Tag: "fibrosis" at biology news

Putting genes in a pill

...promise of curing diseases such as diabetes,cystic fibrosis or Parkinson's disease by replacing damaged ormissing genes. To do that, a new piece of DNA has to be carried intocells in the right part of the body. Most approaches have used some kind of genetically modified virus tocarry the DNA into the cell. Bu...

National Jewish faculty to present research at American Thoracic Society

... May 21, 8:15 a.m. PDT Most people think of cystic fibrosis as a young person's disease, with patients dying b...t when he describes a growing population of cystic fibrosis patients over the age of 40. The growth in the adult cystic fibrosis population comes from two main ...

Heart drug might help fight chronic fungal infections

...ssed immune systems or with conditions like cystic fibrosis that increase susceptibility to chronic or recurring fungal infections, prolonged use of azoles can lead to the fungus becoming resistant to treatment. Finding a way to treat severe and life-threatening fungal infections with an option that boosts th...

Tips from the Journals of the American Society for Microbiology

...scarring, or fibrosis, of the lungs. In time, this fibrosis can build up to the point where the lungs are unable to provide oxygen to the tissues of the body. In studies of patients with IPF, the average survival rate has been found to be 4 to 6 years after diagnosis. The cause of IPF is currently unknown. I...

Artificial organ research findings presented by University of Pittsburgh researchers

...ase, diabetes, Parkinson's disease, stroke, cystic fibrosis and muscular dystrophy." Established by the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center, the McGowan Institute of Regenerative Medicine has a broad mission to develop a premier facility for clinical car...

U-Iowa physician suggests possible enzyme deficiency in cystic fibrosis

...y accumulates in the lungs of patients with cystic fibrosis (CF) may be linked to the deficiency of an enzyme ...n genetic mutation in CF -- a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The possible connection is proposed by Joanne Tobac...

JCI table of contents, July 1 2003

...https://www.the-jci.org/press/19069.pdf Cystic fibrosis study reveals second chloride transport abnormality Cystic fibrosis (CF) is characterized in part by the inadequate absorption of nutrients from the small intestine. A ...

Genome researcher analyze chromosome 7

...onal cloning in the successful hunt for the cystic fibrosis gene. "Chromosome 7 has long been of interest to ...nt, this chromosome also holds the gene for cystic fibrosis and is frequently damaged in some types of leukemia and other cancers," said Francis S. Collins, M.D...

JCI table of contents, July 15, 2003

...tps://www.the-jci.org/press/16814.pdf Fighting fibrosis in liver disease Liver injury and fibrosis are cardinal features of most chronic human liver diseases and they result from inflammation and the...

JCI Table of Contents, 15 August 2003

...7.pdf Integrin-linked kinase mediates kidney fibrosis Emerging evidence suggests that during certain d..., that may ultimately result in renal interstitial fibrosis and renal failure. EMT is regulated by numerous hormones and growth factors, including tumor growth ...

Leading bacterial pathogen is sequenced

...terium that causes fatal lung infections in cystic fibrosis patients. And environmentalists could be provided ...ed for chronic and fatal lung infections in cystic fibrosis patients and acute infections of cancer and burn patients, says Collmer, who is principal investigat...

Drug developed for rare disease may help millions more as treatment for cancer, autoimmune diseases

...st copper, which serves to choke off tumor growth, fibrosis and inflammation. U-M researcher George Brewer, M....also looking into the effect of TM on inflammatory fibrosis diseases such as pulmonary fibrosis, cirrhosis, cystic fibrosis and psoriasis. "TM has the potential...

Discovery may be first plant cell surface molecule that halts cell proliferation

...ncluding some involved in diseases, such as cystic fibrosis and cancer. "We have identified the first and a truly novel regulator of G protein signaling, or RGS signaling protein, in Arabidopsis," said Dr. Jin-Gui Chen, senior research associate in the department of biology and the report's first author. "Thi...

A test for sensitivity of normal tissue to radiation damage?

...els of two types of radiation damage: subcutaneous fibrosis (scarring under the skin) and telangiectasia (an increase in small blood vessels under the skin). The XRCC1 and XRCC3 genes code for proteins involved in the repair of radiation-induced DNA damage; SOD2 is the gene for the protein that eliminates to...

JCI Table of Contents, November 3, 2003

...**** Revealed: a role for angiotensin II in liver fibrosis NADPH oxidase mediates the effects of angiotensin II, which causes fibrosis following liver injury. David Brenner and colleagues from the University of North Carolina report th...

Genetic aberration helps explain variation in cystic fibrosis

... mutations in a gene called CFTR, short for cystic fibrosis transmembrane conductance regulator. When specific mutations appear in both copies of the gene, a sticky mucus builds up in the lungs, making breathing difficult and trapping bacteria that can cause serious and deadly infections. One CFTR mutation...

Biofilm antibiotic resistance may be susceptible to genetic approach

...mycin, commonly used to treat patients with cystic fibrosis (CF), a disease where biofilms are thought to develop in patients' lungs. "This is a proof of concept that there may be a possibility of identifying small molecules to attack biofilm resistance, thereby rendering these microbial communities more sus...

Calcium channels control coronary artery relaxation

...ous tissue in heart muscle. "We believed that this fibrosis was probably not due directly to the cardiac muscle abnormality, because we knew that a T-channel was not present in adult ventricular muscle," said Campbell. "So, it must have been caused by another abnormality, maybe in the blood vessels." When the...

JCI Table of Contents, January 15 2004

... Bone marrowderived stem cells active in pulmonary fibrosis Adult stem cells have long been thought to be res...eposition in the lung causing idiopathic pulmonary fibrosis may develop from cells derived from bone marrow stems cells, rather than parenchymal lung fibroblast...

UI researchers discover new activity in cystic fibrosis protein

...ve discovered a new enzyme activity for the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is the protein that is defective in cystic fibrosis, a common life-threatening genetic disease that affects primarily the lungs and pancreas of young people. The discovery, which appeared in the Dec. 2...

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