St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules
... idea by showing how a protein called p27 uses two flexible arms to help it bind to a protein complex called C...n part of each type of cyclin is unique. The first flexible arm of p27 recognizes only certain types of cyclin, based on that unique part of the molecule. The f...Purdue chemists 'put the twist' on protein building block
...eeded to twist tryptamine, a molecule with several flexible "hinges" that bears a close resemblance to an amino acid, the basis of proteins. Understanding the energy pathways that these molecules take passing from one conformation to another could provide new understanding of the elusive process of protein fo...Insights gained from molecular modeling may lead to better insecticides
...s are missing, creating a much more accessible and flexible catalytic site. As a result, toxins of many different shapes and sizes can enter and be detoxified. Since the toxins are not as rigidly restricted, they are not detoxified quite as efficiently as some of the toxins encountered by the speci......day when Shih was building a number of shapes with flexible ball and stick models in the laboratory. This exercise attracted his attention to an important structural principle: frames built with triangular faces are rigid, while cubes and other frames built with non-triangular faces are easily deformed. Tra...Purdue engineers develop quick, inexpensive method to prototype microchips
...uch as those found in glass wall insulation, and a flexible polymer called PDMS that is available from most scientific supply companies. "What we've done is really thinking outside of the box," said Nate Mosier, an assistant professor of agricultural and biological engineering who also contributed to this p...Ultra-thin coating traps DNA on a leash
...esearch Institute. "The DNA that attaches to this flexible leash is able to act as if it were free floating." The organic molecules that make up the coating have one end that attaches to the glass and the other end with three functional amine groups where DNA strands can interact and attach. Retention of D...... sea life with a primitive spinal cord and a firm, flexible outer covering called a "tunic," from which the name derives. These siphon-feeding animals form dense mats, made of many thousands of individuals, encrusting and smothering hard sea bottom and organisms attached to it. According to researchers, the G...Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
...l shape of the protein, a form achieved by folding flexible chains of amino acids until each is properly aligned so that the protein can do its job. Normally, the folding of proteins is highly efficient and specific, but sometimes the process goes awry, resulting in dangerous misfolded forms. Prion diseases ...UT Southwestern scientist awarded prestigious American Cancer Society research professorship
...ctive Jan. 1, 2004. The ACS Professorships provide flexible funding for established full-time investigators in mid-career who have made novel or watershed contributions to cancer research and are expected to continue to provide leadership in their research areas. The American Cancer Society grants no more tha...UVa scientists detail salmonella protein
...tedly compact, heart shaped, with a globular core, flexible polypeptide extensions and a large patch that may help SipA bind to the mostly acidic surface of actin....Lens replacement material may improve cataract treatment, eliminate bifocals
...remove the old lens material and replace it with a flexible plastic lens. The new strategy would be to careful...eplace the extracted lens material with the clear, flexible polymer that Ravi's lab has developed by carefully injecting it into the empty capsular bag. Such ...Laboratory 'theme park' re-creates RNA world for study
...news. The good news was that these RNA enzymes are flexible and robust enough to bind to just about any kind of template regardless of its sequence findings that eluded earlier experiments. The more sobering news was that these new sequences of RNA are at most 14 nucleotides long, which, while still a major ...Jaws of clamworm are hardened by zinc say UCSB scientists
...nformation on how scientists can make lightweight, flexible materials ranging from more durable tires to protective coatings. The scientists found that that this polychaete worm (a marine worm with bristle-tipped organs of locomotion) has the greatest amount of zinc concentrated toward the tip of its jaw, whe...Researchers identify protein modules that 'read' distinct gene 'silencing codes'
...tween two similar locations on the histone tail, a flexible protein chain that pokes through the tightly folded chromatin complex. Each chromodomain therefore docks to a specific location, but not another. The research reported in the Genes & Development paper focuses on a chemical reaction called methylatio......gist Scott McWilliams have shown that birds have a flexible digestive system that they modify to meet the changing energy demands of migration. "The gut of a migratory bird is a really dynamic organ. In preparation for migration, the gut increases in size tremendously over several days," McWilliams said. "......cifically recognizes a highly restricted number of flexible surface loops next to the negatively charged amino acid residue called aspartate (Asp) found in a group of intracellular cysteine proteases known as caspases (cysteine protease with aspartate specificity) and activates this proteolytic starter (to be...Artificial organ research findings presented by University of Pittsburgh researchers
...in Dr. Wagner's laboratory have developed a novel, flexible and biodegradable material based on a specialized polymer that is porous to encourage the infiltration and growth of cells. This "cardiac patch" was tested in the repair of defects in adult rats. After four weeks, the patches and nearby tissue were s......rk. "The discovery allows researchers to tailor flexible materials to a given application--to get the tough materials that nature has been able to produce," said Lynn Schneemeyer, the NSF program officer who oversees Kotov's award. NSF is an independent federal agency that supports fundamental research an...Johns Hopkins researchers devise methods to evaluate disaster drills
...to a disaster. We created a set of tools that are flexible enough to be practical for disaster planners worldwide." The methods, published in the May issue of the Annals of Emergency Medicine, break evaluation of drills into four parts: command and control (including the time from initial notification of a ...Research and development takes robots and automation into new territory
...udio capabilities, these machines have become more flexible and skillful. "Researchers and technologists are increasingly striving toward developing innovative techniques that include the use of artificial intelligence and progress to less human supervision," states Technical Insights Analyst Anand Subramania...