Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
...as aeruginosa , which infects patients with cystic fibrosis and those with impaired immunity. Besides it's value in developing better anti-anthrax drugs, the finding is an important one for basic cellular biology. Calcium is not only used for bone formation but also plays a vital role in the communication be......BA has been approved in the US for treating cystic fibrosis and sickle cell anaemia, and seems to have few side effects. He and his team will be testing the drug on mice very soon....Hypoxic mucus favors Pseudomonas infections in cystic fibrosis
Cystic fibrosis (CF) is life-threatening primarily because the lungs of affected individuals are subject to persistent and intractable infections, typically with Pseudomonas aeruginosa. The properties of the tracheal fluids that support these infections in CF patien...Research uncovers new treatment target for cystic fibrosis patients lung infection
...of whether the debilitating lung infections cystic fibrosis patients suffer occur deep in the cells lining the...e had a problem with antibiotic therapy for cystic fibrosis in that antibiotics that were very promising in the laboratory did not work very well in patients, B...Researchers discover gene causing deadly infantile form of genetic kidney disease
...t of multiple fluid-filled cysts in the kidney and fibrosis in the liver. The disease is often associated with poor lung development and infant death. There is currently no treatment or cure for ARPKD, but the discovery of the ARPKD gene now provides researchers with a genetic road map for a functional unde...Genetic clues for finding and treating cardiovascular disease (CVD)
...gene, as is the case of sickle cell anemia, cystic fibrosis (CF) and Alzheimers disease (AD). By contrast, the family of disorders that constitute CVD typically result from more than one mutated gene. For example: More than 300 genes have so far been associated with cardiac hypertrophy. Genetic factors ar...New center to study deadly microbial pathogens
...ing in the world whether it's a child with cystic fibrosis in the United States dying from protracted infecti...onas aeruginosa: Individuals suffering from cystic fibrosis can die of chronic lung infection and inflammation caused by this bacterium. The organism is capable...Scientists reveal fine detail of cell's energy machinery
...sor Iwata. "Many genetic disorders such as cystic fibrosis are directly related to membrane proteins, and as many as 70 per cent of drugs currently available act through membrane proteins. "Solving the structure of membrane proteins is essential to facilitate the rational design of effective drugs and to d...New protein plays espionage role in bacterial attack on plants
...man proteins involved in disease, including cystic fibrosis and breast cancer. The Carolina researchers focused on the Arabidopsis disease resistance protein, RPM1, which they previously showed was anchored to the inside of the plant cell membrane. It is logical from an evolutionary perspective of defense tha...Researchers discover new mechanism that targets and destroys abnormal RNA
...ght interfere with some drug treatments for cystic fibrosis and other genetic diseases. The new studies sugges...ng of drugs called aminoglycosides to treat cystic fibrosis and other diseases caused by premature termination codons, said Dietz. The idea is that these drugs ...New method used to transfer genes into mouse
... procedure could help cure diseases such as cystic fibrosis or hemophilia." Largaespada is co-founder of Minneapolis-based Discovery Genomics, Inc., which has exclusive license to Sleeping Beauty and plans to commercialize this technology. http://www.discoverygenomics.net/...Novel gene therapy approach in 1st human trials
CLEVELAND, April 2, 2002: A 33-year old cystic fibrosis patient underwent the first gene therapy trial tod...lthy genes into the cells of the airways of cystic fibrosis patients, explains primary investigator Michael W. Konstan, MD, Director of the LeRoy Matthews Cyst...Study of vision disorder leads to discovery of new family of ion channels
...oride ion channel to be described since the cystic fibrosis transmembrane conductance regulator was discovered more than ten years ago. In addition to cystic fibrosis, mutations in chloride ion channels have been linked to several other human disorders, including diseases of the kidney and muscle. One of th...Scientists discuss microbial pathogenesis in era of bioterrorism, drug resistance
...s diseases, including those in the lungs of cystic fibrosis patients and on the skin of burn patients. Dr. Kaplans laboratory has been studying the twitching movement in which cells attach to neighboring cells to create the biofilm, and she believes such understanding of how the biofilm forms and functions w...CF Foundation seizes proteomics for drug discovery
...d, May 6, 2002The door to discovering novel cystic fibrosis (CF) drugs just swung wide open as the Cystic Fibr...y to find new types of molecular targets in cystic fibrosis (CF) cells, some that will point to new drug strategies. The proteomics research includes awards...New technique to make gene therapy more efficient
... already been many failed attempts to treat cystic fibrosis with gene therapy. Lungs are especially challengin...he build-up of thick sputum in the lungs of cystic fibrosis patients makes the problem even worse. But the replacement gene only needs to be expressed in a smal...New cell line increases research opportunities
...perm stem cells that cause diseases such as cystic fibrosis or hemophilia, transplant these corrected stem cells back into the testis, and all future offspring of that individual would be free from that particular disease."...Bacterial quorum-sensing structure solved
... of bacterial biofilm smothers the lungs of cystic fibrosis victims. Knowing the configuration of an essential quorum-sensing protein might permit structure-based design of a drug to block the chemical signal before bacteria join in a drug-resistant biofilm. Conversely, the rapid formation of useful biofilms,...Monkeys that drink heavily develop signs of liver disease, Wake Forest study shows
...re continuing to take biopsies regularly to see if fibrosis or liver inflammation develop. Cunningham said that one of his goals in the study was to develop diagnostic procedures that are similar to those used in the clinic for humans. "Can we follow the progression of this disease in monkeys by looking at b......ty to serious diseases such as haemophilia, cystic fibrosis and cancer. Teams at Cardiff University, Wales, and the University of Edinburgh, Scotland, who discovered a gene repair mechanism called the MBD4 enzyme in 1999, have now found that gene mutations are up to three times more common in mice lacking the...