Disruption of protein-folding causes neurodegeneration, mental retardation
...molecule called GM1-ganglioside (GM1) disrupts the folding of newly assembled proteins into their proper shap...ein production and increase efforts to correct the folding of misfolded proteins. Over time, however, this emergency response may fail to cope with the stress,...Images reveal how rotavirus - leading cause of diarrhea - enters cells
...els." Dormitzer and colleagues speculate that this folding motion causes the spike's "body" component to break a hole in the cell membrane, allowing the virus to enter. The key finding for vaccine development is that the "head" and "body" portions of the VP4 protein contain many of the targets that the immun...New clues to hereditary blinding disease found
...present and plays a significant role in the normal folding and functions of rhodopsin, and if defective, leads to retinal degeneration. "We have found if there is not enough zinc in the body or there is a mutation in the zinc binding site, the protein rhodopsin will misfold and break down, triggering cell de...Scientists visualise cellular handmaiden that restores shape to proteins
...about how the important molecule may do its job of folding new or damaged proteins within cells. Led by Profe...t of shape protein in to the cage for some protein folding therapy. The folding changes in the cavity are driven by the cell's energy source, ATP. It takes ju...Story tips from the Department of Energy's Oak Ridge National Laboratory, August 2004
...n many biological reactions. These include protein folding and intracellular protein transport. Cyclophilin A is also required for the infectious activity of HIV-1. Funding is provided by DOE's Office of Science, Office of Biological and Environmental Research. [Contact: Ron Walli, 865-576-0226; wallira@or...Scientists receive awards, give lectures at the ASBMB/IUBMB meeting
...y has developed new methods for characterizing the folding determinants and folding behavior especially of larger proteins and has used them to characterize the folding of yeast triose...Researchers discover protein that dissolves amyloid fibers
... implications for our understanding of the protein folding process in amyloid-related conditions." This research also may contribute to scientists' understanding of evolution. Prions, those infectious proteins implicated in conditions such as mad cow disease, are a subclass of amyloids. In yeast cells, Sup35...Controlling biomolecules with magnetic 'tweezers'
...ds of DNA. The device should help scientists study folding patterns and other biochemical details important in medical, forensic and other research areas. The new NIST device works like drawing toys that use a magnetized stylus to pick up and drag magnetic particles. Magnetic particles 2 to 3 micrometers acr......chaperones," cellular proteins that aid in protein folding and transport, resulting in smaller prion particles called propagons. The propagons are then distributed to both mother and daughter cells during division, thereby infecting the next generation of cells. Lev Osherovich and colleagues confirmed what ...St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules
...dk2-cyclin A, one of its arms binds to cyclin A by folding into a rigid shape. After the first arm binds, the center rod settles across the entire Cdk2-cyclin A complex. Finally, the second arm also folds into a rigid shape onto the Cdk2 part of the complex. In this way, proteins such as p27 act as molecula...Experiments establish 'protein-only' nature of prion infections
...ctive shapes. "The use of temperature to influence folding was an elegant approach, because once you've chang...as distinct strains -- providing templates for the folding of other proteins into the same shapes. Further structural analyses of two of the strains confirmed ...Biochemistry and Molecular Biology: Research at the Interface of Biochemistry and Human Health
...NY at Stony Brook, with symposia on topics such as folding in the ER and degradation of proteins. Protein Structures, Catalysis and Dynamics, organized by Susan Taylor, University of California at San Diego, with symposia on topics such as site-directed drug discovery and tethering and targeting of prote...Purdue chemists 'put the twist' on protein building block
...emory. Using lasers to initiate and probe the folding process, a group including chemist Timothy Zwier h...ew understanding of the elusive process of protein folding - an essential part of the development of these fundamental biological molecules. And though tryptam...Computer method identifies potentially active enzymes
...ause these clashes that prevent these hybrids from folding correctly," says Saraf. "We hypothesize that the greater the number of clashes that exist in the hybrids, the less likely it is to fold correctly and therefore lower activity will be present." The hybrid combinations are then ranked for predicted e...'Kissing' RNA and HIV-1: Unraveling the details
...k during viral infection. To track RNA binding and folding in real-time, the CARB scientists developed fluorescent markers as substitutes for pieces of the RNA. By monitoring changes in the fluorescent signal, the scientists could follow these reactions. The scientists also used nuclear magnetic resonance to...New research technique provides clues into cell growth
...WASP, this is the first study in which the natural folding and unfolding of a single protein was observed. Al...whether similar probes can help us visualize other folding proteins."...Yeast helps researchers better understand Parkinson's mystery
...cells needed genes that were involved with protein folding and quality control. For aSyn, genes involved with lipid metabolism and membrane trafficking kept the cells alive. "A lot of people had hoped that these two diseases would have common mechanisms and that one drug might cure both of them," says Much...Fox Chase Cancer Center researcher develops new model for studying prions mad cow disease
...mensional shape of the protein, a form achieved by folding flexible chains of amino acids until each is prope...so that the protein can do its job. Normally, the folding of proteins is highly efficient and specific, but sometimes the process goes awry, resulting in dang...Researchers design and build first artificial protein
... and predicting the rules that govern this complex folding process -- involving the folding of the main backbone and the packing of the molecular side chains of the amino acids -- is one of th...Beyond biology: Simple system yields custom-designed proteins
...t been much emphasized in either the design or the folding fields." Previously, the only ways for scientists to invent new proteins have been to churn out random sequences and screen them for well-folded proteins or to calculate, atom-by-atom, combinations that will fold into a desired shape. The first is di...