...e levels may contribute to a reduced proportion of familial
cases of depression among depressions that arise later in life. CREB1 is a gene that encodes a regulatory protein called CREB that orchestrates the expression of programs of other genes that play important roles in the brain and the rest of the body....
Tips from the Journals of the American Society for Microbiology
... lungs of all but 1 of 33 unselected patients with familial
or sporadic IPF, a frequency much greater than that for the lungs of the controls with other diseases," say the researchers. "Establishment of chronic pulmonary herpesvirus infection as the cause of IPF will require detection of a herpesvirus in the...
Misbehaving molecules in ALS
...ggests that the two most prominent theories of how familial
ALS (FALS) and other related diseases develop are ...gy, we could see the intimate details of how toxic familial
ALS proteins interact. And we found out that the proteins are interacting in a way they shouldn't b...
Study of thyroxine transporter molecule shows how key hormone hitches a lift round body
... light on the molecular basis of a rare condition, familial
dysalbuminemic hyperthyroxemia (FDH), which is caused by mutations in HSA. This harmless genetic disorder is often misdiagnosed as an overactive thyroid gland and treated inappropriately. Dr Stephen Curry of Imperial's Department of Biological Scien...
Researchers identify gene for premature aging disorder
...arie-Tooth disorder type 2B1, the Dunnigan type of familial
partial lipodystrophy, mandibuloacral dysplasia and a familial
form of dilated cardiomyopathy. Prior to coming to NIH to lead the Human Genome Project in 1993, Dr....
Fears grow over 'mad elk disease'
...the same period based on the rates of sporadic and familial
CJD elsewhere, he will tell the Honolulu meeting this week. That shows how ineffective the surveillance is, says Norman Foster, a neurologist at the University of Michigan in Ann Arbor. So if CWD-contaminated venison does trigger a new form of CJD in...
Studies of rare blood syndrome yield novel route to cancer
...nnot use the same strategies that one would use in familial
breast or colon cancer. There are no recurring chromosome abnormalities that could reveal an underlying cause." Careful genetic analysis by Cools revealed some interesting information: His work showed that a small deletion of DNA in a region between ...
Receptor could be target for cancer therapy
...number of pre-cancerous polyps in individuals with familial
adenomatous polyposis. Multiple trials are now underway testing COX-2 inhibitors for cancer prevention and treatment.COX inhibitors may not be ideal anti-cancer drugs, Breyer said, because they block the production of all prostaglandins. "Some of t...
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