How an insidious mutation fools DNA replication
DURHAM, N.C. -- Biochemists have pinpointed how a flaw in DNA that is central to mutations in cancer and aging fools the cellular enzyme that copies DNA. Their finding explains how oxidative DNA damage -- a process long believed to underlie cancers and aging -- can create permanent genetic damage. The Du...Mutated protein combination tied to excessive sugar production
...aking process. Furthermore, when mutations cause a flaw in one of the proteins, the switch no longer can respond to insulin, the hormone that normally regulates sugar manufacture in the liver. The actual molecular connections between the proteins are potential targets for diabetic therapy, says Spiegelman...Researchers discover important genetic flaw in family affected by schizophrenia
...he University of Alberta have discovered a genetic flaw in a family suffering with schizophrenia that may help to explain an important biochemical process implicated in the onset of the disease. Studying a British mother and daughter, the researchers discovered that both were found to have a "break" in a...Australian overturns 15 years of nano-science doctrine
...ic practice out the window by discovering a design flaw in a key component of the Atomic Force Microscope. His finding will force a rethink into the design and use of an instrument that has become a cornerstone of scientific measurement and analysis. Dr John Sader, at University of Melbourne's Department...A new window to view how experiences rewire the brain
...e synaptic densities," said Svoboda. "However, the flaw in this view has been that a stable density only indicates a balanced rate of birth and death of synapses. It doesn't imply the absence of the formation of new synapses, but it was often interpreted that way." In their experiments, Svoboda and his co...Misfolding the key to protein's ability to kill brain cells
...n humans may be hereditary and linked to a genetic flaw or occur sporadically at the rate of about one case per million people. But the disease can also be contagious and spread like an infection. At least 93 people died after exposure to BSE ...Targeting enzymes that immortalize cancer cells: if you can't turn them off, round them up
...and over, are there to protect valuable DNA from a flaw in the DNA replication process. The machinery that reads and duplicates DNA can't go all the way to the end of the chromosome, so a few base pairs - the building blocks of DNA - are lost from the ends each round. During a single cell division, human ...Monogamy appears to be unnatural in the natural world
...r spouse does not love you, that it is a character flaw or that they never cared for you. There are a lot of reasons for adultery and it takes a hell of a lot of diligence to stay monogamous." Barash said numerous recent studies have shown that many animals and birds, such as eagles, geese, beavers and......give up on it." Caldeira thought he saw a central flaw in all of these Sun-dimming ideas. While reducing sunlight might have an overall cooling effect on the planet as a whole, he argued, it wouldn't counteract the local heating effect from CO2. The two forces act in a completely different way on differe...Researchers develop new technique for identifying remaining unknown human genes
.... "We have identified and corrected a fundamental flaw in the current genomewide gene studies," note the authors in the April 11 issue of the Proceedings of the National Academy of Sciences. The technique they developed "provides a much higher degree of novel gene identification than the current approac...ANN ARBOR, Mich. - Just like the smallest flaw in Achilles' strength led to hisdownfall, the smallest proteins produced by cancer cells may someday givedoctors new ways to find tumors earlier than ever, determine quickly howmalignant they are and target them with customized therapies. Now, a five...Jefferson Researchers Use Gene Therapy To Treat Rare, Inherited Brain Disease
...s an insulator. The disease is caused by a genetic flaw in which an enzyme fails to be produced. The disease is incurable, resulting in the over-production of a toxic compound in the brain, N-acetyl-aspartate (NAA). Death usually occurs between the ages of 5 and 7. Symptoms of Canavan disease, which appea...Bacterial Protein Structure Hints At Mechanism Of A Class Of Premature Aging Diseases
... The events taking place between the genetic flaw and its expressionas a disease are unknown. "It's not enough to know where a defectin the gene is." Bastia said. "You want to know how it causesthe disease." If the mechanism of a genetic malfunction can be mapped out, said Bastia,drug therapi...