Tag: "fibrosis" at biology news
Scientists Discover Molecular Trigger Of Mucus Production, Suggesting First Treatment For Deadly Bronchitis, Other Diseases
...blocking their airways. Chronic bronchitis, cystic fibrosis
and acuteasthma, all caused by blocked airways, af...witched off. "Hypersecretory diseases like cystic fibrosis
and chronic bronchitis take aterrible toll, but no drugs have ever been developed to cure them," sai...
Slimy Bacteria Common Cause Of Chronic Infections
... Ear infections, periodontitis and cystic fibrosis
pneumonia are just afew examples of the infection...ical problems thatcan result from biofilms. Cystic fibrosis
is about the best example of apersistent infection that involves slime, said Costerton, who has seen...
Cystic fibrosis gene undetected in screening of infertile men
More effective screening methods for cystic fibrosis
are needed to preventinadvertently passing on defe...utine panel is still effectivefor detecting cystic fibrosis
in the general population, it should be usedcautiously in patients with infertility. In addition to ...
Jefferson scientists further develop gene repair technique
...which will "set the stage for direct work incystic fibrosis
and other diseases that are caused by deletions of...ion in a gene causes more than 70 percent ofcystic fibrosis
cases. Dr. Kmiec had shown previously that the new gene repair technology mayhold promise as...
Target for cystic fibrosis drugs found
...y," the scientists describe the keysnafu in cystic fibrosis
transmembrane conductance regulator (CFTR), aprote...proposed eight years ago, that most casesof cystic fibrosis
are a result of a protein-folding problem," saysPedersen. "And now that we know what is broken at th...
Discovery might boost cystic fibrosis therapy
...the other hand, airway cells in people with cystic fibrosis
remove too muchliquid so that the coating becomes ... "This work definitely has implications for cystic fibrosis
treatmentbecause it shows we somehow need to block sodium channels to prevent excessiveremoval of sa...
Gene mutations not always expressed as complete disease
...ffects stems largelyfrom recent findings in cystic fibrosis
(CF). Writing in the July issue of Clinical Chemistry, Dr. Lawrence M. Silverman,professor of pathology and laboratory medicine at UNC-CH School of Medicine andDr. Kenneth J. Friedman, a postdoctoral research associate, note that mutationsin CFTR...
UNC-CH chemists develop better gene mutation detection method
...esponsible for medical conditions including cystic fibrosis
and cancer. Those alternations, called single nucleotide polymorphisms, occur whenone chemical component of the genetic code is changed in some way by additions,deletions or relocations of genetic material, the scientists say. Knowing whatand...
First gene defect identified for precursor to adult diabetes
..."While the expression of some diseases like cystic fibrosis
arecontrolled by just one gene, diabetes is likely to be affected by several,"Goldfine says. "Moreover, both insulin resistance and the subsequent developmentof diabetes are moderated by exercise, weight loss and hormone levels. Theselifestyle and re...
Asthma-linked genes discovered at Berkeley lab
...gle genes responsible for disorders such as cystic fibrosis
andsickle cell disease. Says Rubin, "The approach we used to pursue asthma genes may now be applied toother common complex genetic conditions, for instance hypertension and obesity,where large genomic regions have been implicated as containing gene...
Prestigious new nutrition research center being established at UNC-CH with NIH funding
...ups. Vitamin D therapy for bone disease and cystic fibrosis
will be the focusof Aris' work. "This new NIH support and designation recognizes and confirms theworld-class stature of nutrition studies in public health and medicine at theuniversity," Zeisel said. "It will create significant new opportunit...
A safer way of altering genes
...ticdefects such as the mutations that cause cystic fibrosis
at the start of life-byadding genes to embryos created by IVF-gene therapists treat people with geneticdisorders by adding therapeutic genes to specific tissues in the hope that theywill be taken up by enough cells to correct the defect. Whil...
Cystic fibrosis splicing experiments offer hope for improved treatments
... genetic problem that accounts for aform of cystic fibrosis
commonly seen in patients of European Jewish desce...inside a gene. When that gene is imperfect, cystic fibrosis
results. The two conducted the research in collaboration with Drs. Lawrence Silverman and Michael ...
Dartmouth research offers clues to new anti-microbial treatments
... says Taylor, might be a useful adjunct for cystic fibrosis
treatment by inhibiting the growth of Pseudomonas that colonizes patients' lungs and is notable for resistance to antibiotics. It might lead to particularly useful approaches against infections such as meningitis by providing a way to clear bacteria ...
Mice unable to synthesize vitamin C should become valuable research tool, scientists say
...mic a variety of human disorders, including cystic fibrosis
and thalassemia, an inherited form of anemia. One of his former students, Dr. Beverly H. Koller of UNC-CH's department of medicine, led the team that created the world's first animal model for cystic fibrosis, one of the most common genetic diseases ...
Northwestern scientists shed new light on neurodegenerative diseases
...om Huntington's and Alzheimer's diseases to cystic fibrosis
and Creutzfeldt-Jakob disease, the human form of mad cow disease. The findings provide a new model for understanding the common pathology of these diseases, knowledge that could lead to the development of effective drugs. The diseases, characteri...
Study shows receptor molecule facilitates introduction of corrected genes into cells
...er that, they will try to correct defective cystic fibrosis
cells in tissue culture, in mouse models of cystic fibrosis
pioneered at UNC-CH and, eventually, in human volunteers. "All of us are very keen to the notion th...
Targeted genetics presents promising data from cystic fibrosis clinical trial
...s gene therapy product for the treatment of cystic fibrosis
(CF). Dr. Thomas C. Reynolds, Vice President, Cli...roducts. Clinical trials of AAV vectors in cystic fibrosis
are in progress and additional preclinical data are being generated in the areas of hemophilia, arth...
MetaPhore reports general anti-inflammatory surface treatment for biomedical materials
... potent inhibitory effect on matrix production and fibrosis
on the implant surface, and A protective effect on poly(etherurethane urea) biodegradation in vivo "These dramatic results are, to our knowledge, the first description of a general anti-inflammatory surface treatment for biomedical materials," sai...
Scientists spot way around cystic fibrosis cells' poor performance, way to improve drug testing
...at appears to be a newly found regulator of cystic fibrosis
chemistry, scientists at Johns Hopkins report they...lps control the protein product made by the cystic fibrosis
gene, called CFTR. CFTR protein molecules shape themselves into channels in the cells that line the ...
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