Tag: "fibrosis" at biology news
Gene alterations for cystic fibrosis may also account for chronic sinus problems in some
...tions known to cause the inherited disorder cystic fibrosis
(CF), which is characterized by mucous membrane ab...123 people without sinusitis. Patients with cystic fibrosis
were excluded from the study. CFTR's usual job is to regulate the flow of salt and water across...
UI researchers develop test indicating cystic fibrosis lungs are infected with bacterial biofilms
...owa researchers indicates that the lungs of cystic fibrosis
(CF) patients are infected primarily with bacterial biofilms, organized communities of bacterial cells that are extremely resistant to antibiotic treatment. Infection by the bacterium Pseudomonas aeruginosa (P. aeruginosa) is the main cause of deat...
New technique will improve delivery of drugs and gene therapy for cystic fibrosis patients
...o reach airways in the lungs of people with cystic fibrosis
(CF). The work, reported in the October issue of C...r them to the right targets efficiently." Cystic fibrosis
is an inherited disorder in which cell channels that regulate salt flow fail to open, wreaking havoc...
Genes and gene delivery for diseases of alcoholism: a symposium at UNC
...to the liver, thus curing the development of liver fibrosis
and cirrhosis," Crews, said. "In presentations on fetal alcohol syndrome, we have H. Scott Baldwin of Children's Hospital of Philadelphia who has developed strategies of gene delivery to the fetus. And Kathleen Sulik, professor of cell and developmen...
Genomic leaders receive 2001 Biotechnology Heritage Award
...sponsible for diseases, including those for cystic fibrosis
and Huntingtons disease. He earned his Ph.D. in Physical Chemistry at Yale in 1974, and his M.S. from the University of North Carolina, Chapel Hill, in 1977. About J. Craig Venter Venter is president of Celera Genomics, senior vice president...
Researchers uncover a protein defect that causes a milder form of cystic fibrosis
... Biology. This discovery builds on years of cystic fibrosis
(CF) research at The Hospital for Sick Children (H...n't function properly in the milder form of cystic fibrosis
- segments of the protein are sticking together, interfering with the flow of chloride in and out of...
New statistical method links multiple genes to common complex diseases
... so only for a limited number of cases like cystic fibrosis
that are caused by mutations in a single gene. Where more than two genes are involved, however, traditional methods of analysis have floundered because it has proven impractical to acquire genetic information from the large number of subjects require...
Researchers identify gene for rare form of leukemia that strikes infants
...han two years of age and is often characterized by fibrosis
of the bone marrow. This type of leukemia also occurs in children with Down syndrome but the prognosis is particularly poor for infants without Down syndrome, with a median patient survival of only eight months. AKML accounts for up to 20 per cent of...
Cystic fibrosis patients show too little salt in lungs, will need long-lasting treatments
... this sticky mucus, which is the problem in cystic fibrosis
lung disease, Boucher said. They also revealed that you have to have long-acting compounds to do this in a way thats going to be clinically useful. The UNC project is an important step toward understanding CF lung disease and producing better treatm...
Findings on cell communication may help fight three genetic diseases
...ns move between the nucleus and cytoplasm. Cystic fibrosis
is a disease of protein transport along the secretory path. A single gene is mutated, and the corresponding cell surface protein normally regulates cellular chloride content, especially in the lungs. In most affected individuals, this protein is made...
Two routes to cell death in the diseased kidney
...erosis, a progressive disease involving glomerular fibrosis
and degeneration. One protein of the SMAD family, SMAD7, is well known as a negative regulator of TGF-b signaling, and indeed, TGF-b signaling often activates synthesis of SMAD7, establishing a negative feedback system that can limit the pathway?s ph...
Rutgers scientists mapping DNA links to complex diseases
... faulty genes as opposed to just one, as in cystic fibrosis
and sickle cell anemia. SNPs are key agents of change among the roughly 3 billion nucleotide base pairs -- the building blocks of DNA and genes -- that make up the human genome. While 99.9 percent of the genome is identical for everyone, SNPs ar...
DNA biochip may lead to fast genetic screening, more effective drugs
...reen for the genes linked to breast cancer, cystic fibrosis
or prostate cancer, for example," says Xiaolian Gao, a professor of biochemistry at the University of Houston. "This highly parallel technology allows us to do thousands or tens of thousands of experiments all at once." Gao says there currently are...
Study: control of chloride channels localized, discovery may boost cystic fibrosis treatment
...creas and skin. Often parents first suspect cystic fibrosis
when their infants skin tastes salty following motherly kisses. A child born to parents who each carry the defective CFTR gene faces a 25 percent risk of being born with cystic fibrosis. He or she has a 50-50 chance of being a carrier of CF and a 2...
Phenotypic variability in cystic fibrosis
(CF) is among the best studied and most common autosomal recessive disorders. Although CF is often described as a simple Mendelian trait, the clinical variability seen among patients hints at genetic or environmental modifiers. In particular, while C...
UNC, Duke researchers discover cause of mysterious pancreatitis in some people
...es the highly debilitating disease known as cystic fibrosis
or, in the words of some of its younger victims, 6...g two mutations in the gene responsible for cystic fibrosis
and increased 20-fold in people having a mutation known as N34S in the pancreatic secretory trypson ...
UNC-Chapel Hill gene therapy center awarded $9.2 million from NIH
...eases caused by single-gene defects such as cystic fibrosis
and hemophilia. Co-principal investigators for the...her has published more than 300 articles on cystic fibrosis
and gene therapy. In 1992, he helped develop a gene "knock-out" mouse model for cystic fibrosis. His...
Study suggests way to short-circuit microbe communication
...antibiotic-resistant bacteria. For example, cystic fibrosis
is caused by a bacterial film in the lung. Short-circuiting the bacterium's tendency to collect in a film by hindering its ability to communicate, could underpin new strategies for treating what is now an intractable disease. The discovery that synth...
Images reveal how body regulates salt uptake in cells
...n another type of chloride ion channel, the cystic fibrosis
transmembrane regulator, cause the most common genetic disease of people of European descent. In 1998, MacKinnon and his colleagues solved the crystal structure of the potassium ion channel. Potassium, which carries a positive charge, is used for si...
Scientists at The Scripps Research Institute show most people with the genetic mutation for an iron-storage disease stay healthy
...dinavian study, in which only 4 persons with liver fibrosis
were found among more than 65,000 subjects who were screened by determining their blood iron levels." Having the gene mutation alone apparently is not enough to trigger the disease process. "The low rate of iron-overload disease among people who hav...
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