Finding a 'Holy Grail': simulated and experimental protein folding compares nicely
...e comparison of simulated and experimental protein folding kinetics has been a "Holy Grail" for biologists an...irectly compare simulated and experimental protein folding dynamics, such as folding rates and equilibrium constants," said Martin Gruebele, an Illinois profes...Researchers find mechanism responsible for neuronal death in prion diseases
...an coax other prion proteins into this alternative folding pattern and cause them to clump together. Lindquis..., it has evolved as a way to kill neurons with PrP folding problems, thereby reducing the risk that PrP will accumulate at sufficient levels to produce the inf......o not express CAD (ICAD is required for the normal folding of the CAD protein, and therefore its activity) and so no apoptotic DNA fragmentation occurred. The DNase II-deficient flies were able to fragment DNA inside the dying cells, but the fragmented DNA accumulated and activated an innate immune response....Kurt Wthrich of The Scripps Research Institute wins 2002 Nobel Prize in Chemistry
...--the very large protein complex that monitors the folding of newly synthesized proteins. He also has been looking at ways of solving membrane protein structures, which are some of the least solved of all the relevant molecular structures in biology. Less than one half of one percent of the structures contai...Revealed: How a master protein remodels chromosomes to orchestrate gene expression
...onths of a meter across. Many orders of chromatin folding are necessary to fit the genome into a small nucleus, and this complicates the process of gene expression. For a gene to be transcribed, the double-stranded DNA that encodes it has to be unzipped -- hard to do inside tightly wound chromatin. So gene ...Findings aid understanding of neurodegenerative diseases
...In this delicate process, the protein receives its folding instructions from its amino acid sequence and is assisted by a class of proteins known as heat shock proteins or molecular chaperones that function to prevent misfolding, or, in the case of already misfolded proteins, to detect them and prevent their...UC Riverside to play active role in Institute for Complex Adaptive Matter
...anizing principles that may be responsible for the folding of proteins and their association with illnesses such as Alzheimer's; the measurement and understanding of emergent behavior in high temperature superconductors; the emerging field of biological physics; and the development of measuring systems on th...UC & sister institutions form 'Institute Without Walls' for transdisciplinary collaborations
...anizing principles that may be responsible for the folding of proteins and their association with illnesses such as Alzheimer's and "Mad Cow" disease, the measurement and understanding of emergent behavior in high temperature superconductors, designing self-assembling materials, the emerging field of biologi...Protein simulation can be done three times as fast
...le. Biologically interesting processes such as the folding of proteins, occur in a matter of milliseconds. For this the fastest Pentium has to calculate day and night for 200 years. Supercomputers can perform these calculations about 100 times faster. Researchers expect that supercomputers will be so fast in......hese investigators have managed to circumvent this folding difficulty. They have been able to efficiently inhibit the activities of a number of target RNAs, even at sites that are known to be inaccessible to regular ribozymes. This has further allowed them to develop a method for investigating the functions ...Scientists find protein at the intersection of genetics, development, and environment
...hysical characteristics." "The process of protein folding interacts with our biology and our environment in so many ways. We've just begun to grasp it. Its like holding a tiger by the tail," Lindquist said....CF Foundation seizes proteomics for drug discovery
... during all of its functions, including synthesis, folding and transportation to the cell membrane. Scientists will compare such protein interactions in mutant [disease-associated] versus normal CFTR, said Melissa Ashlock, M.D., director of drug discovery at the CF Foundation. The ultimate goal is to identi...Researchers narrow search for structure of cholera toxins extracellular transport signal
...ino-acid-region," Folster said. "In the process of folding during protein maturation, these two regions are brought together to form an active extracellular transport signal. If we can precisely locate that small portion of the protein where the signal is actually formed, we can target it for intervention."...Scientists conduct first DNA field tests on Antarctic soil microbes
... more spacious laboratory structure, with a table, folding chairs, a heater, and a coffee machine a little luxury in the Dry Valleys!...Physics tip sheet #3 March 6, 2002
...h a video camera and simple image recognition, the folding and unfolding of the molecule and other molecular processes can be simulated and analyzed. The results are applicable to many areas of polymer and statistical physics. Journal article: http://link.aps.org/abstract/PRE/v65/e031306 3) Turning the su...The path to a folded protein, long a subject of debate, appears in many cases to be long and winding
...ebate in the world of physical chemistry: Does the folding of proteins into biologically active shapes better... support for a more heterogeneous model of protein folding comes in a paper published today on the Web site of the Proceedings of the National Academy of Scien...Folding upon binding: unique protein activation mechanism found by scientists at TSRI
...s biologists with a first glimpse of a synergistic folding mechanismwhich may be a commonplace occurrence in the cell. The two proteins are a nuclear receptor coactivator and the general transcription coactivator called CBP, and their structure is reported in the current issue of the journal Nature by a grou...Energy landscape paving: A better way to find a better way
... that they use it to address the notorious protein folding problem, which has baffled scientists for decades....proteins are formed, they almost immediately begin folding into incredibly complex structures that interact with other proteins, often in lock-and-key type arr...In harshest environments, some proteins protected by 'alternate' folding mode
...gy state by the action of the pro-region. When the folding is complete, the pro-region is degraded, and the a...ctional form. "This novel way of achieving protein folding is apparently nature's ultimate strategy to protect proteins from being digested by proteases," said...Prizes awarded in the 2002 Gottfried Wilhelm Leibniz Programme
...gained pioneering insights in the field of protein folding when he had finished his doctorate. He was able to demonstrate that successful folding of proteins does not occur spontaneously, as had hitherto been assumed, but that it depends on the p...