Trojan Horse Virus Controls Hiv Infection
...to-cell HIV infection to occur. HIV-infectedcells flag themselves for destruction by the body'simmune system by displaying HIV's outer coat protein. But this protein, HIVgp120, is the same one that attaches to the T-cell receptors and leads toinfection. Cell-to-cell infection occurs when the HIV gp120 ...Microchip Sensor Detects Bacteria
...laughterhouse to the restaurant, and send up a red flag when there's a problem. The biosensors, developed by Harold Craighead, professor of applied and engineering physics, in collaboration with Carl Batt, professor of food science, are simple in concept and arose from technology that is the mains......e presence within the donor organmight raise a red flag that could signal a targeted host immune response. In organ transplantation, Dr. Starzl's team has long believed,immunosuppressive drugs, at least initially, are necessary to oversee thisprocess. The drugs control the two-way traffic of cell...Experiments illuminate workings of biological clocks
...ess for destruction byproteasomes. Normally, cells flag proteins for destruction and recycling bytagging them with a small protein known as ubiquitin. Using their fly cell culture system, the scientists confirmed that TIM isindeed "ubiquitinated," demonstrating that it is a target of the proteasome.Fina......ogens, wounds and other insults. The sensors would flag the onset of a problem before any visible signs appeared. "These sensing systems will all be molecule size with their own telemetry," says Troy Nagle, a sensor expert at North Carolina State University who is also a group member. The sensors might s...Immune system helps prevent tumors after all
...g." The researchers examined one potential way to flag tumors for easier identification by the immune system. They added a protein called TAP1. This molecule appears to be absent from some tumors that escape immune detection. When highly aggressive tumors such as those that managed to develop in mice wit...Novel means for stopping transcription found, Hopkins scientists report
...opkins School of Medicine. "Nrd1 doesn't just flag a new stop sign, it actively takes part in controlling gene expression -- the process of interpreting genetic information to make proteins," says Corden, a professor in the department of molecular biology and genetics, part of the school's Institute ...Chemgenex reports use of chemical genomics strategies to advance drug development
...rovide insight into effective dosing regimens, and flag potential toxicities prior to clinical testing. Assessing Mechanisms of Action for Lead Drug and Analogs In one poster presentation titled, Identification of Molecular Targets for an Anti-Cancer Agent Quinamed(TM) Using High Density Expression Arra...U. Va. scientists find new piece of gene expression puzzle
...ividually," Allis said. "If the ubiquitin chemical flag seems to govern methylation of lysine at K4, but not elsewhere, there is a selectivity going on, and it's remarkably more complicated than we thought. When we reported on the methylation of lysine at K4 and K9 last summer, we had no clue it was being...Ulcer-causing bacteria use stomach inflammation to their advantage
...ar, known as sialyl-di-Lewis x (sLex), serves as a flag to attract immune cells to the infection site. The worse the inflammation, the more sLex the cells display. The investigators also discovered, however, that H. pylori latches on to the new sugar using a previously unknown bacterial adhesin protein, e...Is the American public at increased risk for food poisoning?
...But the public would be surprised to find a yellow flag hoisted for a wide range of foods and food components. They include whole wheat flour, potassium chloride, thiamine, vitamin A (too little), raw eggplant, raw egg whites, iron supplements, caffeine (iron), magnesium (renal), and raw cabbage (iodine)...New drug that enhances glutamate transmission in the brain being evaluated for fragile X
... patient with fragile X syndrome, that's a big red flag because that means the mutation has been in the family in a silent form for years," says Berry-Kravis. Males are typically more severely affected than females. Although most males have mental retardation, only one-half of females have intellectual i...A red flag for lethal prostate cancer
...r high levels of this protein could serve as a red flag for physicians and help save the lives of men with the most dangerous form of the disease. "We found the greatest EZH2 overexpression in metastatic prostate cancer tissue. At this point, it's unclear whether the gene plays a role in cancer's developm...Food pathogen vector shows promise against cancer
...macrophage and serves as an antigen, a sort of red flag that tells T-cells what to search for and eliminate within the body, in this case melanoma cells coded with ovalbumin. "We are now moving toward insertion of numerous pathogen-specific antigens into the vector to elicit protective responses," says Hi...Discovery of size changes of Bacillus spores may lead to simpler, faster anthrax detector
... anthrax spores,'" added Price, "but it would be a flag for you to go to the next step, perhaps a PCR test to detect anthrax DNA." The new technique also could mark a significant advance in biological imaging. "The technology that Price and Westphal have developed is quite extraordinary," said Leighton, a......ide by side, scientists can quickly spot genes and flag interesting regions for further investigation. Analyzing the organization of the two genomes, Stein et al. not only found strong evidence for roughly 1,300 new C. elegans genes, but also indications that certain regions could be "footprints of unknow...Transplant rejection averted by simple light exposure in Stanford animal study
... Langerhans cell. These cells normally function as flag posts for the immune system, signaling infection-fighting T-cells to come to a particular site to fight off a virus or bacteria. But in transplants, they do patients a great disservice, alerting T-cells to attack the patient's own tissues, researcher...Mite transmits viruses damaging to wheat
...op circle was dying down rapidly, and that's a red flag the mite has been spreading the viruses in early planted irrigated fields." In addition, several client farmers were just plowing up damaged fields of 200 to 700 acres. "With fuel costs what they are right now, trying to salvage severely damaged...Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
...two punch to cancer cells. Antigens are like a red flag to a bull -- they draw an attack from cells of the...strength of the immune response depends on how the flag is waved. "This immune therapy uses bacteria that induce both inflammation and an immune response to...