Tag: "fibrosis" at biology news

Findings aid understanding of neurodegenerative diseases

...n's, Alzheimer's and Lou Gehrig's diseases, cystic fibrosis and Creutzfeldt-Jakob disease, the human form of mad cow disease. The findings, which will be published in the Oct. 1 issue of Nature Cell Biology, could lead to an understanding of how to prevent these diseases and to the development of effective d...

Cystic fibrosis gene mutations missing from some cases

...ins finds that some patients diagnosed with cystic fibrosis (CF) lack any of the more than 1,000 reported dise...FTR will improve diagnosis and treatment of cystic fibrosis and cystic fibrosis-like conditions." In the new study, of 74 patients diagnosed with non-classic CF...

World-first gene therapy for cystic fibrosis targets lung stem cells?

The genetically inherited disease cystic fibrosis causes severe, unrelenting lung disease in childre...erapy in our lungs. "Using a mouse model of cystic fibrosis Maria Limberis, a PhD student in our lab, has helped us develop a system to briefly overcome these d...

New screening technique may speed hunt for genes

...nvolved in a few inherited diseases such as cystic fibrosis have been identified, many have not. Now, two scientists say they may have found a way to make the search more economical and speed it up. In an article to appear online in the Proceedings of the National Academy of Sciences next week, scientists fr...

JCI Table of Contents, November 18, 2002

...n activator gene in mice reducesrenal interstitial fibrosis in obstructive nephropathy CONTACT: Youhua Liu University of Pittsburgh School of Medicine Department of Pathology S-405 Biomedical Science Tower 200 Lothrop Street Pittsburgh, PA 15261 USA Phone 1: 412-648-8253 Fax 1: 412-648-1916 E-mail: liuy@msx...

U.S.-German research consortium sequences genome of versatile soil microbe

...pathogen and the leading cause of death for cystic fibrosis patients. TIGR evolutionary biologist Jonathan Eisen said, "Such comparisons among closely related species with different biological properties are invaluable in learning about the biology of each species. In this case it allows us to better identify...

JCI Table of Contents, December 2, 2002

... of waterfrom the circulation. In 1989 the cystic fibrosis gene was identified and found to encode achloride channel in cells lining the lung. Recognized as the cystic fibrosistransmembrane conductance regulator (CFTR), no compounds were known toinhibit the activity of this channel - until now. In the Decemb...

Alternative treatment for secretory diarrhea linked to the cystic fibrosis gene

...f water from the circulation. In 1989 the cystic fibrosis gene was identified and found to encode a chloride...in cells lining the lung. Recognized as the cystic fibrosis transmembrane conductance regulator (CFTR), no compounds were known to inhibit the activity of this ...

A new approach holds promise for reducing cocaine craving

... n-acetyl cysteine, which is used to treat cystic fibrosis and several other disorders reverses the changes in brain chemistry that appear to cause cocaine craving," said David A. Baker, a post-doctoral fellow in the laboratory of Peter W. Kalivas at the Medical University of South Carolina. Baker presented...

Observing proteins and cells in the wild

...ical ones. For example, in such diseases as cystic fibrosis and Alzheimer's, certain proteins travel to the wrong places; like a milk truck delivering its goods to a post office instead of the grocery store, the aberrant proteins disrupt the working community of the cell. By using quantum dots to follow these...

Purdue works to transform Ebola virus from killer to healer

... certain defective genes within lung cells. Cystic fibrosis and lung cancer are diseases that Sanders' group hopes to tackle. "Cystic fibrosis is the most common serious genetic disease among Caucasians in the world," Sanders said. "Lung cance...

JCI table of contents, December 15, 2002

... ACCOMPANYING COMMENTARY:Unexpected news in renal fibrosis CONTACT: Juan A. Oliver Columbia University Department of Medicine 630 West 168 Street New York, NY 10032 USA Phone: 212-305-6938 Fax: 212-305-3475 E-mail: jao7@columbia.edu View the PDF of this commentary at: https://www.the-jci.org/press/17399....

Applied Biosystems announces SNPlex ultra high throughput genotyping system

... is also employed in the Celera Diagnostics cystic fibrosis test, which has become one of the leading tests for detection of mutations associated with this disease. The SNPlex TM system will operate on the same instrument platform widely used for sequencing and linkage mapping, and can be used with both cus...

New drug lead fights bacteria that can be lethal by disrupting quorum sensing and biofilms

...ection that strikes -- and usually kills -- cystic fibrosis patients and many others whose immune systems are ...une systems are compromised. In addition to cystic fibrosis patients, whose lungs become clogged with the bacteria, it infects patients receiving chemotherapy, ...

Univ of MD study on prevalence of celiac disease

... as Crohn's disease, ulcerative colitis and cystic fibrosis combined," says Alessio Fasano, M.D., the study's principal investigator and professor of pediatrics, medicine and physiology at the University of Maryland School of Medicine. Celiac disease is a digestive disorder that is triggered by the protein ...

UI study discovers cells segregate molecules to control signaling

...y. Certain airway diseases such as asthma, cystic fibrosis and smoking-associated bronchitis are known to impair the airway barrier. The UI study suggests that under these disease conditions heregulin or other messenger molecules might not be well segregated from their receptors, and the receptors might be a...

New proteomic techniques reveal workings of bacteria linked to cystic fibrosis

...aeruginosa establish itself in the lungs of cystic fibrosis patients. The researchers used a new technology to...nosa is so virulent that it will often kill cystic fibrosis patients. The highly sensitive quantitative proteomic analysis of a whole bacteria performed in this...

Cystic fibrosis gene therapy trial results encouraging

...st-of-its-kind gene therapy trial involving cystic fibrosis (CF) patients and a new compacted DNA technology. The Phase I trial involving 12 patients was launched one year ago by University Hospitals of Cleveland (UHC), Case Western Reserve University (CWRU) School of Medicine, Children's Hospital of Denver, ...

Borrowing from Ebola virus could aid cystic fibrosis gene therapy

...roblem with current efforts in developing a cystic fibrosis gene therapy is that delivering genes into airway ...The discovery has implications for treating cystic fibrosis and other lung conditions where the genes needed for healthy lung function are mutated or absent. "M...

Scientists investigate several techniques to achieve successful gene therapy

...eveloped, the cancer, vascular diseases and cystic fibrosis markets are likely to be the first to reap financial benefits from gene therapy. "Once the first successful products are on the market, numerous others are sure to follow and investor enthusiasm will most likely equal that currently enjoyed by monocl...

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